Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide
Abstract
Introduction C-peptide measurement in blood or 24-h urine samples provides useful information regarding endogenous insulin secretion, but problems related to the rapid degradation of C-peptide in blood and difficulty of 24-h urine collection have limited widespread routine clinical use of this test. We assessed the feasibility of measuring urinary C-peptide (UCP) with correction for creatinine concentration in single urine samples. Methods We analyzed UCP using a routine electrochemiluminescence immunoassay in samples from 21 healthy volunteers. We investigated the stability of UCP with different preservatives and storage conditions and compared the reproducibility of urinary C-peptide/creatinine ratio (UCPCR) in first- and second-void fasting urines, then assessed correlations with 24-h collections. Results UCPCR was unchanged at room temperature for 24 h and at 4 degrees C for 72 h even in the absence of preservative. UCPCR collected in boric acid was stable at room temperature for 72 h. UCPCR remained stable after 7 freeze-thaw cycles but decreased with freezer storage time and dropped to 82%-84% of baseline by 90 days at -20 degrees C. Second-void fasting UCPCRs were lower than first-void (median 0.78 vs 1.31, P = 0.0003) and showed less variation (CV 33% vs 52%), as second-void UCPCRs were not influenced by evening food-related insulin secretion. Second-void fasting UCPCR was highly correlated with 24-h UCP (r = 0.8, P = 0.00006). Conclusions Second-void fasting UCPCR is…
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Urine post-meal C-peptide creatinine ratio is an alternative to serum C-peptide testing.
“Measurement of urine post meal C-peptide creatinine ratio (UCPCR) is an alternative to serum C-peptide testing(4–7).”
From Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors (2015) · cites this paper as [4]
UCPCR requires only a single spot urine sample and remains stable for 3 days at room temperature, which makes large community studies feasible because samples can be posted.
“UCPCR involves a single, spot urine measurement and has the advantage of long term stability (3 days) at room temperature which facilitates large scale community studies as samples can be posted.”
From Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors (2015) · cites this paper as [4]
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- Authors
- McDonald, T. J., Knight, B. A., Shields, B. M., Bowman, P., Salzmann, M. B., & Hattersley, A. T.
- Affiliations
- Peninsula NIHR Clinical Research Facility, Peninsula Medical School, Exeter, UK
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Corresponding author
- Hattersley, Andrew T
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-01
- Volume
- 55
- Issue
- 11
- Pages
- 2035-2039
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2148253529
- Cited by
- 75
- References
- 17
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- urinary C-peptide, sample stability, freeze-thaw cycles, endogenous insulin secretion, reproducibility
- MeSH terms
- Adult, C-Peptide, Creatinine, Fasting, Female, Freezing, Humans, Immunoassay, Male, Middle Aged, Temperature, Time Factors, Reproducibility of Results, Young Adult
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