Obstacles and opportunities in Alzheimer’s clinical trial recruitment
Open accessAbstract
The 2012 National Plan to Address Alzheimer's Disease set an ambitious goal: to both prevent and effectively treat Alzheimer's disease by 2025. To reach this goal, tens of thousands of volunteers will be needed to participate in clinical trials to test promising new interventions and therapies. To mobilize these volunteers and their health care providers to participate in future clinical trials, it will be necessary to achieve a better understanding of the barriers keeping people from participating in Alzheimer's research; form innovative partnerships among researchers, health care and social service providers, and the public; and develop more-effective outreach strategies. In this article we explore recruitment issues, including those unique to Alzheimer's studies, and we suggest concrete steps such as establishing a structured consortium linking all of the registries of Alzheimer's trials and establishing new partnerships with community and local organizations that can build trust and understanding among patients, caregivers, and providers.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Data at preclinical and prodromal stages, particularly longitudinal biomarkers, are critically insufficient due to low screening participation, invasive sampling requirements, and reliance on caregiver-reported cognitive changes.
“critically insufficient data at preclinical and prodromal stages, particularly longitudinal biomarkers, due to low screening participation, invasive sampling requirements, and reliance on caregiver-reported cognitive changes (Watson et al., 2014)”
From Multimodal neuroimaging and AI integration in cognitive disorders: advances, challenges, and future directions for precision medicine (2026) · cites this paper as Watson et al., 2014
The “Challenges To Alzheimer’s Trial Recruitment” section identifies invasive procedures and the need for a study partner to report cognitive changes as recruitment barriers. “New Challenge: Presymptomatic Alzheimer’s Disease Trials” says recruiting and screening large numbers of volunteers will be difficult. The paper does not establish that preclinical or prodromal data—particularly longitudinal biomarker data—are critically insufficient, or attribute such a shortage to low screening participation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · see citing works
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,630 · see citing works
Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan
Tang, M. ‐., Cross, P. S., Andrews, H., Jacobs, D. M., Small, S. A., Bell, K., Merchant, C., Lantigua, R., Costa, R., Stern, Y., et al. (2001) · Neurology · doi:10.1212/wnl.56.1.49 · Cited by 721 · see citing works
Testing the Right Target and Right Drug at the Right Stage
Sperling, R. A., Jack, C. R., & Aisen, P. S. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002609 · Cited by 550 · see citing works
Lin, J. S., O’Connor, E., Rossom, R. C., Perdue, L. A., & Eckstrom, E. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-9-201311050-00730 · Cited by 412 · see citing works
Physician Recognition of Cognitive Impairment: Evaluating the Need for Improvement
Chodosh, J., Petitti, D. B., Elliott, M. N., Hays, R. D., Crooks, V. C., Reuben, D. B., Buckwalter, J. G., & Wenger, N. S. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52301.x · Cited by 350 · see citing works
Grill, J. D., & Karlawish, J. H. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt58 · Cited by 196 · see citing works
