Cited by 317Hypothalamic control of reproductive hormonesReproductive Biology and FertilityGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

GnRH Pulsatility, the Pituitary Response and Reproductive Dysfunction

Open access

TSUTSUMI, Rie, WEBSTER, Nicholas J.G.·2009·Endocrine Journal

DOI 10.1507/endocrj.k09e-185PMC PMC4307809

Open this paper in CoChat — free account Open PDF

Abstract

GnRH plays an essential role in neuroendocrine control of reproductive function. In mammals, the pattern of gonadotropin secretion includes both pulse and surge phases, which are regulated independently. The pulsatile release of GnRH and LH plays an important role in the development of sexual function and in the normal regulation of the menstrual cycle. The importance of GnRH pulsatility was established in a series of classic studies. Fertility is impaired when GnRH pulsatility is inhibited by chronic malnutrition, excessive caloric expenditure, or aging. A number of reproductive disorders in women with including hypogonadotropic hypogonadism, hypothlamic amenorrhea, hyperprolactinemia and polycystic ovary syndrome (PCOS) are also associated with disruption of the normal pulsatile GnRH secretion. Despite these findings, the molecular mechanisms of this pulsatile GnRH regulation are not well understood. Here, we review recent studies about GnRH pulsatility, signaling and transcriptional response, and its implications for disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1507/endocrj.k09e-185

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone
Belchetz, P. E., Plant, T. M., Nakai, Y., Keogh, E. J., & Knobil, E. (1978) · Science · doi:10.1126/science.100883 · Cited by 1,385
The Neuroendocrine Control of the Menstrual Cycle
Knobil, E. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-571136-4.50008-5 · Cited by 1,285
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
THE TEMPORAL RELATIONSHIP BETWEEN GONADOTROPIN RELEASING HORMONE (GnRH) AND LUTEINIZING HORMONE (LH) SECRETION IN OVARIECTOMIZED EWES1
Clarke, I. J., & Cummins, J. T. (1982) · Endocrinology · doi:10.1210/endo-111-5-1737 · Cited by 921
Determinants of Abnormal Gonadotropin Secretion in Clinically Defined Women with Polycystic Ovary Syndrome
Taylor, A. E., McCourt, B. J., Martin, K. A., Anderson, E. J., Adams, J. M., Schoenfeld, D., & Hall, J. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4105 · Cited by 544
Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice
Windle, J. J., Weiner, R. I., & Mellon, P. L. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-4-597 · Cited by 497
GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS
Conn, P. M., & Crowley, W. F. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.391 · Cited by 457
Polycystic Ovarian Syndrome: Evidence that Flutamide Restores Sensitivity of the Gonadotropin-Releasing Hormone Pulse Generator to Inhibition by Estradiol and Progesterone
Eagleson, C. A., Gingrich, M. B., Pastor, C. L., Arora, T. K., Solorzano, C. M. B., Evans, W. S., & Marshall, J. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6992 · Cited by 413

