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Cited by 47Schizophrenia research and treatmentGenetic Associations and EpidemiologyPersonality Traits and Psychology

Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study

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Hay, David A., Martin, Nicholas G., Foley, Debra, Treloar, Susan A., Kirk, Katherine M., Heath, Andrew C.·2001·Twin Research
DOI 10.1375/twin.4.1.30
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Abstract

Previous genetic analyses of psychosis proneness have been limited by their small sample size. For the purposes of large-scale screening, a 12-item questionnaire was developed through a two-stage process of reduction from the full Chapman and Chapman scales. 3685 individuals (including 1438 complete twin pairs) aged 18-25 years and enrolled in the volunteer Australian Twin Registry returned a mail questionnaire which included this psychosis proneness scale and the Eysenck Personality Questionnaire. Despite the brevity of the questionnaire, item and factor analysis identified four unambiguous and essentially uncorrelated scales. There were (1) Perceptual Aberration--Magical Ideation; (2) Hypomania--Impulsivity/Nonconformity; (3) Social Anhedonia and (4) Physical Anhedonia. Model-fitting analyses showed additive genetic and specific environmental factors were sufficient for three of the four scales, with the Social Anhedonia scale requiring also a parameter for genetic dominance. There was no evidence for the previously hypothesised sex differences in the genetic determination of psychosis-proneness. The potential value of multivariate genetic analysis to examine the relationship between these four scales and dimensions of personality is discussed. The growing body of longitudinal evidence on psychosis-proneness suggests the value of incorporating this brief measure into developmental twin studies.

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  • Multivariate studies from the general population indicate that social anhedonia is genetically conferred.

    “Certainly, multivariate studies from the general population have pointed to social anhedonia being genetically conferred (153, 154).”

    From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [153]

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Research works printed but not linked: 2

  1. Chapman, J.P., & Chapman, L.J. (1985). Psychosis Proneness. In M. Albert (Ed.) Controversies in Schizophrenia (pp 152-174). New York: Guilford Press.
  2. Kasriel, J., & Eaves, L.J. (1976). The zygosity of twins: further evi- dence on the agreement between diagnosis by bloodgroups and written questionnaire. Journal of Biosocial Science, 8, 263-266.

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Authors
Hay, D. A., Martin, N. G., Foley, D., Treloar, S. A., Kirk, K. M., & Heath, A. C.
Affiliations
  • Curtin University (AU)
  • The University of Queensland (AU)
  • Virginia Commonwealth University Medical Center (US)
Corresponding author
Hay, David A.
ORCID
Venue
Twin Research
Publisher
Cambridge University Press (CUP)
Published
2001-02-01
Volume
4
Issue
1
Pages
30-40
ISSN
  • 1369-0523 (ISSN-L)
  • 2053-6003
DOI
10.1375/twin.4.1.30
OpenAlex
W2160692566
Cited by
47
References
64
Citations by year
2024: 1 · 2023: 1 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 4037 d)
Locations
  • Twin Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council (941177)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA007535, AA-07535, AA-07728)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Keywords
psychosis proneness, twin studies, heritability, additive genetic effects, genetic dominance, social anhedonia, physical anhedonia, magical ideation, hypomania, impulsivity, nonconformity, personality factors, sex differences, Eysenck Personality Questionnaire, Australian Twin Registry
MeSH terms
Adolescent, Adult, Australia, Factor Analysis, Statistical, Female, Humans, Male, Phenotype, Psychological Tests, Psychotic Disorders, Surveys and Questionnaires, Registries, Twins, Dizygotic, Twins, Monozygotic, Reproducibility of Results, Sample Size, Twin Studies as Topic

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