Siemers, E., Friedrich, S. W., Dean, R. A., Gonzales, C., Farlow, M. R., Paul, S. M., & Demattos, R. B. (2010) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181cb577a · Cited by 192 · see citing works
Recruitment of a Community-based Cohort for Research on Diversity and Risk of Dementia
Hinton, L., Carter, K., Reed, B., Beckett, L. A., Lara, E., DeCarli, C. S., & Mungas, D. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181c1ee01 · Cited by 114 · see citing works
Facilitating Alzheimer Disease Research Recruitment
Grill, J. D., & Galvin, J. E. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000016 · Cited by 112 · see citing works
How redesigning AD clinical trials might increase study partners’ willingness to participate
Karlawish, J. H., Cary, M. S., Rubright, J. D., & Tenhave, T. (2008) · Neurology · doi:10.1212/01.wnl.0000336652.05779.ea · Cited by 83 · see citing works
Jefferson, A. L., Lambe, S. A., Chaisson, C. E., Palmisano, J. N., Horvath, K. J., & Karlawish, J. H. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101536 · Cited by 72 · see citing works
Effect of study partner on the conduct of Alzheimer disease clinical trials
Grill, J. D., Raman, R., Ernstrom, K. B., Aisen, P. S. S., & Karlawish, J. H. (2012) · Neurology · doi:10.1212/wnl.0b013e31827debfe · Cited by 70 · see citing works
Recruitment of Chinese American Elders into Dementia Research: The UCSF ADRC Experience
Chao, S. Z., Lai, N. B., Tse, M. M., Ho, R. J., Kong, J., Matthews, B. R., Miller, B. L., & Rosen, H. J. (2011) · The Gerontologist · doi:10.1093/geront/gnr033 · Cited by 51 · see citing works
Vellas, B. J., Hampel, H. J., Bugat, M.-È. R., Grundman, M., Andrieu, S., Abushakra, S. R., Bateman, R. J., Berman, R., Black, R. S., Carrillo, M. C., et al. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0044-x · Cited by 45 · see citing works
Ballard, E. L., Gwyther, L. P., & Edmonds, H. L. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181f12432 · Cited by 41 · see citing works
Recruitment and enrollment of caregivers for a lifestyle physical activity clinical trial
Etkin, C. D., Farran, C. J., Barnes, L. L., & Shah, R. C. (2011) · Research in Nursing & Health · doi:10.1002/nur.20466 · Cited by 37 · see citing works
Carr, S. A., Davis, R., Spencer, D., Smart, M., Hudson, J., Freeman, S., Cooper, G. E., Schmitt, F. A., Markesbery, W. R., Danner, D. D., et al. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181aba927 · Cited by 36 · see citing works
Predictors of Physician Referral for Patient Recruitment to Alzheimer Disease Clinical Trials
Galvin, J. E., Meuser, T. M., Boise, L., & Connell, C. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819e0cac · Cited by 36 · see citing works
Dowling, N. M., Olson, N., Mish, T., Kaprakattu, P., & Gleason, C. E. (2012) · Clinical Trials · doi:10.1177/1740774511432555 · Cited by 33 · see citing works
Dilworth‐Anderson, P., & Cohen, M. D. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181f12755 · Cited by 22 · see citing works
Recruitment methods for united states Alzheimer disease prevention trials
Schneider, L. S. (2012) · The Journal of nutrition, health and aging · doi:10.1007/s12603-012-0011-6 · Cited by 22 · see citing works
Physicians and caregivers: Ready and waiting for increased participation in clinical research
Jones, R. W., Andrieu, S., Knox, S., & Mackell, J. A. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0269-5 · Cited by 20 · see citing works
Dementia Screening in Primary Care: Not Too Fast!