Flagged first, then by citations

Show all 51 references

1 of the 51 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

10.1210/me.16.3.419 · DOI

Sorted by citations

Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
“GnRH pulses are required for reproductive functions in both sexes, and the importance of these pulses in driving reproduction has been described in primates and humans (Tsutsumi & Webster, 2009).”
Background
Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy
Patel, S. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.04.008 · Cited by 605
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S. P., Catteau-Jonard, S., Collier, F., Baroncini, M., Dewailly, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10055 · Cited by 404
Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression
Stamatiades, G. A., & Kaiser, U. B. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.015 · Cited by 293
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system
Maggi, R., Cariboni, A. M., Marelli, M. M., Moretti, R. M., Andrè, V., Marzagalli, M., & Limonta, P. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv059 · Cited by 285
Bisphenol A: an emerging threat to female fertility
Pivonello, C., Muscogiuri, G., Nardone, A., Garifalos, F., Provvisiero, D. P., Verde, N., de Angelis, C., Conforti, A., Piscopo, M., Auriemma, R. S., et al. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0558-8 · Cited by 263
GnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice
Wang, D., Weng, Y., Zhang, Y., Wang, R., Wang, T., Zhou, J., Shen, S., Wang, H., & Wang, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141049 · Cited by 233
A review: Brief insight into Polycystic Ovarian syndrome
Bulsara, J., Patel, P. R., Soni, A., & Acharya, S. R. (2021) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2021.100085 · Cited by 201
Sperm parameters and male fertility after bariatric surgery: three case series
Sermondade, N., Massin, N., Boitrelle, F., Pfeffer, J., Eustache, F., Sifer, C., Czernichow, S., & Lévy, R. (2011) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.014 · Cited by 126
Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis
Sen, A., & Hoffmann, H. M. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110655 · Cited by 125
Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
Wu, Q., Whiddon, B. B., & Palmiter, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120501109 · Cited by 118
Psychological aspects of infertility. A systematic review
Szkodziak, F., Krzyżanowski, J., & Szkodziak, P. R. (2020) · Journal of International Medical Research · doi:10.1177/0300060520932403 · Cited by 133
An updated view of hypothalamic–vascular–pituitary unit function and plasticity
Tissier, P. L., Campos, P., Lafont, C., Romanò, N., Hodson, D. J., & Mollard, P. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.193 · Cited by 110
Impact of Increased Oxidative Stress on Cardiovascular Diseases in Women With Polycystic Ovary Syndrome
Duică, F., Dănilă, C. A., Boboc, A. E., Antoniadis, P., Condrat, C. E., Onciul, S., Suciu, N., Creţoiu, S. M., Varlas, V. N., & Crețoiu, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.614679 · Cited by 110
Hypothalamic-Ovarian axis and Adiposity Relationship in Polycystic Ovary Syndrome: Physiopathology and Therapeutic Options for the Management of Metabolic and Inflammatory Aspects
Lonardo, M. S., Cacciapuoti, N., Guida, B., Lorenzo, M. D., Chiurazzi, M., Damiano, S., & Menale, C. (2024) · Current Obesity Reports · doi:10.1007/s13679-023-00531-2 · Cited by 125
Role of Oxidative Stress in Obese and Nonobese PCOS Patients
Uçkan, K., Demir, H., Turan, K., Sarıkaya, E., & Demir, C. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/4579831 · Cited by 97
Misunderstanding the Female Athlete Triad: Refuting the IOC Consensus Statement on Relative Energy Deficiency in Sport (RED-S)
Souza, M. J. D., Williams, N. I., Nattiv, A., Joy, E. A., Misra, M., Loucks, A. B., Matheson, G. O., Olmsted, M. P., Barrack, M. T., Mallinson, R. J., et al. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093958 · Cited by 105
Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences
Barabás, K., Szabó-Meleg, E., & Ábrahám, I. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020529 · Cited by 92
The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89
Hyperprolactinaemia in male infertility: Clinical case scenarios
Dabbous, Z., & Atkin, S. L. (2017) · Arab Journal of Urology · doi:10.1016/j.aju.2017.10.002 · Cited by 89
Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis
Qiu, L., Chen, M., Wang, X., Qin, X., Chen, S., Qian, Y., Liu, Z., Cao, Q., & Ying, Z. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx261 · Cited by 84
Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice
Gyengési, E., Liu, Z.-W., D’Agostino, G., Gan, G., Horváth, T. L., Gao, X., & Diano, S. (2010) · Endocrinology · doi:10.1210/en.2010-0681 · Cited by 86
Hypoestrogenism in young women and its influence on bone mass density
