Oxidative Stress and Space Biology: An Organ-Based Approach
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The environment of space provides many challenges to the human physiology and therefore to extended habitation and exploration[...]
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Changes in ROS seem to be involved in the pathogenesis of bone loss because radiation damages skeletal lipids and the activity of the antioxidant enzyme NRF2 in bone tissue.
“Changes in ROS seem to be involved in the pathogenesis of bone loss because radiation damages skeletal lipids and the activity of the antioxidant enzyme NRF2 in bone tissue86.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [86]
Section 3 (page unavailable) links ROS to bone resorption and reports bone loss after high-dose radiation in mice, supporting a possible role for ROS in bone loss. It does not report radiation damage to skeletal lipids or NRF2 activity in bone tissue: Section 2 discusses lipid peroxidation generally, while Section 3 locates radiation-related NRF2 suppression in mouse liver. (LLM, conf=0.88)
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- Authors
- Goodwin, T., & Christofidou-Solomidou, M.
- Affiliations
- National Aeronautics and Space Administration (US)
- Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Edward J. Stemmler Hall, 2nd Floor, Office Suite 227, Philadelphia, PA 19104, USA
- Corresponding author
- Goodwin, Thomas
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-03-23
- Volume
- 19
- Issue
- 4
- Pages
- 959
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5979446
- OpenAlex
- W2794165558
- Cited by
- 53
- References
- 17
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 1 · 2018: 5
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (ES013508)
- National Institute of Environmental Health Sciences (P42ES023720, ES013508, P30ES013508)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, space biology, space exploration
- MeSH terms
- Biology, Space Flight, Weightlessness, Oxidative Stress
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