Boustani, M. A. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12319_2 · Cited by 20 · see citing works
Hampel, H. J., & Prvulovic, D. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0021-4 · Cited by 11 · see citing works
The Case for Screening for Cognitive Impairment in Older Adults
McCarten, J. R. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12319_1 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [5]Weisfeld V English RA Claiborne AB Public engagement and clinical trials: new models and disruptive technologies [Internet] Washington (DC) National Academies Press 2011 2013 Nov 13 Available from: http://www.iom.edu/Reports/2011/Public-Engagement-and-Clinical-Trials-New-Models-and-Disruptive-Technologies-Workshop-Summary.aspx
Cited by
Sorted by citations
2022 Alzheimer's disease facts and figures
Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,384 · see citing works
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,236 · see citing works
Gold, M., Amatniek, J. C., Carrillo, M. C., Cedarbaum, J. M., Hendrix, J. A., Miller, B. B., Robillard, J. M., Rice, J. J., Soares, H. D., Tome, M. B., et al. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.04.003 · Cited by 146 · see citing works
Fargo, K. N., Carrillo, M. C., Weiner, M. W., Potter, W. Z., & Khachaturian, Z. S. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.10.001 · Cited by 123 · see citing works
Lim, J., Walley, R. J., Yuan, J., Liu, J., Dabral, A., Best, N., Grieve, A. P., Hampson, L. V., Wolfram, J., Woodward, P., et al. (2018) · Therapeutic Innovation & Regulatory Science · doi:10.1177/2168479018778282 · Cited by 120 · see citing works
Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials
Langbaum, J. B. S., Zissimopoulos, J., Au, R., Bose, N., Edgar, C. J., Ehrenberg, E., Fillit, H. M., Hill, C. V., Hughes, L., Irizarry, M. C., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12737 · Cited by 116 · see citing works
Clinical Trials in Alzheimer’s Disease: A Hurdle in the Path of Remedy
Oxford, A. E., Stewart, E. S., & Rohn, T. T. (2020) · International Journal of Alzheimer s Disease · doi:10.1155/2020/5380346 · Cited by 109 · see citing works
Gleason, C. E., Norton, D., Zuelsdorff, M. L., Benton, S. F., Wyman, M. F., Nystrom, N. C., Lambrou, N. H., Salazar, H., Koscik, R. L., Jonaitis, E. M., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.015 · Cited by 98 · see citing works
African Americans are less likely to enroll in preclinical Alzheimer's disease clinical trials
Zhou, Y. F., Elashoff, D. A., Kremen, S. A., Teng, E., Karlawish, J. H., & Grill, J. D. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.09.004 · Cited by 97 · see citing works
Indorewalla, K. K., O’Connor, M. K., Budson, A. E., Guess (DiTerlizzi), C., & Jackson, J. (2021) · Journal of Alzheimer’s Disease · doi:10.3233/jad-201081 · Cited by 93 · see citing works
The Precarity of Older Adults Living Alone With Cognitive Impairment
Portacolone, E., Rubinstein, R. L., Covinsky, K. E., Halpern, J., & Johnson, J. K. (2017) · The Gerontologist · doi:10.1093/geront/gnx193 · Cited by 86 · see citing works
Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials
Goldman, J. G., Forsberg, L. K., Boeve, B. F., Armstrong, M. J., Irwin, D. J., Ferman, T. J., Galasko, D. R., Galvin, J. E., Kaufer, D., Leverenz, J. B., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00703-5 · Cited by 62 · see citing works
Langbaum, J. B., High, N. M., Nichols, J. B., Kettenhoven, C. L., Reiman, E. M., & Tariot, P. N. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.31 · Cited by 60 · see citing works
James, S., Lane, C., Parker, T. D., Lu, K., Collins, J. D., Murray‐Smith, H., Byford, M., Wong, A., Keshavan, A., Buchanan, S. M., et al. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3995-0 · Cited by 59 · see citing works