Męczekalski, B., Podfigurna-Stopa, A., & Genazzani, A. R. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.486452 · Cited by 82
Encoding and decoding mechanisms of pulsatile hormone secretion
Walker, J. J., Terry, J. R., Tsaneva‐Atanasova, K., Armstrong, S. P., McArdle, C. A., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02087.x · Cited by 78
Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS)
Phylactou, M., Clarke, S. A., Patel, B., Baggaley, C., Jayasena, C. N., Kelsey, T., Comninos, A. N., Dhillo, W. S., & Abbara, A. (2020) · Clinical Endocrinology · doi:10.1111/cen.14402 · Cited by 77
Endocrinopathies and Male Infertility
Sengupta, P., Dutta, S., Karkada, I. R., & Chinni, S. V. (2021) · Life · doi:10.3390/life12010010 · Cited by 114
Sex-derived attributes contributing to SARS-CoV-2 mortality
Chanana, N., Palmo, T., Sharma, K., Kumar, R., Graham, B. B., & Pasha, Q. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2020 · Cited by 73
Update on male reproductive endocrinology
Clavijo, R. I., & Hsiao, W. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.03.25 · Cited by 75
Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery
Tatem, A. J., Beilan, J., Kovac, J. R., & Lipshultz, L. I. (2020) · The World Journal of Men's Health · doi:10.5534/wjmh.190002 · Cited by 66
High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS
Zhang, H., Yi, M., Zhang, Y., Jin, H., Zhang, W., Yang, J., Yan, L., Li, R., Zhao, Y., & Qiao, J. (2016) · Reproduction · doi:10.1530/rep-15-0542 · Cited by 65
Exercise and Polycystic Ovary Syndrome
Woodward, A., Klonizakis, M., & Broom, D. R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_8 · Cited by 68
Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome
Deswal, R., Nanda, S., & Dang, A. S. (2019) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2019.1595217 · Cited by 62
The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats
Sandal, S., Tekin, S., Şeker, F. B., Beytur, A., Vardı, N., Çolak, C., Tapan, T. K., Yıldız, S., & Yılmaz, B. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.06.059 · Cited by 62
Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring1
Tsoulis, M. W., Chang, P. E., Moore, C. J., Chan, K. A., Gohir, W., Petrik, J., Vickers, M. H., Connor, K. L., & Sloboda, D. M. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.135004 · Cited by 61
Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling
Armstrong, S. P., Caunt, C. J., Fowkes, R. C., Tsaneva-Atanasova, K. T., & McArdle, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115964 · Cited by 58
Early-life nutritional effects on the female reproductive system
Chan, K. A., Tsoulis, M. W., & Sloboda, D. M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0469 · Cited by 58
Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling
Armstrong, S. P., Caunt, C. J., Fowkes, R. C., Tsaneva-Atanasova, K. T., & McArdle, C. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.063917 · Cited by 57
Quantitative Multianalyte Microarray Immunoassay Utilizing Upconverting Phosphor Technology
Päkkilä, H., Ylihärsilä, M., Lahtinen, S., Hattara, L., Salminen, N., Arppe, R., Lastusaari, M., Saviranta, P., & Soukka, T. (2012) · Analytical Chemistry · doi:10.1021/ac301719p · Cited by 54
Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges
Ruohonen, S. T., POUTANEN, M. H., & Tena‐Sempere, M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.06.038 · Cited by 52
Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice
Wang, H., Larson, M. A., Jablonka‐Shariff, A., Pearl, C. A., Miller, W. L., Conn, P. M., Boime, I., & Kumar, T. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321404111 · Cited by 52
Polycystic ovary syndrome: Causes, symptoms, pathophysiology, and remedies
Chaudhuri, A. (2023) · Obesity Medicine · doi:10.1016/j.obmed.2023.100480 · Cited by 55
Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome
Barbotin, A., Mimouni, N. E. H., Kuchcinski, G., Lopes, R., Viard, R., Rasika, S., Mazur, D., Silva, M. S. B., Simon, V., Boursier, A., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104535 · Cited by 53
Kisspeptin-neuron control of LH pulsatility and ovulation
Stevenson, H., Bartram, S., Charalambides, M. M., Murthy, S., Petitt, T., Pradeep, A., Vineall, O., Abaraonye, I., Lancaster, A., Koysombat, K., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951938 · Cited by 48
Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish
Ma, Y., Juntti, S. A., Hu, C. K., Huguenard, J. R., & Fernald, R. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421851112 · Cited by 47
The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome
Mahmoud, A. A., Elfiky, A. M., & Abo-Zeid, F. S. (2021) · Steroids · doi:10.1016/j.steroids.2021.108936 · Cited by 47
Assessing hypothalamic pituitary gonadal function in reproductive disorders
Koysombat, K., Dhillo, W. S., & Abbara, A. (2023) · Clinical Science · doi:10.1042/cs20220146 · Cited by 53
Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction I: Structure, Biosynthesis, Physiological Effects, and Its Role in Estrous Synchronization
