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The Relationship between Amyloid and Tau
Abstract
Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.
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The Centiloid Project provides guidance to convert SUVr information from different amyloid PET ligands into a common 100-point scale.
“this prompted the Centiloid Project, which has provided guidance on how to convert SUVr information from different amyloid PET ligands into a common, 100-point scale 116 .”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [116]
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Metadata
- Authors
- Hardy, J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Hardy, John
- ORCID
- Hardy, John
- Venue
- Journal of Molecular Neuroscience
- Published
- 2003
- Volume
- 20
- Issue
- 2
- Pages
- 203-206
- ISSN
- 0895-8696 (ISSN-L)
- OpenAlex
- W1982459660
- Cited by
- 80
- References
- 19
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, tau protein, APP gene, Alzheimer's disease pathogenesis, neurofibrillary tangles, Lewy bodies, synuclein, cell death pathways, genetic lesions
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Brain, Humans, Models, Neurological, Nerve Tissue Proteins, Neurons, Neurofibrillary Tangles, tau Proteins, Synucleins
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