Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

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Items 401–500 of 744

1. Intestinal injury in paracetamol overdose (ATOM‐8)
   Varan Perananthan, Fathima Shihana, Angela Lin Chiew, Jacob George, Andrew Hamilton Dawson, Nicholas Allan Buckley · 2023 · Journal of Gastroenterology and Hepatology
2. Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol
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3. Drug Induced Liver Injury: Mechanisms, Diagnosis, and Clinical Management
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4. Implementation and outcome of an electronic tool for detection of paracetamol overdose in a tertiary care hospital
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5. Jekyll and Hyde: Nuclear receptors ignite and extinguish hepatic oxidative milieu
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6. Synthesis, characteristic fragmentation patterns, and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen
   Joseph Tsemeugne, Pamela Kemda Nangmo, Pierre Mkounga, Jean‐De‐Dieu Tamokou, Iréne Chinda Kengne, Giles Edwards, Emmanuel Sopbué Fondjo, Augustin Ephrem Nkengfack · 2021 · Heterocyclic Communications
7. Acetaminophen syn. Paracetamol: Acute Liver Injury and Acute on Chronic Liver Failure with Case Analysis and Causality Assessment Using RUCAM
   Rolf Teschke · 2020 · Springer eBooks
8. Feasibility of TSPO-Specific Positron Emission Tomography Radiotracer for Evaluating Paracetamol-Induced Liver Injury
   Daehee Kim, Byung Seok Moon, Sun Mi Park, Sang Ju Lee, Seo Young Kang, Sanghui Park, Seung Jun Oh, Bom Sahn Kim, Hai‐Jeon Yoon · 2021 · Diagnostics
9. Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis
   Marta Moreno‐Torres, Alfonso Quintás‐Cardama, Teresa Martínez-Sena, Ramiro Jover, José Vicente Castell · 2024 · International Journal of Molecular Sciences
10. UPLC-QTOF-MS based targeted metabolomics to unravel the hepatoprotective marker compounds of Swertia chirayita
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11. Synthesis and physiological effects of new 4-aminophenol derivatives as paracetamol analogues
    Maryna Lisouskaya, Olga A. Antipova, Irina P. Zhavoronok, Alexander Mikhalchuk · 2024 · Bioorganic & Medicinal Chemistry Letters
12. Study on the toxicity and in vitro and in vivo antidiabetic activities of Miliusa velutina stem bark ethanolic extract
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13. Morin: a promising nutraceutical therapy for modulation of the NF-kB/NOX-2/IL-6/HO-1 signaling pathways in paracetamol-induced liver toxicity
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14. Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures
    Omid Mehrpour, Christopher O. Hoyte, Samaneh Nakhaee, Bruno Mégarbane, Foster R. Goss · 2023 · BMC Medical Informatics and Decision Making
15. Serum microRNA‑122 for assessment of acute liver injury in patients with extensive skeletal muscle damage
    Yu Zhang, Chui Mei Ong, Kara L. Lynch, Javier C. Waksman, Alan H.B. Wu · 2024 · Laboratory Medicine
16. Delayed treatment with hydro-ethanolic extract of Khaya grandifoliola protects mice from acetaminophen-hepatotoxicity through inhibition of c-Jun N-terminal kinase phosphorylation and mitochondrial dysfunction
    Arnaud Fondjo Kouam, Ibrahim Njingou, Nina Magoudjou, Hamed Bechir Ngoumbe, Philipe Herman Nfombouot Njitoyap, Elisabeth Menkem Zeuko'o, Frédéric Nico Njayou, Paul Fewou Moundipa · 2024 · Pharmaceutical Science Advances
17. PPARβ/δ agonist GW0742 mitigates acute liver damage induced by acetaminophen overdose in mice
    Lin Wang, Jing-Hui Chen, Yan-Jing Zhang, Ming-Bao Zhang, Tao Zeng · 2024 · Toxicology and Applied Pharmacology
18. Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics
    Joe Jongpyo Lim, Curtis D. Klaassen, Julia Yue Cui · 2024 · Drug Metabolism and Disposition
19. Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an in vitro model for assessing population variability in hepatotoxicity testing
    Xiugong Gao, Rong Li, Kayla Campasino, Miranda R. Yourick, Yang Zhao, Robert L. Sprando, Jeffrey J. Yourick · 2025 · Current Research in Toxicology
20. Traditional Chinese Medicine Yang-Gan-Wan Alleviated Experimental Hepatic Damage by Inhibiting Oxidation, Inflammation, and Apoptosis in Cell and Mouse Models
    Chia-Wen Yeh, Wan‐Jhen Wu, Chen‐Wen Lu, Sheue‐Er Wang, Wu‐Chang Chuang, Ming-Chung Lee, Chung‐Hsin Wu · 2021 · Evidence-based Complementary and Alternative Medicine
21. Aqueous Extract of Erythrina senegalensis Exhibits Dose-Dependent Hepatoprotective Activity on Paracetamol-Induced Liver Damage in Wistar Rats
    Patience Chwe Igeh, Elkanah Ishaku, Nangbes Jacob Gungsat, Solomon Samuel Choji, Francis Obiora Okonkwo · 2022 · Advances in Biological Chemistry
22. Isolated paracetamol-induced acute kidney injury: a systematic review
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23. Association between adverse outcomes of hepatitis A and acetaminophen use: A population-based cohort study
    Gi Chan Park, Jung Wha Chung, Eun Sun Jang, Jin‐Wook Kim · 2023 · Digestive and Liver Disease
24. Assessment of Anti-Hepatotoxic Effect of Bahuinia tomentosa Linn against Paracetamol induced Hepatocellular Damage In Albino Mice
    Jeslyne M. Jeyaraj, Senthilnathan Balaraman, Vigneshwar Murugesan, Balaji Pandiyan, S. Umakrithika, Anitha Kandhasamy · 2023 · Research Journal of Pharmacy and Technology
25. In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes
    Alicia Rosell-Hidalgo, Christopher Bruhn, Emma Shardlow, Ryan W. Barton, Stephanie Ryder, Timur R. Samatov, Alexandra Hackmann, Gerald Ryan Aquino, M. Fernandes dos Reis, Vladimir Galatenko et al. · 2023 · Expert Opinion on Drug Metabolism & Toxicology
26. Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment
    Steven J. Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water · 2024 · ALTEX
27. A real-world disproportionality analysis of baloxavir marboxil: post-marketing pharmacovigilance data
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28. Acidose à la 5-oxoproline induite par le paracétamol : une cause rare d’acidose métabolique à trou anionique augmenté
    Antoine Lanot, Patrick Henri, Marie Nowoczyn, M.H. Read, Christophe Maucorps, Marion Sassier, Thierry Lobbedez · 2017 · La Revue de Médecine Interne
29. Drug and herbal/dietary supplements-induced liver injury: A tertiary care center experience
    Ayesha Siddique, Osama Siddique, Michael M. Einstein, Eva Urtasun Sotil, Saverio Ligato · 2020 · World Journal of Hepatology
30. Hydrastis canadensis (Goldenseal) and Other Berberine-Containing Botanicals
    Roy Upton · 2020 · Elsevier eBooks
31. Evaluating the Psychiatric Benefits of Formulating Acetaminophen With N-Acetylcysteine
    Ryan Serdenes, James Graham · 2020 · Frontiers in Psychiatry
32. Electronic-prescribing tools improve N-acetylcysteine prescription accuracy and timeliness for patients who present following a paracetamol overdose: A digital innovation quality-improvement project
    Adam McCulloch, Asif Sarwar, Tom Bate, Dave Thompson, Patrick McDowell, Qamar Sharif, Elizabeth Sapey, Adam Seccombe · 2020 · Digital Health
33. Electrocortical Effects of Acetaminophen during Emotional Picture Viewing, Cognitive Control, and Negative Feedback
    Katie E. Garrison, Julia B Mcdonald, A. Crowell, Nicholas J. Kelley, B. Schmeichel · 2021 · Cognitive, Affective, & Behavioral Neuroscience
34. Mechanism of dasabuvir inhibition of acetaminophen glucuronidation
    Qingchen Zhang, Su Xiang Duan, Jerold S. Harmatz, Zixuan Wei, Christopher A. Singleton, David J. Greenblatt · 2021 · Journal of Pharmacy and Pharmacology
35. Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end