Langbaum, J. B. S., Karlawish, J. H., Roberts, J. S., Wood, E. M., Bradbury, A. R., High, N. M., Walsh, T. L., Gordon, D., Aggarwal, R., Davis, P., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.007 · Cited by 57 · see citing works
Salazar, C. R., Hoang, D. K., Gillen, D. L., & Grill, J. D. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12023 · Cited by 54 · see citing works
Aisen, P. S. S., Touchon, J., Andrieu, S., Boada, M., Doody, R. S., Nosheny, R. L., Langbaum, J. B., Schneider, L. S., Hendrix, S. B., Wilcock, G. K., et al. (2016) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2016.97 · Cited by 53 · see citing works
Park, V. T., Meyer, O. L., Tsoh, J. Y., Kanaya, A. M., Tzuang, M., Nam, B., Vuong, Q. N., Bang, J., Hinton, L., Gallagher-Thompson, D. E., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12667 · Cited by 52 · see citing works
McCoy, T. H., Han, L., Pellegrini, A. M., Tanzi, R. E., Berretta, S., & Perlis, R. H. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.09.084 · Cited by 51 · see citing works
Aranda, M., Márquez, D. X., Gallagher-Thompson, D. E., Pérez, A., Rojas, J. C., Hill, C. V., Reyes, Y., Dilworth‐Anderson, P., & Portacolone, E. (2023) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12389 · Cited by 50 · see citing works
Grill, J. D., Hoang, D. K., Gillen, D. L., Cox, C. G., Gombosev, A., Klein, K. G., O’Leary, S., Witbracht, M. G., & Pierce, A. L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180069 · Cited by 49 · see citing works
Study partners: essential collaborators in discovering treatments for Alzheimer’s disease
Largent, E. A., Karlawish, J. H., & Grill, J. D. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0425-4 · Cited by 48 · see citing works
Mirkin, S., & Albensi, B. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1094233 · Cited by 46 · see citing works
Jeon, Y., Shin, M., Smith, A. M., Beattie, E., Brodaty, H., Frost, D., Hobbs, A., Kotting, P. M., Petrie, G., Rossor, M. N., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111353 · Cited by 46 · see citing works
Attitudes toward clinical trials across the Alzheimer’s disease spectrum
Nuño, M. M., Gillen, D. L., Dosanjh, K. K., Brook, J. K., Elashoff, D. A., Ringman, J. M., & Grill, J. D. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0311-5 · Cited by 46 · see citing works
Massett, H. A., Mitchell, A. K., Alley, L., Simoneau, E., Burke, P., Han, S. H., Gallop‐Goodman, G., & McGowan, M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201463 · Cited by 46 · see citing works
Márquez, D. X., Pérez, A., Johnson, J. K., Jaldin, M., Pinto, J., Keiser, S., Tran, T., Martinez, P., Guerrero, J., & Portacolone, E. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12331 · Cited by 45 · see citing works
Online study partner‐reported cognitive decline in the Brain Health Registry
Nosheny, R. L., Camacho, M. R., Insel, P. S., Flenniken, D., Fockler, J., Truran, D., Finley, S., Ulbricht, A., Maruff, P. T., Yaffe, K. S., et al. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.09.008 · Cited by 44 · see citing works
Earning the Trust of African American Communities to Increase Representation in Dementia Research
Portacolone, E., Palmer, N. R., Lichtenberg, P. A., Waters, C. M., Hill, C. V., Keiser, S., Vest, L., Maloof, M., Tran, T., Martinez, P., et al. (2020) · Ethnicity & Disease · doi:10.18865/ed.30.s2.719 · Cited by 44 · see citing works
Park, V. T., Dougan, M., Meyer, O. L., Nam, B., Tzuang, M., Park, L. G., Vuong, Q. N., Bang, J., & Tsoh, J. Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020924 · Cited by 43 · see citing works
Clement, C., Selman, L. E., Kehoe, P. G., Howden, B., Lane, J. A., & Horwood, J. P. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190146 · Cited by 42 · see citing works
Lincoln, K. D., Chow, T., Gaines, B. F., & Fitzgerald, T. (2021) · Ethnicity & Health · doi:10.1080/13557858.2018.1539222 · Cited by 38 · see citing works