Hassanein, E. M., Szelényi, Z., & Szenci, O. (2024) · Animals · doi:10.3390/ani14101473 · Cited by 45
Male Reprotoxicity and Endocrine Disruption
Campion, S. N., Catlin, N. R., Heger, N. E., McDonnell, E. V., Pacheco, S. E., Saffarini, C. M., Sandrof, M. A., & Boekelheide, K. (2012) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-7643-8340-4_11 · Cited by 49
Depression and Its Effect on the Menstrual Cycle
Padda, J., Khalid, K., Hitawala, G., Batra, N., Pokhriyal, S. C., Mohan, A., Zubair, U., Cooper, A. C., & Jean-Charles, G. (2021) · Cureus · doi:10.7759/cureus.16532 · Cited by 45
The “ram effect”: new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions
Fabre‐Nys, C., Kendrick, K. M., & Scaramuzzi, R. J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00111 · Cited by 44
Hormonal changes, semen quality and variance in reproductive activity outcomes of post pubertal rabbits fed Moringa oleifera Lam. leaf powder
Ajuogu, P. K., Mgbere, O. O., Bila, D. S., & McFarlane, J. R. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.12.036 · Cited by 44
Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C
Rizk, N. I., Rizk, M. S., Mohamed, A. S. E. D., & Naguib, Y. M. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-0563-y · Cited by 45
Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice
Luo, J., Yang, Y., Zhang, T., Su, Z., Yu, D., Lin, Q., Chen, H., Zhang, Q., Xiang, Q., Xue, W., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.021 · Cited by 42
Sleep, Circadian Rhythms, and Fertility
Goldstein, C. A., & Smith, Y. R. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0057-9 · Cited by 41
GnRH in the Human Female Reproductive Axis
Limonta, P., Marelli, M. M., Moretti, R. M., Marzagalli, M., Fontana, F., & Maggi, R. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.003 · Cited by 41
Identification of Genes Enriched in GnRH Neurons by Translating Ribosome Affinity Purification and RNAseq in Mice
Burger, L. L., Vanacker, C., Phumsatitpong, C., Wagenmaker, E. R., Wang, L., Olson, D. P., & Moenter, S. M. (2018) · Endocrinology · doi:10.1210/en.2018-00001 · Cited by 39
Emerging role of GIP and related gut hormones in fertility and PCOS
Moffett, R. C., & Naughton, V. R. (2020) · Peptides · doi:10.1016/j.peptides.2019.170233 · Cited by 41
High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats
Volk, K. M., Pogrebna, V. V., Roberts, J. A., Zachry, J. E., Blythe, S. G., & Toporikova, N. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00305 · Cited by 42
Current Trends on Bioengineering Approaches for Ovarian Microenvironment Reconstruction
Almeida, G. H. D. R., Iglesia, R. P., Rinaldi, J. D. C., Murai, M. K., Calomeno, C. V. A. Q., da Silva, L. N., Horvath-Pereira, B. D. O., Pinho, L. B. M., Miglino, M. A., & Carreira, A. C. O. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2022.0171 · Cited by 42
Metabolic treatment of syndrome linked with Parkinson's disease and hypothalamus pituitary gonadal hormones by turmeric curcumin in Bisphenol-A induced neuro-testicular dysfunction of wistar rat
Akintunde, J. K., Farouk, A., & Mogbojuri, O. M. (2018) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.12.004 · Cited by 39
Common pathophysiological mechanisms involved in luteal phase deficiency and polycystic ovary syndrome. Impact on fertility
Boutzios, G., Karalaki, M., & Zapanti, E. D. (2012) · Endocrine · doi:10.1007/s12020-012-9778-9 · Cited by 38
Management of Menorrhagia Associated with Chemotherapy‐Induced Thrombocytopenia in Women with Hematologic Malignancy
Bates, J. S., Buie, L. W., & Woodis, C. B. (2011) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.31.11.1092 · Cited by 38
Lactational Amenorrhea: Neuroendocrine Pathways Controlling Fertility and Bone Turnover
Calik-Ksepka, A., Stradczuk, M., Czarnecka, K., Grymowicz, M., & Smolarczyk, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031633 · Cited by 38
The Circadian Variation in Anti-Müllerian Hormone in Patients with Polycystic Ovary Syndrome Differs Significantly from Normally Ovulating Women
Bungum, L. J., Franssohn, F., Bungum, M., Humaidan, P., & Giwercman, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068223 · Cited by 35
Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration
Liu, S., Han, Z., Hao, J., Zhang, D., Li, X., Cao, Y., Huang, J., & Li, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.02.008 · Cited by 35
Gonadotropin-releasing hormone analogs: Mechanisms of action and clinical applications in female reproduction
Wu, H., Chang, H., & Leung, P. C. K. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100876 · Cited by 37
Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment
Constantin, S., Reynolds, D., Oh, A., Pizano, K., & Wray, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012339118 · Cited by 36
Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH
Nunemaker, C. S., & Satin, L. S. (2014) · Endocrine · doi:10.1007/s12020-014-0212-3 · Cited by 34
Influence of a Sustained Release Deslorelin Acetate Implant on Reproductive Physiology and Associated Traits in Laying Hens
