Effects of HIV-1 gp120 and tat on endothelial cell sensescence and senescence-associated microRNAs
Open accessAbstract
The aim of this study was to determine, in vitro, the effects of X4 and R5 HIV-1 gp120 and Tat on: (1) endothelial cell senescence and (2) endothelial cell microRNA (miR) expression. Endothelial cells were treated with media without and with: R5 gp120 (100 ng/mL), X4 gp120 (100 ng/mL), or Tat (500 ng/mL) for 24 h and stained for senescence-associated β-galactosidase (SA-β-gal). Cell expression of miR-34a, miR-217, and miR-146a was determined by RT-PCR. X4 and R5 gp120 and Tat significantly increased (~100%) cellular senescence versus control. X4 gp120 significantly increased cell expression of miR-34a (1.60 ± 0.04 fold) and miR-217 (1.52 ± 0.18), but not miR-146a (1.25 ± 0.32). R5 gp120 significantly increased miR-34a (1.23 ± 0.07) and decreased miR-146a (0.56 ± 0.07). Tat significantly increased miR-34a (1.49 ± 0.16) and decreased miR-146a (0.55 ± 0.23). R5 and Tat had no effect on miR-217 (1.05 ± 0.13 and 1.06 ± 0.24; respectively). HIV-1 gp120 (X4 and R5) and Tat promote endothelial cell senescence and dysregulation of senescence-associated miRs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HIV proteins gp120 and Tat can induce senescence in aortic endothelial cells.
“The HIV virus may also independently contribute to cardiovascular risk as HIV proteins gp120 and Tat can induce senescence in aortic endothelial cells (Hijmans et al, 2018).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Hijmans et al, 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 3× · see citing works
“These and other senescence-associated cytokines can induce senescence in bystander endothelial cells and stimulate monocyte activation and infiltration through the vascular wall, promoting atherosclerotic lesion development (Acosta et al. 2013).”
BackgroundMicroRNA biogenesis: coordinated cropping and dicing
Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1644 · Cited by 2,019 · see citing works
Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J., & Toussaint, O. (2009) · Nature Protocols · doi:10.1038/nprot.2009.191 · Cited by 1,668 · see citing works
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 986 · see citing works
Regulation of SIRT1 in cellular functions: Role of polyphenols
Chung, S., Yao, H., Caito, S. W., Hwang, J., Arunachalam, G., & Rahman, I. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.003 · Cited by 651 · see citing works
Vascular Cell Senescence: Contribution to Atherosclerosis
Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542 · see citing works
Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500 · see citing works
MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1
Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., Vasa‐Nicotera, M., Ippoliti, A., Novelli, G., Melino, G., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.864629 · Cited by 479 · see citing works
Arterial Inflammation in Patients With HIV
Subramanian, S. S., Tawakol, A. A., Burdo, T. H., Abbara, S., Wei, J., Vijayakumar, J., Corsini, E. M., Abdelbaky, A., Zanni, M. V., Hoffmann, U., et al. (2012) · JAMA · doi:10.1001/jama.2012.6698 · Cited by 463 · see citing works
Islam, F., Wu, J., Jansson, J., & Wilson, D. (2012) · HIV Medicine · doi:10.1111/j.1468-1293.2012.00996.x · Cited by 432 · see citing works
Chemokine Receptors in Human Endothelial Cells
Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E. H., & Stadel, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4282 · Cited by 408 · see citing works
Vascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399 · see citing works
Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli
Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 355 · see citing works
MicroRNA-34a regulation of endothelial senescence
Ito, T., Yagi, S., & Yamakuchi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.012 · Cited by 336 · see citing works
Zhao, T., Li, J., & Chen, A. F. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00192.2010 · Cited by 325 · see citing works
eNOS Activity Is Reduced in Senescent Human Endothelial Cells
Matsushita, H., Chang, E., Glassford, A. J., Cooke, J. P., Chiu, C., & Tsao, P. S. (2001) · Circulation Research · doi:10.1161/hh2101.098443 · Cited by 302 · see citing works
