Third Universal Definition of Myocardial Infarction

Thygesen, Kristian; Alpert, Joseph S.; Jaffe, Allan S.; Simoons, Maarten L.; Chaitman, Bernard R.; White, Harvey D.

doi:10.1161/cir.0b013e31826e1058

Cited by 2,985Acute Myocardial Infarction ResearchCardiac Imaging and DiagnosticsCoronary Interventions and Diagnostics

Third Universal Definition of Myocardial Infarction

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Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., White, Harvey D.·2012·Circulation

DOI 10.1161/cir.0b013e31826e1058

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Cardiac fibrosis is prominent in patients with myocardial infarction and in those with ischaemic and non-ischaemic cardiomyopathies.
“cardiac fibrosis is prominent in patients who suffer a myocardial infarction (MI) and in those with ischaemic and non-ischaemic cardiomyopathies (ICM and NICM)5,6.”
From Targeting immune–fibroblast cell communication in heart failure (2024) · cites this paper as [6]
The imaging discussion says that ischaemia and infarction can lead to healing by fibrosis, supporting the MI portion of the claim. The passages on heart failure and cardiomyopathy do not say that fibrosis is prominent in ischaemic or non-ischaemic cardiomyopathies, and the paper does not establish how prominent fibrosis is among MI patients. Page numbers were not available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
In ancillary analyses using updated stroke and MI definitions, the effect of pioglitazone on the primary outcome was similar, with a hazard ratio of 0.73 (95% CI, 0.60 to 0.88).
“In ancillary analyses, the effect of pioglitazone on the primary outcome was similar when stroke and myocardial infarction were defined according to updated criteria28,29 (hazard ratio, 0.73; 95% CI, 0.60 to 0.88).”
From Pioglitazone after Ischemic Stroke or Transient Ischemic Attack (2016) · cites this paper as [29]

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Flagged first, then by citations

Research works printed but not linked: 5

Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J. 2007;28:2525-2538; Circulation. 2007;116:2634 -2653; J Am Coll Cardiol. 2007;50:2173-2195.
Morrow DA, Cannon CP, Jesse RL, Newby LK, Ravkilde J, Storrow AB, Wu AHB, Christenson RH. National Academy of Clinical Bio- chemistry Laboratory Medicine Practice Guidelines: Clinical character- istics and utilization of biochemical markers of acute coronary syn- dromes. Circulation. 2007;115:e356 -e375.
Stillman AE, Oudkerk M, Bluemke D, Bremerich J, Esteves FP, Garcia EV, Gutberlet M, Hundley WG, Jerosch-Herold M, Kuijpers D, Kwong RK, Nagel E, Lerakis S, Oshinski J, Paul JF, Underwood R, Winter- sperger BJ, Rees MR; North American Society of Cardiovascular Imag- ing;European Society of Cardiac Radiology. Int J Cardiovasc Imaging. 2011;27:7-24.
Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM. Mul- timodality imaging of myocardial injury and remodelling. J Nucl Med. 2010;51:p107S-121S.
White HD. The prequel. Defining prognostically important criteria in the periprocedural PCI troponin saga. Circ Cardiovasc Interv. 2012;5: 142-145.

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Authors: Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D.
Affiliations: Aarhus University Hospital (DK)
University of Arizona (US)
Auckland City Hospital (NZ)
ORCID: Thygesen, Kristian
Jaffe, Allan S.
Simoons, Maarten L.
Chaitman, Bernard R.
White, Harvey D.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-10-16
Volume: 126
Issue: 16
Pages: 2020-2035
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0b013e31826e1058
OpenAlex: W4292856638
Cited by: 2,985
References: 102
Citations by year: 2026: 68 · 2025: 127 · 2024: 164 · 2023: 147 · 2022: 179 · 2021: 202 · 2020: 278 · 2019: 294 · 2018: 359 · 2017: 316 · 2016: 280 · 2015: 239 · 2014: 199 · 2013: 120 · 2012: 8
FWCI: 116.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders: American Heart Association
American College of Cardiology Foundation
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
Keywords: myocardial infarction, diagnostic criteria, acute coronary syndrome, myocardial ischemia
MeSH terms: Cardiology, Diagnostic Techniques, Cardiovascular, Humans, Myocardial Infarction, Myocardial Ischemia

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Third Universal Definition of Myocardial Infarction

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