Eusemann, B., Sharifi, A. R., Patt, A., Reinhard, A.-K., Schrader, L., Thöne‐Reineke, C., & Petow, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01846 · Cited by 33
Elevated baseline LH/FSH ratio is associated with poor ovulatory response but better clinical pregnancy and live birth in Chinese women with PCOS after ovulation induction
Xia, Q., Xie, L., Wu, Q., Cong, J., Ma, H., Li, J., Cai, W.-Y., & Wu, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13024 · Cited by 32
The role of GnRH in Tibetan male sheep and goat reproduction
Zhao, W., Adjei, M., Zhang, Z., Yuan, Z., Cisang, Z., & Song, T. (2023) · Reproduction in Domestic Animals · doi:10.1111/rda.14432 · Cited by 32
Effects of menopause on temperature regulation
Gombert, M., Vesterdorf, K., Fuller, A., Maloney, S. K., & Baker, F. C. (2025) · Temperature · doi:10.1080/23328940.2025.2484499 · Cited by 45
Effects of repeated administration of methylphenidate on reproductive parameters in male rats
Montagnini, B. G., Silva, L. S., dos Santos, A. H., Anselmo-Franci, J. A., Fernandes, G. S. A., Mesquita, S. D. F. P., & Gerardin, D. C. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.016 · Cited by 30
Physiological and pharmacological overview of the gonadotropin releasing hormone
Casati, L., Ciceri, S., Maggi, R., & Bottai, D. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115553 · Cited by 31
Molecular determinants of the meiotic arrests in mammalian oocytes at different stages of maturation
Öztürk, S. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2026704 · Cited by 29
Female-Specific Glucose Sensitivity of GnRH1 Neurons Leads to Sexually Dimorphic Inhibition of Reproduction in Medaka
Hasebe, M., Kanda, S., & Oka, Y. (2016) · Endocrinology · doi:10.1210/en.2016-1352 · Cited by 29
Characterisation and pharmacological analysis of a crustacean G protein-coupled receptor: the red pigment-concentrating hormone receptor of Daphnia pulex
Marco, H. G., Verlinden, H., Broeck, J. V., & GÄde, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-06805-9 · Cited by 29
Gonadotropin-Releasing Hormone (GnRH)/GnRH Receptors and Their Role in the Treatment of Endometriosis
Resta, C. A., Moustogiannis, A., Chatzinikita, E., Ntalianis, D. M., Ntalianis, K. M., Philippou, A., Koutsilieris, M., & Vlahos, N. (2023) · Cureus · doi:10.7759/cureus.38136 · Cited by 33
Exploring the endocrine-disrupting potential of atrazine for male reproduction: A systematic review and meta-analysis
Guimarães‐Ervilha, L. O., Assis, M. Q., Bento, I. P. D. S., Lopes, I. D. S., Iasbik‐Lima, T., Carvalho, R. P. R., & Machado‐Neves, M. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100989 · Cited by 28
Novel insights into the metabolic action of Kiss1 neurons
Talbi, R., & Navarro, V. M. (2020) · Endocrine Connections · doi:10.1530/ec-20-0068 · Cited by 28
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association
Ott, J., Robin, G., Hager, M., & Dewailly, D. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae030 · Cited by 27
Changes in estrone and estradiol levels during follicle development: a retrospective large-scale study
Segawa, T., Teramoto, S., Omi, K., Miyauchi, O., Watanabe, Y., & Osada, H. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0051-y · Cited by 27
Gnrh1-Induced Responses Are Indirect in Female Medaka Fsh Cells, Generated Through Cellular Networks
Hodne, K., Fontaine, R., Ager-Wick, E., & Weltzien, F. (2019) · Endocrinology · doi:10.1210/en.2019-00595 · Cited by 27
Retracted
Baby on board: Do responses to stress in the maternal brain mediate adverse pregnancy outcome?
Douglas, A. J. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.05.002 · Cited by 28
Association of LH/FSH ratio with menstrual cycle regularity and clinical features of patients with polycystic ovary syndrome
Mitrašinović‐Brulić, M., Buljan, M., & Suljević, D. (2021) · Middle East Fertility Society Journal · doi:10.1186/s43043-021-00085-0 · Cited by 32
Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer’s disease: StAR actions in prevention of neuroendocrine dysfunction
Panda, S. P., Kesharwani, A., Singh, G. D., Prasanth, D., Vatchavai, B. R., Kumari, P. V. K., Panda, S. K., & Mallick, S. P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102086 · Cited by 24
Effect of Bariatric Surgery on Semen Parameters: A Systematic Review and Meta-Analysis
Wei, Y., Chen, Q., & Qian, W. (2018) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.910862 · Cited by 24
Hypoprolactinemia and hyperprolactinemia in male schizophrenia patients treated with aripiprazole and risperidone and their relationships with testosterone levels
Tasaki, M., Yasui‐Furukori, N., Yokoyama, S., Shinozaki, M., Sugawara, N., & Shimoda, K. (2021) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12190 · Cited by 23
Hypothalamic Regulatory Mechanisms of Aging
Masliukov, P. M., & Ad, N. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021030030 · Cited by 26
Troxerutin protects against DHT-induced polycystic ovary syndrome in rats
Gao, Z., Ma, X., Liu, J., Ge, Y., Wang, L., