Cited by 217Bipolar Disorder and TreatmentPersonality Disorders and PsychopathologySchizophrenia research and treatment

Staging systems in bipolar disorder: an I nternational S ociety for B ipolar D isorders T ask F orce R eport

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Kapczinski, F., Magalhães, P. V. S., Balanzá‐Martinez, V., Dias, V. V., Frangou, S., Gama, C. S., Gonzalez‐Pinto, A., Grande, I. +15 more·2014·Acta Psychiatrica Scandinavica

Abstract

Objective: We discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined. Method: We reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging. Results: We report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and the potential utility of neurocognitive, neuroimaging and peripheral biomarkers. Conclusion: Most studies to date indicate that globally defined late‐stage patients have a worse overall prognosis and poorer response to standard treatment, consistent with patterns for end‐stage medical disorders. We believe it is possible at this juncture to speak broadly of ‘early’‐ and ‘late’‐stage bipolar disorder. Next steps require further collaborative efforts to consider the details of preillness onset and intermediary stages, and how many additional stages are optimal.

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Crossref · 10.1111/acps.12305

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Authors
Kapczinski, F., Magalhães, P. V. S., Balanzá‐Martinez, V., Dias, V. V., Frangou, S., Gama, C. S., Gonzalez‐Pinto, A., Grande, I., Ha, K., Kauer‐Sant'Anna, M., Kunz, M., Kupka, R., Leboyer, M., Lopez‐Jaramillo, C., Post, R. M., Rybakowski, J. K., Scott, J., Strejilevitch, S., Tohen, M., Vazquez, G., Yatham, L., Vieta, E., & Berk, M.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • National Institute for Translational Medicine Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil
  • Section of Psychiatry Department of Medicine University of Valencia‐CIBERSAM and Hospital Universitari Doctor Peset Valencia Spain
  • University of Lisbon (PT)
  • King's College London (GB)
  • Hospital Universitario de Alava (Santiago) University of the Basque Country CIBERSAM Vitoria Spain
  • Centro de Investigación Biomédica en Red de Salud Mental (ES)
  • Seoul National University (KR)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Université Paris-Est Créteil (FR)
  • Department of Psychiatry Mood Disorders Program School of Medicine University of Antioquia Medellin Colombia
  • Bipolar Collaborative Network Bethesda MD USA
  • Poznan University of Medical Sciences (PL)
  • Newcastle University (GB)
  • Bipolar Disorder Program Neurosciences Institute Favaloro University Buenos Aires Argentina
  • University of New Mexico (US)
  • Department of Neurosciences University of Palermo Buenos Aires Argentina
  • University of British Columbia (CA)
  • Barwon Health (AU)
Corresponding author
Kapczinski, F.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2014-06-25
Volume
130
Issue
5
Pages
354-363
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W2124464277
Cited by
217
References
85
Citations by year
2026: 13 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 24 · 2018: 23 · 2017: 23 · 2016: 22 · 2015: 29 · 2014: 7
FWCI
3.71
Type
journal article
Language
en
Open access
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Deakin Research Online (Deakin University) (submittedVersion)
  • Figshare (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar disorder, disease staging, prognosis, treatment response, neuroimaging biomarkers, peripheral biomarkers, first-episode bipolar disorder
MeSH terms
Bipolar Disorder, Humans, Severity of Illness Index, Societies, Medical, Biomarkers, Disease Progression, Advisory Committees

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