Bariatric Surgery in NAFLD
Abstract
Currently, there are no approved medications to treat patients with nonalcoholic steatohepatitis (NASH) with fibrosis or cirrhosis. Although the management goal in these patients is weight reduction by 7-10% with lifestyle modifications, only less than 10% of patients achieve this target at 1-year, and fewer maintain the weight loss at 5 years. Bariatric surgery is an option that may be considered in those who fail to lose weight by lifestyle changes. Bariatric surgery has been shown to improve liver histology including fibrosis secondary to NASH, in addition to other benefits including an improvement or resolution of type 2 diabetes mellitus, dyslipidemia, and hypertension, and a reduction of cardiovascular morbidity or mortality. There are no guidelines of bariatric surgery indications for the management of NASH. The purpose of this review is to critically appraise the current knowledge of the role of bariatric surgery and the potential mechanisms for its perceived benefits in the management of patients with NASH-related liver disease.
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Studies have shown that while NASH resolution was achieved in the majority of patients after bariatric surgery, a considerable number were still found with histologically advanced fibrosis despite NASH resolution.
“Also, studies have shown that while NASH resolution was achieved in the majority of patients, a considerable number were still found with histologically advanced fibrosis despite NASH resolution [69].”
From Current treatment of non‐alcoholic fatty liver disease (2022) · cites this paper as [69]
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Current treatment of non‐alcoholic fatty liver disease
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- Authors
- Chauhan, M., Singh, K., & Thuluvath, P. J.
- ORCID
- Thuluvath, Paul J.
- Venue
- Digestive Diseases and Sciences
- Published
- 2022-01-04
- Volume
- 67
- Issue
- 2
- Pages
- 408-422
- ISSN
- 0163-2116
- 1573-2568
- Cited by
- 42
- References
- 18
- Language
- en
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