Histological Behavior of Hepatic Steatosis in Morbidly Obese Patients after Weight Loss Induced by Bariatric Surgery
Open accessAbstract
Background Hepatic steatosis has a high prevalence among morbidly obese patients. Its relation to steatohepatitis and cirrhosis has been extensively studied among these patients. The aim of this study was to evaluate the behavior of hepatic steatosis with weight loss 1 year after bariatric surgery. Methods This study is a historical cohort that compared liver biopsies obtained from morbidly obese patients during the bariatric operation, with percutaneous biopsies taken from the same patient 1 year after surgery. The results were compared with weight loss, patients' profile (gender, age, body mass index (BMI) and waist/hip ratio), and with the presence of co-morbidities such as diabetes, hypertension, and dyslipidemia. Results 90 patients who had liver biopsies taken at the operation and postoperative period for bariatric surgery were included. The prevalence of hepatic steatosis was 87.6%. The average percent of excess weight loss was 81.4%. On the second biopsy, 16 patients (17.8%) of the total had the same degree of steatosis, 25 (27.8%) improved their steatosis pattern and 49 (54.4%) had normal hepatic tissue. There was no statistical difference regarding age, BMI, waist/hip ratio, and co-morbidities (P>0.05), but there was a difference in gender (P=0.044). Conclusion Significant improvement in the hepatic histology of steatosis was observed after weight loss induced by bariatric surgery in most patients. There was no patient with a worsening in the histology.
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Mottin et al. reported that bariatric surgery-induced weight loss led to marked improvement or resolution of hepatic steatosis in morbidly obese patients within the first postoperative year.
“Histological evaluation by Mottin et al. reported that bariatric surgery-induced weight loss led to marked improvement or resolution of hepatic steatosis in morbidly obese patients, evident within the first postoperative year [32].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [32]
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Moran, M. W., Ramírez, E. P., Zook, J. D., Saarinen, A. M., Baravati, B., Goode, M. R., Laloudakis, V., Kaschner, E. K., Olson, T., Craciunescu, F. M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249164 · Cited by 2
Non-Alcoholic Fatty Liver Disease
Weiß, J., Rau, M., & Geier, A. (2014) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2014.0447 · Cited by 155 · see citing works
Júnior, F., & Kiyoshi, C. (2006) · doi:10.11606/d.5.2006.tde-31102006-142922 · Cited by 2 · see citing works
Esteatosis hepática y resistencia a la insulina: ¿qué ocurre primero?
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The Liver in Type 2 Diabetes Mellitus
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“Similarly, although obesity clearly increases exposure to fat-derived inflammatory mediators, some morbidly obese individuals have normal livers at the time of gastric bypass surgery ( 36 ).”
BackgroundNon-alcoholic Fatty Liver Disease and Surgery
Ahmed, M. (2019) · Liver Disease and Surgery [Working Title] · doi:10.5772/intechopen.86146 · Cited by 1 · see citing works
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“Recent studies revealed some improvements in steatosis, inflammation, and liver fibrosis after bariatric surgery, but its efficiency for fatty liver and metabolic disorders was not proven so far (16-24).”
BackgroundReichert, M., Strowitzki, M. J., Tuffs, C., Amati, A., Amin, D., Raj, S., Sprenger, T., Hecker, A., & Schneider, M. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2927-4771
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Käkelä, P., Rantanen, T., Paajanen, H., & Virtanen, K. (2021) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjab247
“to significant reductions in the mean levels of ALT, grade of steatosis, hepatic inflammation, fibrosis and mortality [8].”
BackgroundNon-alcoholic steatohepatitis (NASH) and metabolic surgery in Asia
Raj, P., Bhattacharya, S., Kumar, S. S., Sabnis, S., Parthasarathi, R., Swamy, P. D. K., & Palanivelu, C. (2017) · doi:10.21037/4114
“Multiple studies which have reported improvement after gastric bypass (46-51).”
BackgroundNon-Alcoholic Fatty Liver Disease
Tan, H.-H., & Chang, J. (2010) · Proceedings of Singapore Healthcare · doi:10.1177/201010581001900106
Micro-nutritional, Endocrine, and Metabolic Complications in Bariatric Surgery-Case Capsules
Mishra, S., & Raj, P. (2021) · Springer eBooks · doi:10.1007/978-981-33-4702-1_23
Non-alcoholic Fatty Liver Disease and the Effects of Bariatric Surgery
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Nonalcoholic Fatty Liver Disease
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- Authors
- Mottin, C. C., Moretto, M., Padoin, A. V., Kupski, C., Swarowsky, A. M., Glock, L., Duval, V., & da Silva, J. B.
- Affiliations
- Hospital São Lucas da PUCRS (BR)
- Venue
- Obesity Surgery
- Published
- 2005-06
- Volume
- 15
- Issue
- 6
- Pages
- 788-793
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2134297499
- Cited by
- 97
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- hepatic steatosis, bariatric surgery
- MeSH terms
- Adult, Fatty Liver, Female, Humans, Intraoperative Period, Liver, Male, Obesity, Morbid, Postoperative Period, Gastric Bypass, Weight Loss
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