MicroRNA biogenesis: coordinated cropping and dicing
Abstract
The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.
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miRNAs are 19-24 nucleotide noncoding RNAs that act as important regulators of posttranscriptional gene expression.
“MicroRNAs (miRNAs) are 19-to 24-nucleotide (nt) noncoding RNAs that act as important regulators of posttranscriptional gene expression (Ambros, 2004;Kim, 2005).”
From Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes (2013) · cites this paper as Kim, 2005
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- Authors
- Kim, V. N.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2005-05-01
- Volume
- 6
- Issue
- 5
- Pages
- 376-385
- ISSN
- 1471-0072
- 1471-0080
- Cited by
- 2,019
- References
- 4
- Language
- en
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