Jang, H., Soroski, T., Rizzo, M., Barral, O., Harisinghani, A., Newton‐Mason, S. M., Granby, S., Vasco, T. D. C., Lewis, C., Tutt, P., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.716670 · Cited by 37 · see citing works
Ansart, M., Epelbaum, S., Gagliardi, G. P., Olivier Colliot, A., Dormont, D., Dubois, B., Hampel, H. J., Durrleman, S., & Initiative, A. D. N. (2019) · Statistical Methods in Medical Research · doi:10.1177/0962280218823036 · Cited by 36 · see citing works
Nosheny, R. L., Amariglio, R. E., Sikkes, S. A. M., Hulle, C. V., Bicalho, M. A. C., Dowling, N. M., Brucki, S. M. D., Ismail, Z., Kasuga, K., Kuhn, E., et al. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12357 · Cited by 36 · see citing works
Varma, V. R., Ghosal, R., Hillel, I., Volfson, D., Weiss, J., Urbanek, J. K., Hausdorff, J. M., Zipunnikov, V., & Watts, A. S. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12131 · Cited by 34 · see citing works
Park, V. T., Dougan, M., Meyer, O. L., Nam, B., Tzuang, M., Park, L. G., Vuong, Q. N., & Tsoh, J. Y. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101480 · Cited by 34 · see citing works
Dave, B. P., Shah, Y. B., Maheshwari, K. G., Mansuri, M. K. A., Prajapati, B., Postwala, H. I., & Chorawala, M. R. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01408-7 · Cited by 32 · see citing works
Study, F. T. A. D. C., Nuño, M. M., Gillen, D. L., & Grill, J. D. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0544-6 · Cited by 31 · see citing works
Luca, D. G. D., Sambursky, J. A., Margolesky, J. H., Cordeiro, J. G., Diaz, A., Shpiner, D. S., Moore, H. P., Singer, C., & Luca, C. C. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202045 · Cited by 31 · see citing works
Accelerating Alzheimer's disease drug innovations from the research pipeline to patients
Goldman, D. P., Fillit, H., & Neumann, P. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.007 · Cited by 30 · see citing works
Predicting Onset of Dementia Using Clinical Notes and Machine Learning: Case-Control Study
Hane, C. A., Nori, V. S., Crown, W. H., Sanghavi, D. M., & Bleicher, P. A. (2020) · JMIR Medical Informatics · doi:10.2196/17819 · Cited by 30 · see citing works
Kim, H. J., & Fraser, S. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10944-5 · Cited by 30 · see citing works
Retaining Participants in Longitudinal Studies of Alzheimer’s Disease
Gabel, M. J., Bollinger, R. M., Coble, D. W., Grill, J. D., Edwards, D. F., Lingler, J. H., Chin, E. M., & Stark, S. L. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215710 · Cited by 30 · see citing works
The Burden of a Remote Trial in a Nursing Home Setting: Qualitative Study
Donnelly, S., Reginatto, B., Kearns, O., Carthy, M. M., Byrom, B., Muehlhausen, W., & Caulfield, B. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9638 · Cited by 29 · see citing works
Cox, C. G., Mary M. Ryan, B. A., Gillen, D. L., & Grill, J. D. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.10.016 · Cited by 28 · see citing works
Fostering the Resilience of People With Dementia: A Narrative Literature Review
Whelan, S., Teahan, Á., & Casey, D. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00045 · Cited by 28 · see citing works
Park, V. T., Grill, J. D., Zhu, J., Nguyen, K., Nam, B., Tsoh, J. Y., Kanaya, A. M., Vuong, Q. N., Bang, J., Nguyen, N. N., et al. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12195 · Cited by 27 · see citing works
Main plant extracts’active properties effective on scopolamine-induced memory loss
Balmus, I.-M., & Ciobica, A. (2017) · American Journal of Alzheimer's Disease & Other Dementiasr · doi:10.1177/1533317517715906 · Cited by 25 · see citing works
Validity of Cognitive Assessment Tools for Older Adult Hispanics: A Systematic Review
Arévalo, S., Kreß, J., & Rodriguez, F. S. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16300 · Cited by 25 · see citing works
