Mucins, Mucus, and Sputum
Abstract
Normal airway mucus lines the epithelial surface and provides an important innate immune function by detoxifying noxious molecules and by trapping and removing pathogens and particulates from the airway via mucociliary clearance. The major macromolecular constituents of normal mucus, the mucin glycoproteins, are large, heavily glycosylated proteins with a defining feature of tandemly repeating sequences of amino acids rich in serine and threonine, the linkage sites for large carbohydrate structures. The mucins are composed of two major families: secreted mucins and membrane-associated mucins. Membrane-associated mucins have been reported to function as cell surface receptors for pathogens and to activate intracellular signaling pathways. The biochemical and cellular functions for secreted mucin glycoproteins have not been definitively assigned. In contrast to normal mucus, sputum production is the hallmark of chronic inflammatory airway diseases such as asthma, chronic bronchitis, and cystic fibrosis (CF). Sputum has altered macromolecular composition and biophysical properties which vary with disease, but unifying features are failure of mucociliary clearance, resulting in airway obstruction, and failure of innate immune properties. Mucin glycoprotein overproduction and hypersecretion are common features of chronic inflammatory airway disease, and this has been the underlying rationale to investigate the mechanisms of mucin gene regulation and mucin secretion. However, in some pathologic conditions such as CF, airway sputum contains little intact mucin and has increased content of several macromolecules including DNA, filamentous actin, lipids, and proteoglycans. This review will highlight the most recent insights on mucus biology in health and disease.
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The differential effects of rhinovirus versus measles/adenovirus on bacterial adherence suggest a virus-specific induced change on the host cell membrane to which all bacteria adhered in the same way.
“suggesting a virus-specific induced change on the host cell membrane to which all bacteria adhered in the same way (96, 259, 302).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
Increased pneumococcal adherence was found after prior adenovirus or rhinovirus infection of airway epithelial cells.
“and increased pneumococcal adherence was found after prior adenovirus or rhinovirus infection of airway epithelial cells (93, 302).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
Measles virus and adenovirus infection decreased adherence of both bacterial species.
“whereas measles virus and adenovirus infection decreased adherence of both bacterial species”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
Rhinovirus preinfection enhanced staphylococcal and streptococcal adherence.
“Interestingly, rhinovirus preinfection enhanced staphylococcal and streptococcal adherence, whereas measles virus and adenovirus infection decreased adherence of both bacterial species”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [302]
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- Authors
- Voynow, J. A., & Rubin, B. K.
- Affiliations
- Duke University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Voynow, Judith A.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 135
- Issue
- 2
- Pages
- 505-512
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2148736553
- Cited by
- 504
- References
- 84
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 26 · 2022: 17 · 2021: 27 · 2020: 33 · 2019: 27 · 2018: 28 · 2017: 34 · 2016: 27 · 2015: 39 · 2014: 44 · 2013: 45 · 2012: 40
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-65611, R01HL065611)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- mucin, mucus, sputum, mucociliary clearance, innate immunity, mucin glycosylation, secreted mucins, mucin secretion, chronic inflammatory airway diseases, asthma, chronic bronchitis, cystic fibrosis, airway obstruction, proteoglycans
- MeSH terms
- Asthma, Cystic Fibrosis, Female, Humans, Male, Mucins, Mucociliary Clearance, Mucus, Respiratory System, Sensitivity and Specificity, Sputum, Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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