VASILE, E., TOMITA, Y., BROWN, L. F., KOCHER, O., & DVORAK, H. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0051com · Cited by 232 · see citing works
Identification of HIV-1 Envelope Glycoprotein in the Serum of AIDS and ARC Patients
Oh, S. K., Cruikshank, W. W., Raina, J., Blanchard, G. C., Adler, W. H., Walker, J. E., & Kornfeld, H. (1992) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-199203000-00005 · Cited by 229 · see citing works
MitomiRs in human inflamm-aging: A hypothesis involving miR-181a, miR-34a and miR-146a
Rippo, M. R., Olivieri, F., Monsurrò, V., Prattichizzo, F., Albertini, M. C., & Procopio, A. D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.002 · Cited by 209 · see citing works
Chemokine receptor CCR5: from AIDS to atherosclerosis
Jones, K. L., Maguire, J. J., & Davenport, A. P. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01147.x · Cited by 185 · see citing works
miR-146a is modulated in human endothelial cell with aging
Vasa‐Nicotera, M., Chen, H., Tucci, P., Yang, A. L., Saintigny, G., Menghini, R., Mahé, C., Agostini, M., Knight, R. A., Melino, G., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.034 · Cited by 184 · see citing works
Krouwer, V. J. D., Hekking, L. H. P., Langelaar‐Makkinje, M., Regan‐Klapisz, E., & Post, J. A. (2012) · Vascular Cell · doi:10.1186/2045-824x-4-12 · Cited by 160 · see citing works
Emerging roles of SIRT1 in vascular endothelial homeostasis
Potente, M., & Dimmeler, S. (2008) · Cell Cycle · doi:10.4161/cc.7.14.6267 · Cited by 158 · see citing works
Role of microRNAs in endothelial cell pathophysiology
Staszel, T., Zapała, B., Polus, A., Sadakierska−Chudy, A., Kieć‐Wilk, B., Stępień, E. Ł., Wybrańska, I., Chojnacka, M., & Dembinska-Kiec, A. (2011) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1093 · Cited by 151 · see citing works
HIV Proteins and Endothelial Dysfunction: Implications in Cardiovascular Disease
Anand, A. R., Rachel, G., & Parthasarathy, D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00185 · Cited by 142 · see citing works
Badi, I., Burba, I., Ruggeri, C., Zeni, F., Bertolotti, M., Scopece, A., Pompilio, G., & Raucci, A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu180 · Cited by 134 · see citing works
Sato, I., Morita, I., Kaji, K., Ikeda, M.-A., Nagao, M., & Murota, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2153 · Cited by 128 · see citing works
MicroRegulators come of age in senescence
Gorospe, M., & Abdelmohsen, K. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.03.005 · Cited by 108 · see citing works
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
Ullrich, C., Groopman, J. E., & Ganju, R. K. (2000) · Blood · doi:10.1182/blood.v96.4.1438 · Cited by 104 · see citing works
HIV-1 Tat protein and endothelium: From protein/cell interaction to AIDS-associated pathologies
Rusnati, M., & Presta, M. (2002) · Angiogenesis · doi:10.1023/a:1023892223074 · Cited by 104 · see citing works
Comparison of early passage, senescent and hTERT immortalized endothelial cells
Chang, M. W.-F., Grillari, J., Mayrhofer, C., Fortschegger, K., Allmaier, G. M., Marzban, G., Katinger, H. W. D., & Voglauer, R. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.05.002 · Cited by 99 · see citing works
Kline, E. R., & Sutliff, R. L. (2008) · Journal of Investigative Medicine · doi:10.1097/jim.0b013e3181788d15 · Cited by 93 · see citing works
Role of microRNAs in endothelial inflammation and senescence
Qin, B., Yang, H., & Xiao, B. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1241-0 · Cited by 91 · see citing works
Shaker, O. G., Maher, M., Nassar, Y., Morcos, G. N. B., & GAD, Z. A. (2015) · Gene · doi:10.1016/j.gene.2015.01.062 · Cited by 87 · see citing works
Murphy, M. S. Q., Casselman, R., Tayade, C., & Smith, G. N. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.05.013 · Cited by 83 · see citing works
Duan, M., Yao, H., Hu, G., Chen, X., Lund, A. K., & Buch, S. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060170 · Cited by 77 · see citing works
Ye, X., Hemida, M. G., Qiu, Y., Hanson, P., Zhang, H. M., & Yang, D. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1411-4 · Cited by 71 · see citing works
Wang, T., Yi, R., Green, L. A., Chelvanambi, S., Seimetz, M., & Clauss, M. A. (2015) · Cardiovascular Pathology · doi:10.1016/j.carpath.2015.07.001 · Cited by 69 · see citing works
Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
Prattichizzo, F., Giuliani, A., Nigris, V. D., Pujadas, G., Çeka, A., Sala, L. L., Genovese, S., Testa, R., Procopio, A. D., Olivieri, F., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12688 · Cited by 69 · see citing works
Li, H., Wang, X., Cheng, J., You, S.-Z., Ma, S.-H., Zhong, X., Quan, L., & Luo, B. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.03.009 · Cited by 61 · see citing works
Jiang, J., Fu, W., Wang, X., Lin, P. H., Yao, Q. C., & Chen, C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq013 · Cited by 51 · see citing works
MicroRNAs in Endothelial Senescence and Atherosclerosis
Menghini, R., Casagrande, V., & Federici, M. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9487-7 · Cited by 46 · see citing works
Hijmans, J. G., Stockelman, K., Garcia, V. P., Levy, M. V., Brewster, L., Bammert, T. D., Greiner, J. J., Stauffer, B. L., Connick, E., & DeSouza, C. A. (2019) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.118.011134 · Cited by 35 · see citing works
Self-citationHIV-related mechanisms in atherosclerosis and cardiovascular diseases
Gibellini, D., Borderi, M., Clò, A., Morini, S., Miserocchi, A., Bon, I., Ponti, C., & Re, M. C. (2013) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3283619331 · Cited by 33 · see citing works
HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs
Cohen, J., D’Agostino, L., Tüzer, F., & Torres, C. A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.008 · Cited by 31 · see citing works
miR-34a is a common link in both HIV- and antiretroviral therapy-induced vascular aging
Zhan, J., Qin, S., Lu, L., Hu, X., Zhou, J., Sun, Y., Yang, J., Liu, Y., Wang, Z., Tan, N., et al. (2016) · Aging · doi:10.18632/aging.101118 · Cited by 30 · see citing works
Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function
Hijmans, J. G., Stockelman, K. A., Levy, M. V., Brewster, L. M., Bammert, T. D., Greiner, J. J., Connick, E., & DeSouza, C. A. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01048.2018 · Cited by 25 · see citing works
Self-citationHaser, G. C., & Sumpio, B. E. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.01.036 · Cited by 20 · see citing works
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
Ullrich, C., Groopman, J. E., & Ganju, R. K. (2000) · Blood · doi:10.1182/blood.v96.4.1438.h8001438_1438_1442 · Cited by 11 · see citing works
MacEneaney, O. J., Connick, E., & DeSouza, C. A. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181fb1cb3 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
HIV Proteins and Endothelial Dysfunction: Implications in Cardiovascular Disease
Anand, A. R., Rachel, G., & Parthasarathy, D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00185 · Cited by 142 · see citing works
MicroRNA-34a: the bad guy in age-related vascular diseases
Raucci, A., Macrì, F., Castiglione, S., Badi, I., Vinci, M. C., & Zuccolo, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03979-4 · Cited by 114 · see citing works
Cardiovascular Disease and Thrombosis in HIV Infection
Perkins, M. V., Joseph, S., Dittmer, D. P., & Mackman, N. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318232 · Cited by 98 · see citing works
Cerebral Vascular Toxicity of Antiretroviral Therapy
Bertrand, L., Velichkovska, M., & Toborek, M. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09858-x · Cited by 80 · see citing works
Hijmans, J. G., Stockelman, K., Garcia, V. P., Levy, M. V., Brewster, L., Bammert, T. D., Greiner, J. J., Stauffer, B. L., Connick, E., & DeSouza, C. A. (2019) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.118.011134 · Cited by 35 · see citing works
Self-citationThe struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
The Interaction of Viruses with the Cellular Senescence Response
Seoane, R., Vidal, S., Bouzaher, Y. H., El Motiam, A., & Rivas, C. (2020) · Biology · doi:10.3390/biology9120455 · Cited by 49 · see citing works
Marino, J., Wigdahl, B. L., & Nonnemacher, M. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00168 · Cited by 43 · see citing works
Gorwood, J., Ejlalmanesh, T., Bourgeois, C., Mantecon, M., Rose, C., Atlan, M., Desjardins, D., Grand, R. L., Fève, B., Lambotte, O., et al. (2020) · Cells · doi:10.3390/cells9040854 · Cited by 38 · see citing works
Platelets in HIV: A Guardian of Host Defence or Transient Reservoir of the Virus?
Pretorius, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649465 · Cited by 32 · see citing works
HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs
Cohen, J., D’Agostino, L., Tüzer, F., & Torres, C. A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.008 · Cited by 31 · see citing works
HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps
Prakash, P., Vetha, B. S. S., Chakraborty, R., Wenegieme, T., Masenga, S. K., Muthian, G., Balasubramaniam, M., Wanjalla, C. N., Hinton, A. O., Jr., Kirabo, A., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.323979 · Cited by 27 · see citing works
Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function
Hijmans, J. G., Stockelman, K. A., Levy, M. V., Brewster, L. M., Bammert, T. D., Greiner, J. J., Connick, E., & DeSouza, C. A. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01048.2018 · Cited by 25 · see citing works
Self-citationHIV Infection, Antiretroviral Drugs, and the Vascular Endothelium
Kanmogne, G. D. (2024) · Cells · doi:10.3390/cells13080672 · Cited by 24 · see citing works
Chen, Y., Stampley, J., Irving, B. A., & Dugas, T. R. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz203 · Cited by 22 · see citing works
Impact of human immunodeficiency virus on pulmonary vascular disease
Kumar, A., Mahajan, A., Salazar, E. A., Pruitt, K., Guzman, C. A., Clauss, M. A., Almodóvar, S., & Dhillon, N. K. (2021) · Global Cardiology Science and Practice · doi:10.21542/gcsp.2021.12 · Cited by 18 · see citing works
The impacts of chronic infections on shaping cellular senescence
Johnson, A., Rought, T., Aronov, J., Pokharel, P., Chiu, A., & Nasuhidehnavi, A. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00533-9 · Cited by 12 · see citing works
Sivasankar, C., Adler, M., Chen, L., Kaur, S., & Dhillon, N. K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1621338 · Cited by 10 · see citing works
HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells
Casanova, V., Rodríguez-Agustín, A., Ayala-Suárez, R., Moraga, E., Maleno, M. J., Mallolas, J., Martínez, E., Sánchez‐Palomino, S., Miró, J. M., Alcamı́, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1568762 · Cited by 10 · see citing works
Role of Brain Arterial Remodeling in HIV-Associated Cerebrovascular Outcomes
Spagnolo‐Allende, A., & Gutierrez, J. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.593605 · Cited by 9 · see citing works
Brewster, L. M., Coombs, G. B., Garcia, V. P., Hijmans, J. G., DeSouza, N. M., Stockelman, K. A., Barak, O. F., Mijačika, T., Dujić, Ž., Greiner, J. J., et al. (2020) · Clinical Science · doi:10.1042/cs20200047 · Cited by 9 · see citing works
Self-citationMiR-34a and endothelial biology
Li, Q., & Zhang, Q. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121976 · Cited by 8 · see citing works
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities
Kaur, G., Rahman, M. S., Shaikh, S. B., Panda, K., Chinnapaiyan, S., Estevez, M. S., Xia, L., Unwalla, H. J., & Rahman, I. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116179 · Cited by 6 · see citing works
Kerferd, J., Limaye, S., & Gnanenthiran, S. R. (2025) · Internal Medicine Journal · doi:10.1111/imj.70223 · Cited by 3 · see citing works
TLR7 Mediates HIV ‐1 Tat‐Induced Cellular Senescence in Human Astrocytes
Rezagholizadeh, N., Datta, G., Hasler, W. A., Nguon, E. C., Smokey, E. V., & Chen, X. (2025) · Aging Cell · doi:10.1111/acel.70086 · Cited by 3 · see citing works
Li, Z., Chen, Z., Liu, C., Peng, S., & Wang, N. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04743-3 · Cited by 2 · see citing works
HIV-associated preeclampsia: evaluation of lymphangiogenesis in placental bed samples
Onyangunga, O. A., Naidoo, P., Moodley, J., & Naicker, T. (2025) · Histochemistry and Cell Biology · doi:10.1007/s00418-025-02359-4
From Envelope to Encephalopathy: How HIV-1 gp120 Drives Neurocognitive Decline
Santerre, M., Shrestha, J., Allen, C. N. S., Shcherbik, N., & Sawaya, B. (2026) · Viruses · doi:10.3390/v18050495
- Authors
- Hijmans, J. G., Stockleman, K., Reiakvam, W., Levy, M. V., Brewster, L. M., Bammert, T. D., Greiner, J. J., Connick, E., & DeSouza, C. A.
- Affiliations
- University of Colorado Boulder (US)
- University of Arizona (US)
- Corresponding author
- DeSouza, Christopher A.
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 6
- Issue
- 6
- Pages
- e13647
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC5875545
- OpenAlex
- W2796369912
- Cited by
- 31
- References
- 54
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UA Campus Repository (The University of Arizona) (acceptedVersion, cc-by)
- Funders
- National Institutes of Health (HL131458)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- HIV-1, gp120, Tat, endothelial cell senescence, miR-34a, miR-146a, miR-217, R5-tropic HIV-1, X4 HIV-1, senescence-associated β-galactosidase, endothelial dysfunction
- MeSH terms
- Cardiovascular Diseases, Cells, Cultured, Humans, HIV Infections, HIV Envelope Protein gp120, Cellular Senescence, MicroRNAs, Endothelial Cells, tat Gene Products, Human Immunodeficiency Virus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