Soroski, T., Vasco, T. D. C., Newton‐Mason, S. M., Granby, S., Lewis, C., Harisinghani, A., Rizzo, M., Conati, C., Murray, G., Carenini, G., et al. (2022) · JMIR Aging · doi:10.2196/33460 · Cited by 25 · see citing works
Bardach, S. H., Yarbrough, M., Walker, C., Alfred, D. L., Ighodaro, E. T., Kiviniemi, M. T., & Jicha, G. A. (2020) · Journal of Applied Gerontology · doi:10.1177/0733464820902002 · Cited by 25 · see citing works
Vaghari, D., Mohankumar, G., Tan, K., Lowe, A., Shering, C., Peter Tiňo, B., & Kourtzi, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-61355-3 · Cited by 24 · see citing works
Boada, M., Santos‐Santos, M., Rodríguez‐Gómez, O., Alegret, M., Cañabate, P., Lafuente, A., Ruiz, C. A., Buendía, M., de Dios, M. J., Morera, A., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170866 · Cited by 24 · see citing works
Uspenskaya, O., Alamuri, C., Wang, L., Yang, M., Khinda, S., Nigmatullina, Y., Cao, T., Kayal, N., O’Keefe, M., & Rubel, C. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.10 · Cited by 23 · see citing works
Mindt, M. R., Arentoft, A., Calcetas, A. T., Guzman, V. A., Amaza, H., Ajayi, A. O., Ashford, M. T., Ayo, O., Barnes, L. L., Camuy, A. M., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14242 · Cited by 22 · see citing works
Ashford, M. T., Aaronson, A., Kwang, W., Eichenbaum, J., Gummadi, S. L., Jin, C., Cashdollar, N. M., Thorp, E., Wragg, E., Zavitz, K. H., et al. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.117 · Cited by 22 · see citing works
Recruiting to preclinical Alzheimer's disease clinical trials through registries
Grill, J. D. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.02.004 · Cited by 22 · see citing works
Clinical Trials and Tribulations in the COVID-19 Era
Weinberg, M. S., Patrick, R. E., Schwab, N. A., Owoyemi, P., May, R., McManus, A. J., Gerber, J. A., Harper, D. G., Arnold, S. E., & Forester, B. P. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.05.016 · Cited by 22 · see citing works
Recruitment of Older Adults With Dementia for Research: An Integrative Review
Davis, R., & Bekker, P. (2022) · Research in Gerontological Nursing · doi:10.3928/19404921-20220830-04 · Cited by 21 · see citing works
Motivators for Alzheimer’s disease clinical trial participation
Bardach, S. H., Holmes, S., & Jicha, G. A. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0771-2 · Cited by 21 · see citing works
TRC-PAD: Accelerating Recruitment of AD Clinical Trials through Innovative Information Technology
Jimenez‐Maggiora, G. A., Bruschi, S., Raman, R., Langford, O., Donohue, M., Rafii, M. S., Sperling, R. A., Cummings, J. L., & Aisen, P. S. S. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.48 · Cited by 21 · see citing works
Benson, C., Friz, A. M., Mullen, S. L., Block, L., & Gilmore‐Bykovskyi, A. L. (2020) · Journal of Empirical Research on Human Research Ethics · doi:10.1177/1556264620974898 · Cited by 21 · see citing works
Cashin, Z., Daley, S., Hebditch, M., Hughes, L., & Banerjee, S. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218001357 · Cited by 20 · see citing works
Bernstein, O. M., Grill, J. D., & Gillen, D. L. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00762-8 · Cited by 19 · see citing works
Ritter, A. R., Cummings, J. L., Nance, C., & Miller, J. B. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.006 · Cited by 18 · see citing works
The Effect of Heterogeneous Data for Alzheimer's Disease Detection from SpeechPreprint
Balagopalan, A., Novikova, J., Rudzicz, F., & Ghassemi, M. (2018) · arXiv (Cornell University) · doi:10.48550/arxiv.1811.12254 · Cited by 18 · see citing works
Analysis of eligibility criteria in Alzheimer’s and related dementias clinical trials
Mitchell, A. K., Ehrenkranz, R. C., Franzen, S., Han, S. H., Shakur, M., McGowan, M., & Massett, H. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-65767-x · Cited by 17 · see citing works
