The space-flight environment: the international space station and beyond
Open accessAbstract
Human space exploration is dependent on robust spacecraft design and sophisticated life-support technologies, both of which are critical for working in the hostile space environment. This article focuses on the specific challenges of the space environment. In an upcoming issue, a Dispatch from Space
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On ISS, modafinil is available to the crew to optimize performance while fatigued.
“On ISS, modafinil is available to the crew to optimize performance while fatigued [34].”
From Sleep disruption, use of sleep-promoting medication and circadian desynchronization in spaceflight crewmembers: Evidence in low-Earth orbit and concerns for future deep-space exploration missions (2023) · cites this paper as [34]
The Circadian dyssynchrony section discusses disrupted sleep aboard the ISS, but does not mention modafinil or medication for fatigued crew. Searches for “modafinil” and fatigue-related performance found no passage establishing that modafinil is available to the crew. (LLM, conf=0.76)
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Cites
Space Radiation and Cataracts in Astronauts
Cucinotta, F. A., Manuel, F. K., Jones, J., Iszard, G., Murrey, J., Djojonegro, B., & Wear, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0460:sracia]2.0.co;2 · Cited by 391 · see citing works
Radiation protection guidance for activities in low-earth orbit
Townsend, L. W., & Fry, R. J. (2002) · Advances in Space Research · doi:10.1016/s0273-1177(02)00160-6 · Cited by 295 · see citing works
Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights
Dijk, D.-J., Neri, D. F., Wyatt, J. K., Ronda, J. M., Riel, E., Ritz-De Cecco, A., Hughes, R. J., Elliott, A. R., Prisk, G. K., West, J. B., et al. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1647 · Cited by 268 · see citing works
Spaceflight Life Support and Biospherics
Eckart, P. (1996) · Springer eBooks · doi:10.1007/978-94-017-3038-9 · Cited by 260 · see citing works
Guidance on Radiation Received in Space Activities
LUSHBAUGH, C. C. (1990) · Radiation Research · doi:10.2307/3577786 · Cited by 244 · see citing works
Natural and Induced Environment in Low Earth Orbit
Wilson, J. W., Badavi, F. F., Kim, M. Y., Clowdsley, M. S., Heinbockel, J. H., Cucinotta, F. A., Badhwar, G. D., Atwell, W., & Huston, S. L. (2002) · Cited by 31 · see citing works
Life in extreme environments: how will humans perform on Mars?
Newman, D. J. (2000) · PubMed · Cited by 31 · see citing works
International space station acoustics
Goodman, J. R. (2000) · The Journal of the Acoustical Society of America · doi:10.1121/1.4743126 · Cited by 20 · see citing works
Microgravity Environment on the International Space Station
DeLombard, R., Hrovat, K., Kelly, E., et al. (2004) · AIAA Aerospace Sciences Meeting and Exhibit · doi:10.2514/6.2004-125 · Cited by 12 · see citing works
The space environment and its impact on spacecraft design
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Orbital Debris: Past, Present, and Future
Stansbery, G., & Johnson, N. A. (2013) · NASA Technical Reports Server (NASA) · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
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- Koontz S, Suggs R, Schneider T, et al. Progress in spacecraft environment inter- actions: International Space Station development and operations. Proceedings of 26 th Annual International Space Development Conference. 2007 May 25-28; Dallas (TX).
- Soares C, Mikatarian R, Schmidl R, et al. Natural and induced space environments effects on the International Space Station. Proceedings of the 56th International Astronautical Congress; 2005 Oct. 17-21; Fukuoka, Japan. IAC-05-B4.2.07
Cited by
Sorted by citations
Acclimation during space flight: effects on human physiology
Williams, D., Kuipers, A., Mukai, C., & Thirsk, R. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.090628 · Cited by 378 · see citing works
Self-citationCarillo, P., Morrone, B., Fusco, G. M., De Pascale, S., & Rouphael, Y. (2020) · Agronomy · doi:10.3390/agronomy10050687 · Cited by 74 · see citing works
Oxidative Stress and Space Biology: An Organ-Based Approach
Goodwin, T., & Christofidou-Solomidou, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040959 · Cited by 53 · see citing works
Petit, G., Cebolla, A. M., Fattinger, S., Petieau, M., Summerer, L., Cheron, G., & Huber, R. (2019) · npj Microgravity · doi:10.1038/s41526-019-0069-0 · Cited by 52 · see citing works
‘A review of algal research in space’.
Niederwieser, T., Kociolek, P., & Klaus, D. (2018) · Acta Astronautica · doi:10.1016/j.actaastro.2018.03.026 · Cited by 52 · see citing works
Albornoz-Miranda, M., Parrao, D., & Taverne, M. (2023) · Sleep Medicine: X · doi:10.1016/j.sleepx.2023.100080 · Cited by 14 · see citing works
“On ISS, modafinil is available to the crew to optimize performance while fatigued [34].”
Background
- Authors
- Thirsk, R., Kuipers, A., Mukai, C., & Williams, D.
- Affiliations
- Canadian Space Agency (CA)
- Japan Aerospace Exploration Agency (JP)
- ORCID
- Thirsk, R.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Impact Inc.
- Published
- 2009-06-01
- Volume
- 180
- Issue
- 12
- Pages
- 1216-1220
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- PMC
- PMC2691437
- OpenAlex
- W2162755716
- Cited by
- 231
- References
- 11
- Citations by year
- 2026: 21 · 2025: 41 · 2024: 30 · 2023: 21 · 2022: 31 · 2021: 21 · 2020: 17 · 2019: 11 · 2018: 19 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Medical Association Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Space Agency
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space exploration and regulation
- Keywords
- space environment, International Space Station, human spaceflight, spacecraft design, life support systems, radiation exposure
- MeSH terms
- Humans, Light, Radiation, Ionizing, Space Flight, Temperature, Vacuum, Occupational Health, Extravehicular Activity, Astronauts
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