The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay
Open accessAbstract
Background: We report the development of a novel high-sensitivity cardiac troponin T (hs-cTnT) assay, a modification of the Roche fourth-generation cTnT assay, and validation of the analytical performance of this assay. Methods: Validation included testing of analytical sensitivity, specificity, interferences, and precision. We established the 99th percentile cutoff from healthy reference populations (n = 616). In addition, we studied differences in time to a positive result when using serial measurements of hs-cTnT vs cTnT in patients with a confirmed diagnosis of non-ST elevation myocardial infarction (non-STEMI). Results: The hs-cTnT assay had an analytical range from 3 to 10 000 ng/L. At the 99th percentile value of 13.5 ng/L, the CV was 9% using the Elecsys® 2010 analyzer. The assay was specific for cTnT without interferences from human cTnI or cTnC, skeletal muscle TnT, or hemoglobin concentrations up to 1000 mg/L, above which falsely lower values would be expected. When the assay was evaluated clinically, a hs-cTnT higher than the 99th percentile concentration identified a significantly higher number of patients with non-STEMI on presentation (45 vs 20 patients, P = 0.0004) compared with cTnT, and a final diagnosis of non-STEMI was made in 9 additional patients (55 vs 46 patients, P = 0.23) after serial sampling. Time to diagnosis was significantly shorter using hs-cTnT compared with cTnT [mean 71.5 (SD 108.7) min vs 246.9 (82.0) min, respectively; P < 0.01]. Conclusions: The analytical performance of hs-cTnT complies with the ESC-ACCF-AHA-WHF Global Task Force recommendations for use in the diagnosis of MI.
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Self-citationEarly Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays
Reichlin, T., Hochholzer, W., Bassetti, S., Steuer, S., Stelzig, C., Hartwiger, S., Biedert, S., Schaub, N., Buerge, C., Potocki, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900428 · Cited by 1,687
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Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction
Keller, T., Zeller, T., Peetz, D., Tzikas, S., Roth, A., Czyz, E., Bickel, C., Baldus, S., Warnholtz, A., Fröhlich, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903515 · Cited by 1,150
Cardiac Troponin and Outcome in Acute Heart Failure
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Cited by
Third Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D. (2012) · Circulation · doi:10.1161/cir.0b013e31826e1058 · Cited by 2,985
Self-citationAnalytical Characteristics of High-Sensitivity Cardiac Troponin Assays
Apple, F. S., Collinson, P. O., & for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.165795 · Cited by 861
Third Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., White, H. D., & For the Universal Definition of MI, W. G. J. E. (2012) · Global Heart · doi:10.1016/j.gheart.2012.08.001 · Cited by 544
Self-citationBiomarkers in atrial fibrillation: a clinical review
Hijazi, Z., Oldgren, J., Siegbahn, A., Granger, C. B., & Wallentin, L. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht024 · Cited by 298
Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction
Twerenbold, R., Boeddinghaus, J., Nestelberger, T., Wildi, K., Rubini Gimenez, M., Badertscher, P., & Mueller, C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.718 · Cited by 255
Metadata
- Authors
- Giannitsis, E., Kurz, K., Hallermayer, K., Jarausch, J., Jaffe, A. S., & Katus, H. A.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02-01
- Volume
- 56
- Issue
- 2
- Pages
- 254-261
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2098105324
- Cited by
- 1,084
- References
- 24
- FWCI
- 35.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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