Guan, D. X., Mudalige, D. M., Munro, C. E., Nosheny, R. L., Smith, E. E., & Ismail, Z. (2024) · International Psychogeriatrics · doi:10.1017/s1041610224000590 · Cited by 17 · see citing works
Research attitudes in families of individuals with Down syndrome: importance for clinical trials
Lott, I. T., Kirby, K. A., Doran, E. W., & Grill, J. D. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01120-6 · Cited by 17 · see citing works
Cocroft, S., Welsh‐Bohmer, K. A., Plassman, B. L., Chanti‐Ketterl, M., Edmonds, H., Gwyther, L., McCart, M., MacDonald, H., Potter, G., & Burke, J. R. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12048 · Cited by 16 · see citing works
Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials
Brenowitz, W. D., & Yaffe, K. S. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00733-7 · Cited by 16 · see citing works
Cox, C. G., Davis, M., Grill, J. D., & Roberts, J. S. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.86 · Cited by 16 · see citing works
A unified model of dementias and age‐related neurodegeneration
Fossel, M. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12012 · Cited by 16 · see citing works
Mindt, M. R., Ashford, M. T., Zhu, D., Cham, H., Aaronson, A., Conti, C. C., Deng, X., Alaniz, R., Sorce, J., Cypress, C., et al. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.32 · Cited by 16 · see citing works
Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies
Rizzo, S. J. S., McTighe, S. M., & McKinzie, D. L. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_282 · Cited by 16 · see citing works
Dabiri, S., Raman, R. K., Grooms, J., & Molina‐Henry, D. P. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.149 · Cited by 15 · see citing works
Which MCI Patients Should be Included in Prodromal Alzheimer Disease Clinical Trials?
Grill, J. D., Nuño, M. M., & Gillen, D. L. (2019) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000303 · Cited by 15 · see citing works
Ability and Willingness to Participate in Dementia Clinical Research: A Qualitative Study
Bouranis, N., Gelmon, S. B., & Lindauer, A. (2023) · Patient · doi:10.1007/s40271-023-00621-2 · Cited by 14 · see citing works
Promoting Independence in Dementia (PRIDE): A Feasibility Randomized Controlled Trial
Csipke, E., Shafayat, A., Sprange, K., Bradshaw, L. E., Montgomery, A. A., Ogollah, R. O., Moniz-Cook, E. D., & Orrell, M. W. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s281139 · Cited by 14 · see citing works
ON LIVING ALONE WITH ALZHEIMER’S DISEASE
Portacolone, E. (2018) · Care weekly · doi:10.14283/cw.2018.3 · Cited by 14 · see citing works
Park, V. T., Grill, J. D., Tsoh, J. Y., Meyer, O. L., Ameli, N., Helman, S., Tzuang, M., Nam, B., Hinton, L., Kanaya, A. M., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13091 · Cited by 13 · see citing works
Promising Natural Remedies for Alzheimer’s Disease Therapy
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2025) · Molecules · doi:10.3390/molecules30040922 · Cited by 13 · see citing works
Parker, L. J., Gaugler, J. E., & Gitlin, L. N. (2022) · The Gerontologist · doi:10.1093/geront/gnac001 · Cited by 13 · see citing works
Salazar, C. R., Tallakson, M. B., Corona, M. G., Duran, E., Russ, E., Hoang, D. K., Romero, R. A., Sultzer, D. L., Grill, J. D., & Shin, H. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14211 · Cited by 12 · see citing works
Ottenhoff, L., Vijverberg, E. G. B., Visser, L. N. C., Verrijp, M., Prins, N. D., van der Flier, W. M., & Sikkes, S. A. M. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01190-0 · Cited by 12 · see citing works
Reasons for undergoing amyloid imaging among cognitively unimpaired older adults
Ryan, M. M., Gillen, D. L., & Grill, J. D. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51414 · Cited by 12 · see citing works
