The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Plasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction
Abstract
Background: MicroRNAs (miRNAs) are endogenous small RNAs 21–25 nucleotides in length. Recently, we reported that miRNA 208 (miR-208) is produced exclusively in the rat myocardium and that plasma miR-208 is a biomarker of myocardial injury in rats. In the present study, we assessed the hypothesis that plasma concentrations of myocardial-specific miRNAs can be used to diagnose myocardial injury in humans. Methods: We used array analysis of miRNA production in various human tissues to identify heart-specific miRNAs. We assessed the plasma concentrations of miR-499 in 14 individuals with acute coronary syndromes, 15 individuals with congestive heart failure, and 10 individuals without cardiovascular diseases. Plasma miR-499 concentrations were measured with a real-time reverse-transcription PCR method that used an artificial small RNA as an internal calibrator. Results: The miRNA array analysis of various human tissues indicated that miR-499 was produced almost exclusively in the heart. Plasma miR-499 concentrations were measurably increased in all individuals with acute myocardial infarction but were below the limit of detection for all individuals in the other patient groups. Conclusions: The plasma concentration of miR-499 may be a useful biomarker of myocardial infarction in humans.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
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The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. E., & Galas, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813371106 · Cited by 1,149
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Cited by
Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease
Corsten, M. F., Dennert, R., Jochems, S., Kuznetsova, T., Devaux, Y., Hofstra, L., Wagner, D. R., Staessen, J. A., Heymans, S., & Schroen, B. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.957415 · Cited by 794
Methodological challenges in utilizing mi RNA s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436
Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run
Gomes, C. P. C., Oliveira-Jr, G. P., Madrid, B., Almeida, J. A., Franco, O. L., & Pereira, R. W. (2014) · Biomarkers · doi:10.3109/1354750x.2014.952663 · Cited by 92
All’s well that transcribes well: Non-coding RNAs and post-stroke brain damage
Vemuganti, R. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.07.014 · Cited by 71
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0065-0 · Cited by 13
Metadata
- Authors
- Adachi, T., Nakanishi, M., Otsuka, Y., Nishimura, K., Hirokawa, G., Goto, Y., Nonogi, H., & Iwai, N.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-01
- Volume
- 56
- Issue
- 7
- Pages
- 1183-1185
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1986686379
- Cited by
- 383
- References
- 7
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
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