The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Applications of Nanobiotechnology in Clinical Diagnostics
Abstract
Background: Nanobiotechnologies are being applied to molecular diagnostics and several technologies are in development. Methods: This review describes nanobiotechnologies that are already incorporated in molecular diagnostics or have potential applications in clinical diagnosis. Selected promising technologies from published literature as well as some technologies that are in commercial development but have not been reported are included. Results: Nanotechnologies enable diagnosis at the single-cell and molecule levels, and some can be incorporated in current molecular diagnostic methods, such as biochips. Nanoparticles, such as gold nanoparticles and quantum dots, are the most widely used, but various other nanotechnological devices for manipulation at the nanoscale as well as nanobiosensors are also promising for potential clinical applications. Conclusions: Nanotechnologies will extend the limits of current molecular diagnostics and enable point-of-care diagnostics, integration of diagnostics with therapeutics, and development of personalized medicine. Although the potential diagnostic applications are unlimited, the most important current applications are foreseen in the areas of biomarker discovery, cancer diagnosis, and detection of infectious microorganisms. Safety studies are needed for in vivo use. Because of its close interrelationships with other technologies, nanobiotechnology in clinical diagnosis will play an important role in the development of nanomedicine in the future.
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Self-citation
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Noble Metal Nanoparticles for Biosensing Applications
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Nanomaterials for Neural Interfaces
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Nano/Microfluidics for diagnosis of infectious diseases in developing countries
Lee, W. G., Kim, Y.-G., Chung, B. G., Demirci, U., & Khademhosseini, A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.016 · Cited by 357
Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures
Barry, R. C., Lin, Y., Wang, J., Liu, G., & Timchalk, C. A. (2009) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2008.71 · Cited by 73
Metadata
- Authors
- Jain, K. K.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-01
- Volume
- 53
- Issue
- 11
- Pages
- 2002-2009
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2047738367
- Cited by
- 381
- References
- 22
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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