Behl, T., Kaur, I., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., Bhatia, S., & BUNGAU, S. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113179 · Cited by 11 · see citing works
Deoni, S., Burton, P., Beauchemin, J., Cano-Lorente, R., Both, M. D. D., Johnson, M. M., Ryan, L., & Huentelman, M. J. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02595-7 · Cited by 11 · see citing works
Self-citationThe Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive Review
Meshref, M. M., Ghaith, H. S., Hammad, M. A., Shalaby, M. M. M., Ayasra, F., Monib, F. A., Attia, M. S., Ebada, M. A., Elsayed, H., Shalash, A., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03802-0 · Cited by 11 · see citing works
Recruiting Persons with Dementia and Caregivers in a Clinical Trial: Dyads Perceptions
McPhillips, M., Petrovsky, D., Brewster, G. S., Li, J., Gooneratne, N. S., Hodgson, N. A., & Sefcik, J. S. (2021) · Western Journal of Nursing Research · doi:10.1177/01939459211008563 · Cited by 11 · see citing works
Retention of Study Partners in Longitudinal Studies of Alzheimer Disease
Bollinger, R. M., Gabel, M. J., Coble, D. W., Chen, S., Keleman, A. A., Doralus, J., Chin, E. M., Lingler, J. H., Grill, J. D., Stark, S. L., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230079 · Cited by 11 · see citing works
Validity of Online Versus In-Clinic Self-Reported Everyday Cognition Scale
Howell, T., Neuhaus, J. M., Glymour, M. M., Weiner, M. W., & Nosheny, R. L. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.20 · Cited by 10 · see citing works
Latino and Alzheimer’s: Social Determinants and Personal Factors Contributing to Disease Risk
Wu, S., Rodriguez, F., Jin, H.-M., & Vega, W. (2018) · Contextualizing Health and Aging in the Americas · doi:10.1007/978-3-030-00584-9_4 · Cited by 10 · see citing works
Assfaw, A. D., Babulal, G. M., Balls‐Berry, J. E., Mozersky, J. T., Moulder, K. L., & Morris, J. C. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70459 · Cited by 9 · see citing works
Jimenez‐Maggiora, G. A., Bruschi, S., Qiu, H., So, J., & Aisen, P. S. S. (2022) · JAMIA Open · doi:10.1093/jamiaopen/ooab119 · Cited by 9 · see citing works
Bennett, B., Freckelton, I. R., & Wolf, G. (2023) · doi:10.1093/oso/9780192896742.001.0001 · Cited by 9 · see citing works
Ryan, M. M., Cox, C. G., Witbracht, M. G., Hoang, D. K., Gillen, D. L., & Grill, J. D. (2020) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000421 · Cited by 9 · see citing works
Reuland, M., Sloan, D. H., Antonsdottir, I. M., Spliedt, M., Johnston, M. C. D., & Samus, Q. M. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106622 · Cited by 9 · see citing works
Diversifying Recruitment Registries: Considering Neighborhood Health Metrics
Grill, J. D., Kind, A., Hoang, D., & Gillen, D. L. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2021.50 · Cited by 8 · see citing works
- Authors
- Watson, J. L., Ryan, L., Silverberg, N., Cahan, V., & Bernard, M. A.
- Affiliations
- National Institutes of Health (US)
- National Institute on Aging (US)
- ORCID
- Bernard, Marie A.
- Venue
- Health Affairs
- Publisher
- Health Affairs Publishing, LLC
- Published
- 2014-04
- Volume
- 33
- Issue
- 4
- Pages
- 574-579
- ISSN
- 0278-2715 (ISSN-L)
- 1544-5208
- PMC
- PMC4167360
- OpenAlex
- W2044038526
- Cited by
- 204
- References
- 26
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 16 · 2023: 44 · 2022: 32 · 2021: 25 · 2020: 20 · 2019: 14 · 2018: 19 · 2017: 7 · 2016: 3
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Affairs (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, clinical trial recruitment, barriers to participation, research volunteers, community partnerships, outreach strategies, research registry
- MeSH terms
- Alzheimer Disease, Clinical Trials as Topic, Humans, Minority Groups, Registries, Patient Selection, Physicians, Primary Care, Asymptomatic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