    Tamara Sanhueza-Aroca, Samuel Verdugo-Silva, Erwin Olate-Fica, Luisa Rivas, Claudio Müller-Ramírez · 2021 · Nepal Journal of Epidemiology
36. Study the hepatoprotective effects and oxidant-antioxidant status of beta vulgaris roots ethanolic extract in hepatotoxic rats induced by acetaminophen
    Shams Kareem Mahmood, Salma Jameel Askar · 2022 · International Journal of Health Sciences
37. Sulfhemoglobinemia and methemoglobinemia following acetaminophen overdose
    Justin A. Seltzer, Irvan J. Bubic, Garret A. Winkler, Nathan A. Friedman, Jessica Bagby, Christian Tomaszewski, Richard F. Clark, Allyson A. Kreshak, Daniel R. Lasoff · 2022 · Toxicology Reports
38. HISTOPATHOLOGICAL STRUCTURE OF WHITE RATS LIVER AFTER GIVING ANT NEST EXTRACT DUE TO INDUCED PARACETAMOL TOXIC DOSE
    I Made Merdana, I Made Kardena, Ketut Budiasa, I Made Dodi Gunawan · 2019 · Buletin Veteriner Udayana
39. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease
    Seiichi Ishida · 2019 · Elsevier eBooks
40. The Conceptual Framework of Anglo-Scottish Union
    John Robertson · 2009 · Hedatuz - Repositorio Digital de Euskomedia
41. Drugs Used in Rheumatic Disease
    Ivan Padjen · 2018 · Technical report
42. Focus on pharmacogenomics, phytonutrient-drug interactions and COVID-19 vaccines: Perspectives on ADRs, ADEs, and SEDs
    Sidhartha D. Ray, Jasmine A. Luzum, Joshua P. Gray, SIDNEY J. STOHS · 2021 · Side effects of drugs annual
43. Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury
    Elissa Everton, Mercedes del Río-Moreno, Carlos Villacorta-Martín, Pushpinder Bawa, Jonathan Lindstrom-Vautrin, Hiromi Muramatsu, Fatima Rizvi, Anna R. Smith, Ying K. Tam, Norbert Pardi et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
44. Evaluation of the Acute Toxicity of Acetaminophen in Mice
    Suhad H Hashem, Falah Muosa Kadhim Al-Rekabi, Selman Ali · 2023 · The Iraqi Journal of Veterinary Medicine
45. Enzyme kinetic and in silico characterization of cytochrome P450 2E1 inhibition by hydro-ethanolic extract of Entada africana and its protective role in acetaminophen-induced hepatotoxicity
    Arnaud Fondjo Kouam, Cromwel Tepap Zemnou, Eléonore Ngounou, Felicité Syntia Douanla Somene, Elisabeth Zeuko’o Menkem, Elvis Amih Ofon, Frédéric Nico Njayou, Paul Fewou Moundipa · 2025 · Journal of Ethnopharmacology
46. Insights into the Biochemical and Immune Mechanisms in Drug-Induced Liver Injury Pathogenesis
    Eleanor Saville, Georgia Wells, Liam Farrell, Dean John Naisbitt, Xiaoli Meng · 2026 · Chemical Research in Toxicology
47. Fermented Syzygium samarangense leaves mitigate oxidative stress-triggered hepatotoxicity through Nrf2 activation and epigenetic regulation
    Ssu-Han Huang, Zi-Han Lin, Tien‐Yuan Wu, Guor-Jien Wei, Yen‐Chen Tung, Zheng‐Yuan Su · 2023 · Food Bioscience
48. Improving Postoperative Pediatric Recovery by Efficient Recovery Room Care—A Comprehensive Review
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49. Pharmacist-Driven Chondroprotection in Osteoarthritis: A Multifaceted Approach Using Patient Education, Information Visualization, and Lifestyle Integration
    Eloy del Río · 2025 · Pharmacy
50. Acetaminophen-induced fulminant liver failure (clinical case presentation and a review of the literature)
    Leonid Klimov, A. G. Aksenov, E. V. Popova, Погорелова Лариса Витальевна, Р О Цуцаев, Yu. V. Bykov, В. С. Кашников, Dmitry Bobryshev, Victoriya A. Kuryaninova, Marina Stoyan et al. · 2018 · Meditsinskiy sovet = Medical Council
51. Optimizing Acetaminophen Use in Patients with Risk Factors for Hepatotoxicity: Reviewing Dosing Recommendations in Adults
    Deanna K. Bauerlein, Allison P. Williams, Preeti R. John · 2020 · Pain Medicine
52. Evaluation of the protective effect of curcumin on encephalopathy caused by intrahepatic and extrahepatic damage in male rats.
