Cited by 744Drug-Induced Hepatotoxicity and ProtectionPoisoning and overdose treatmentsLiver Disease Diagnosis and Treatment

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Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

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Eric D. Yoon, Arooj Babar, Moaz Maqbool Choudhary, Matthew Kutner, Nikolaos Pyrsopoulos·2016·Journal of Clinical and Translational Hepatology

DOI 10.14218/jcth.2015.00052PMC PMC4913076

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Abstract

Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. APAP hepatotoxicity remains a global issue; in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases. The pathophysiology, disease course and management of acute liver failure secondary to APAP toxicity remain to be precisely elucidated, and adverse patient outcomes with increased morbidity and mortality continue to occur. Although APAP hepatotoxicity follows a predictable timeline of hepatic failure, its clinical presentation might vary. N-acetylcysteine (NAC) therapy is considered as the mainstay therapy, but liver transplantation might represent a life-saving procedure for selected patients. Future research focus in this field may benefit from shifting towards obtaining antidotal knowledge at the molecular level, with focus on the underlying molecular signaling pathways.

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Fig. 1. Acetaminophen (APAP) metabolic pathway.CC BY-NC · PubMed Central

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Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 972
Untitled work
(2018) · doi:10.1001/jama · Cited by 932
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
McGill, M. R., Sharpe, M. R., Williams, C. D., Taha, M., Curry, S. C., & Jaeschke, H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59755 · Cited by 764
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
McGill, M. R., & Jaeschke, H. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1007-6 · Cited by 703
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Prescott, L. F., Illingworth, R. N., Critchley, J. A., Stewart, M. J., Adam, R. D., & Proudfoot, A. T. (1979) · BMJ · doi:10.1136/bmj.2.6198.1097 · Cited by 667
Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily
Watkins, P. B., Kaplowitz, N., Slattery, J. T., Colonese, C. R., Colucci, S. V., Stewart, P. W., & Harris, S. (2006) · JAMA · doi:10.1001/jama.296.1.87 · Cited by 631
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Prescott, L. F., Illingworth, R. N., Critchley, J., & Proudfoot, A. T. (1980) · BMJ · doi:10.1136/bmj.280.6206.46-b · Cited by 625
Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure
Harrison, P. M., Wendon, J. A., Gimson, A. E. S., Alexander, G. J. M., & Williams, R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106273242604 · Cited by 585
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
Jaeschke, H., Williams, C. D., Ramachandran, A., & Bajt, M. L. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02501.x · Cited by 478

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N -(3-Chloro-4-hydroxyphenyl)acetamide
Uppu, R. M., & Fronczek, F. R. (2025) · IUCrData · doi:10.1107/s2414314625006959 · Cited by 1
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Authors: Yoon, E. D., Babar, A., Choudhary, M. M., Kutner, M., & Pyrsopoulos, N.
Affiliations: University Hospital, Newark (US)
ORCID: Moaz Maqbool Choudhary
Nikolaos Pyrsopoulos
Venue: Journal of Clinical and Translational Hepatology
Publisher: Xia & He Publishing
Published: 2016-06-17
Volume: 4
Issue: 2
Pages: 131-42
ISSN: 2225-0719 (ISSN-L)
2310-8819
DOI: 10.14218/jcth.2015.00052
PMC: PMC4913076
OpenAlex: W2461975652
Cited by: 744
References: 78
Citations by year: 2026: 25 · 2025: 62 · 2024: 97 · 2023: 92 · 2022: 96 · 2021: 90 · 2020: 86 · 2019: 78 · 2018: 68 · 2017: 40 · 2016: 8
FWCI: 11.42
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
Locations: Journal of Clinical and Translational Hepatology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: acetaminophen hepatotoxicity, acetaminophen overdose, acute liver failure, liver transplantation, molecular pathways, antidotes

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