Aging, Diabetes, and Hypertension Are Associated With Decreased Nasal Mucociliary Clearance
Abstract
Background We showed previously that nasal mucociliary clearance was decreased in critically ill elderly subjects, most of whom had diabetes mellitus (DM) and/or hypertension (HTN). To determine if these changes were due to the effects of aging, disease, or critical illness, we studied nasal mucociliary clearance and mucus properties in an ambulatory population consisting of young, elderly, and healthy subjects and those with DM, HTN, or both.Methods Of 440 subjects contacted, 252 entered the study. The subjects were divided into the following groups: (1) healthy (n 5 79, 18-94 years, 50 men) and (2) DM and/or HTN, of which 37 had DM (14-90 years, 12 men), 52 had HTN (23-90 years, 12 men), and 84 had both DM and HTN (25-82 years, 33 men). Subjects were also grouped by age: , 40 years, 40 to 59 years, and 60 years. We assessed demographic and clinical data, quality of life using the 36-Item Short Form Health Survey (SF-36) questionnaire, nasal mucociliary clearance using the saccharine transit test (STT), and in vitro mucus properties by examining the sneeze (high airflow) clearability and contact angle. A logistic regression analysis for prolonged STT . 12 min was used, and we controlled for age, sex, and diseases.Results Subjects aged . 60 years reported a decreased SF-36 physical component relative to other age groups. Sex, BMI, BP, heart rate, pulse oximetry, blood glucose level, and mucus properties were not associated with prolonged STT. Aging and DM and/or HTN independently increased the risk of prolonged STT.Conclusions Aging and DM, HTN, or both diseases are independently associated with decreased nasal mucociliary clearance. This may predispose toward respiratory infections.
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In healthy aging, a decrease in mucociliary clearance can be conducive to microbial invasion in the lower airways and alveoli.
“In healthy aging, a decrease in mucociliary clearance can be conducive to microbial invasion in the lower airways and alveoli (63–65).”
From Aging and Lung Disease (2020) · cites this paper as [64]
COPD is associated with abnormalities in ciliary function and decreased mucociliary clearance, which can lead to increased incidence of recurrent infections, bronchiectasis, and airway obstruction.
“COPD is also associated with abnormalities in ciliary function and decreased mucociliary clearance, which can lead to increased incidence of recurrent infections, bronchiectasis, and airway obstruction (19, 63, 64, 86, 140).”
From Aging and Lung Disease (2020) · cites this paper as [64]
Depressed clearance mechanisms, such as cough, oral and mucociliary clearance, and swallowing disorders, can increase susceptibility to pneumonia.
“Also, depressed clearance mechanisms, such as cough, oral and mucociliary clearance, and swallowing disorders can also increase susceptibility (40, 63, 64, 140).”
From Aging and Lung Disease (2020) · cites this paper as [64]
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- Authors
- Proença de Oliveira-Maul, J., Barbosa de Carvalho, H., Goto, D. M., Maia, R. M., Fló, C., Barnabé, V., Franco, D. R., Benabou, S., Perracini, M. R., Jacob-Filho, W., Saldiva, P. H. N., Lorenzi-Filho, G., Rubin, B. K., & Nakagawa, N. K.
- Affiliations
- Universidade de São Paulo (BR)
- Virginia Commonwealth University (US)
- Corresponding author
- Nakagawa, Naomi Kondo
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 143
- Issue
- 4
- Pages
- 1091-1097
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2065530559
- Cited by
- 93
- References
- 50
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 2 · 2014: 4 · 2013: 4
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (07/51605-9)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- nasal mucociliary clearance, aging, diabetes mellitus, hypertension, contact angle, quality of life, respiratory infections, older adults
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Diabetes Mellitus, Female, Health Surveys, Humans, Hypertension, Male, Middle Aged, Mucociliary Clearance, Nasal Mucosa, Quality of Life, Surveys and Questionnaires, Comorbidity, Logistic Models, Young Adult
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