    Forouzan Frozandeh, Nader Shahrokhi, Mohammad Khaksari, Sedigheh Amiresmaili, Gholamreza Asadikaram, Nava Shahrokhi, Maryam Iranpour · 2021 · Europe PMC (PubMed Central)
53. Macrophage migration inhibitory factor as a potential biomarker in acetaminophen overdose: a pilot study
    Joshua Bloom, Teddy O. Uzamere, Yasmin L. Hurd, Alex F. Manini · 2022 · Toxicology Communications
54. Fructose as a novel nutraceutical for acetaminophen (APAP)-induced hepatotoxicity
    Kyle Rodrigues, Rawdat Hussain, Sarah Cooke, Gary Zhang, Deqiang Zhang, Lei Yin, Xin Tong · 2023 · Metabolism and Target Organ Damage
55. Synthesis, spectroscopic analysis, quantum chemical calculations and in silico biological activity studies of a new series of 8-aryl xanthine
    Mustafa Tuğfan Bilkan, Hamsa Abdullah Najeeb, Ayşe Halıç Poslu, Çiğdem Bilkan, Gamze Koz · 2024 · Journal of Molecular Structure
56. Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region
    Hernan A. Bazán, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey St Pierre, Neehar N Desai, Philip J. Daly, Jessica A. Cucinello‐Ragland et al. · 2024 · Scientific Reports
57. Three consecutive cases of acute liver failure in young women due to acetaminophen overdose: insights into Japanese social issues and transplantation landscape
    Kotaro Doi, Jun Inoue, Masashi Ninomiya, Akitoshi Sano, Mio Tsuruoka, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Atsushi Masamune · 2024 · Clinical Journal of Gastroenterology
58. Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts—Ischemic Hepatitis vs Acetaminophen Overdose
    Jody A. Rule, Faith Ajayi, Laura Phillips James, Shannan R. Tujios, Norman Sussman, Jorge L. Rakela, Daniel R. Ganger, N BASS, Adrian Reuben, R. Todd Stravitz et al. · 2024 · Digestive Diseases and Sciences
59. Paracetamol Poisoning: Epidemiology, Diagnosis, Treatment (Status of the Issue)
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60. Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review
    Ali Mobasheri, Bart J. Morlion, Vidhu Sood Sethi, Mary Suma Cardosa, Oscar E. Della Pasqua, Pranab Kalita · 2025 · British Journal of Clinical Pharmacology
61. Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice
    Olamide B. Adelusi, Caitlin Schneider, Caylie McKimens, James P. Luyendyk, Anup Ramachandran, Hartmut Jaeschke · 2025 · Archives of Toxicology
62. Adverse Events and Over-the-Counter (OTC) Drugs: Is Inappropriate Labeling the Problem? - The Case of Acetaminophen
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63. Acetaminophen and Acetylsalicylic Acid Exposure in a Preterm Infant after Maternal Overdose
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64. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats
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65. Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations
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67. Probiotics: past, present, and future challenges
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68. Acute Liver Failure
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69. Dibenzocyclooctyne linked lysine-cyclodextrin for efficient intranucleus delivery of proteins
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70. Hepatoprotective Properties of Cuminum cyminum Seeds Powder as Post-Treatment for Acetaminophen-Induced Injury
    Afsaneh Mozaffarinia, Ali Gol, Aghileh Mohammadzadeh · 2023 · Journal of Advances in Medical and Biomedical Research
71. Development and Evaluation of Stable Paracetamol Loaded Solid Dispersion with Enhanced Analgesic and Hepatoprotective Property
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72. Investigating the hepatoprotective properties of thymol against paracetamol-induced hepatotoxicity
    Md Tarikul Islam, Saikot Mazumder, Fariha Tabassum Aniqa, Nizam Uddin, Mohammad Asikur Rahman, Chandan Kumar Sarkar, Milon Mondal, Mohammad Suleiman Mubarak, Kannan R. R. Rengasamy · 2024 · Food Bioscience
73. Ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry‐characterized extract of Aerides odorata Lour alleviates paracetamol‐induced hepatotoxicity in animal model evidenced by biochemical, molecular, and computational studies
    A. M. Abu Ahmed, Md. Atiar Rahman, Farjana Sharmen, A.S.M. Ali Reza, Md. Shahidul Islam, Md. Mamunur Rashid, Md. Khalid Juhani Rafi, Tanvir Ahmed Siddique, Md. Muzahid Ahmed Ezaj, Srabonti Saha et al. · 2024 · Animal Models and Experimental Medicine
74. Protective Effect of Ethanolic Extract of Saussurea Lappa on Paracetamol Induced Toxicity in Female Rabbits
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75. Massive Acetaminophen Overdose
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76. Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration
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77. Potential benefits of using hydrogen sulfide, vitamin E and necrostatin-1 to counteract acetaminophen‑induced hepatotoxicity in rats
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78. Proteomic and microbial assessments on the effect of Antrodia cinnamomea in C57BL/6 mice
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79. Gut Microbiota Mediates the Therapeutic Effect of Monoclonal Anti-TLR4 Antibody on Acetaminophen-Induced Acute Liver Injury in Mice
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80. Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats
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81. Synergistic Hepatoprotective Interaction between α-Tocopherol and Ascorbic Acid on Paracetamol Induced Liver Damage in Rats
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83. A high-throughput microphysiological system to quantify key events leading to liver fibrosis
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84. Crotalaria assamica Benth alleviated acetaminophen-induced liver injury through the upregulation of Nrf2 pathway
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85. Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity
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86. Retracted and Republished from: “Gut Microbiota Mediates the Therapeutic Effect of Monoclonal Anti-TLR4 Antibody on Acetaminophen-Induced Acute Liver Injury in Mice”
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87. Two versus Three Infusion Regimens of N-Acetylcysteine for Acetaminophen Overdose
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88. Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction
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89. Therapeutic liver cell transplantation to treat murine PKU
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90. Piperine as an Herbal Alternative for the Prevention of Drug-Induced Liver Damage Caused by Paracetamol
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91. A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
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92. Cytochrome P450 enzymes activity in rat liver under conditions of toxic injury and partial hepatectomy
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93. Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system
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94. Ameliorative Effect of Nutmeg (Myristica fragrans) Supplement against Acetaminophen - Induced Hepato-Renal Toxicity in Wistar Rats
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95. Paracetamol toxicity in mild overdose in combination with opioids: A retrospective observational study
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96. Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal
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98. Effects of coenzyme Q10 and N-acetylcysteine on experimental poisoning by paracetamol in Wistar rats
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100. Application of TSPO-Specific Positron Emission Tomography Radiotracer as an Early Indicator of Acute Liver Failure Induced by Propacetamol, a Prodrug of Paracetamol
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