The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Placental nutrient supply and fetal growth
Open accessAbstract
This review considers mechanisms by which transfer across the placenta takes place and how the capacity of the placenta to supply nutrients relates to fetal growth and vice versa. Blood flow through both uterine and umbilical circulations of the placenta, the structural properties of the placental exchange barrier and its related diffusional permeability, and the expression and activity of a wide range of transporter proteins in the syncytiotrophoblast, the transporting epithelium of the placenta, all need to be taken into account in considering placental supply capacity. We discuss the evidence that each of these factors affects, and is affected by, fetal growth rate and consider the regulatory mechanisms involved, with a particular focus on data that has emerged from study of the system A amino acid transporter. We consider that future work will build on the considerable foundation of knowledge regarding placental transfer mechanisms, as well as the other aspects of placental structure and function, to develop new diagnostic and therapeutic strategies for pregnancy complications, such as fetal growth restriction or overgrowth.
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Citations
Cites
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Self-citationCnossen, J. S., Morris, R. K., ter Riet, G., Mol, B. W. J., van der Post, J. A. M., Coomarasamy, A., Zwinderman, A. H., Robson, S. C., Bindels, P. J. E., Kleijnen, J., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070430 · Cited by 719
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
Dobson, P. D., & Kell, D. B. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2438 · Cited by 475 · cited 1×
“Diffusional permeability of the placenta to hydrophilic molecules Hydrophilic molecules have poor solubility in lipid bilayers and therefore do not easily cross plasma membranes (Dobson and Kell, 2008).”
BackgroundClinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery
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“These changes in placental system A activity in P0 knockout mice were specifically associated with changes in Slc38a4 expression (Constancia et al., 2005).”
BackgroundSelf-citationThe influence of the intrauterine environment on human placental development
Burton, G. J., Jauniaux, E., & Charnock-Jones, D. S. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082764gb · Cited by 307
Diabetes and Obesity in the Offspring of Pima Indian Women With Diabetes During Pregnancy
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Diabetes Alters the Expression and Activity of the Human Placental GLUT1 Glucose Transporter1
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Increase in normal placental weights related to increase in maternal body mass index
Swanson, L. D., Bewtra, C., Swanson, L. D., & Bewtra, C. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701866963 · Cited by 52
Cited by
Maltepe, E., & Fisher, S. J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125620 · Cited by 592
Placental Adaptation: What Can We Learn from Birthweight:Placental Weight Ratio?
Hayward, C. E., Lean, S., Sibley, C. P., Jones, R. L., Wareing, M., Greenwood, S. L., & Dilworth, M. R. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00028 · Cited by 286
Self-citationPlacental structure, function and drug transfer
Griffiths, S. K., & Campbell, J. P. (2015) · Continuing Education in Anaesthesia Critical Care & Pain · doi:10.1093/bjaceaccp/mku013 · Cited by 272
Oskvig, D. B., Elkahloun, A. G., Johnson, K. R., Phillips, T. M., & Herkenham, M. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.015 · Cited by 248
“The developing fetus relies on placental transfer of maternal nutrients including oxygen and glucose across the transporting epithelial membrane into the fetal capillary circulation (Desforges and Sibley, 2009).”
Humans at high altitude: Hypoxia and fetal growth
Moore, L. G., Charles, S. M., & Julian, C. G. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.04.017 · Cited by 251
Metadata
- Authors
- Desforges, M., & Sibley, C. P.
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 2010
- Volume
- 54
- Issue
- 2-3
- Pages
- 377-390
- ISSN
- 0214-6282 (ISSN-L)
- OpenAlex
- W2033408373
- Cited by
- 184
- References
- 10
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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