The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity
Abstract
Adrenal cortical secretion of glucocorticoids is an essential adaptive response of an organism to stress. Although the hypothalamic-pituitary-adrenal axis regulates the adrenal cortex via release of ACTH, there is strong evidence supporting a role for sympathetic innervation in modulating adrenal glucocorticoid secretion. The dissociation between changes in ACTH and glucocorticoids under non-stress and stress conditions has reinforced the concept that neural control of the adrenal cortex acts to modulate steroidogenic responses to circulating ACTH. A dual control of the adrenal cortex has been implicated in the prominent circadian rhythm in glucocorticoids. However, the central neural substrate for circadian changes in glucocorticoids that are mediated by peripheral neural innervation of the adrenal cortex has not been conclusively delineated. The hypothesis to be addressed is that neurons in the paraventricular nucleus of the hypothalamus receive input from the suprachiasmatic nucleus and project to sympathetic preganglionic neurons in the spinal cord to provide inhibitory and excitatory input to the adrenal cortex that drives the circadian rhythm. This review examines anatomical and physiological evidence that forms the basis for this putative neural circuit.
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“The SCN shows, indeed, direct and indirect projections (mainly via the subparaventricular zone and the dorsomedial nucleus of the hypothalamus) to the PVN [17, 18].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [18]
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Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
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Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
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Post-Traumatic Stress Disorder
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Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188
A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications
Godoy, L. D., Rossignoli, M. T., Delfino-Pereira, P., Garcia‐Cairasco, N., & Umeoka, E. H. D. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00127 · Cited by 991
Circadian Rhythms: Mechanisms and Therapeutic Implications
Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645
The cortisol awakening response: More than a measure of HPA axis function
Clow, A., Hucklebridge, F., Stalder, T., Evans, P., & Thorn, L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.011 · Cited by 635
Metadata
- Authors
- Engeland, W. C., & Arnhold, M. M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Engeland, William C.
- ORCID
- Engeland, William C.
- Venue
- Endocrine
- Published
- 2005
- Volume
- 28
- Issue
- 3
- Pages
- 325-332
- ISSN
- 0969-711X (ISSN-L)
- OpenAlex
- W1991558113
- Cited by
- 178
- References
- 103
- Citations by year
- 2026: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 18 · 2013: 14 · 2012: 17
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institute on Drug Abuse (T32-DA-07097, T32DA007097)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- circadian rhythm, glucocorticoid secretion, hypothalamic-pituitary-adrenal axis, ACTH, paraventricular nucleus, suprachiasmatic nucleus, neural circuits, stress response, steroidogenesis
- MeSH terms
- Adrenal Cortex, Animals, Autonomic Fibers, Preganglionic, Circadian Rhythm, Corticosterone, Humans, Paraventricular Hypothalamic Nucleus, Periodicity, Suprachiasmatic Nucleus, Sympathetic Nervous System
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