Staging model raises fundamental questions about the nature of bipolar disorder
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The concept of clinical staging is commonly applied in the management of various medical conditions, including cancer, hypertension, kidney disease or diabetes. In these conditions, the individual stages can be differentiated by clinical presentation and/or by specific biological markers, and they
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So far, the heterogeneity intrinsic to BD has prevented the clinical use of staging systems.
“So far, the heterogeneity intrinsic to BD has prevented the clinical use of staging systems.32”
From Canadian Network for Mood and Anxiety Treatments ( <scp>CANMAT</scp> ) and International Society for Bipolar Disorders ( <scp>ISBD</scp> ) 2018 guidelines for the management of patients with bipolar disorder (2018) · cites this paper as [32]
The ‘Staging and heterogeneity in bipolar disorder’ section describes heterogeneity as a challenge to interpreting apparent stages. ‘Testing the hypothesis’ concludes that the staging concept is not yet ready for clinical application, but cites unresolved testing, clinical differentiation and medication effects as well. The paper does not say that heterogeneity alone has prevented clinical use. (LLM, conf=0.86)
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Shrivastava, A., Sousa, A. D., Datta, M., Mishra, A., Gupt, M., & Dalal, P. (2025) · Open Journal of Psychiatry · doi:10.4236/ojpsych.2025.154026 · Cited by 1 · see citing works
- Authors
- Alda, M., & Kapczinski, F.
- Affiliations
- Dalhousie University (CA)
- From the Department of Psychiatry, Dalhousie University, Halifax, NS (Alda); and the Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil (Kapczinski)
- ORCID
- Alda, Martin
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2016-09
- Volume
- 41
- Issue
- 5
- Pages
- 291-293
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC5008917
- OpenAlex
- W2511292496
- Cited by
- 13
- References
- 24
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dalhousie University
- Universidade Federal do Rio Grande do Sul
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, clinical staging, disease staging, biomarkers, disease classification, clinical features
- MeSH terms
- Bipolar Disorder, Humans, Models, Biological, Severity of Illness Index
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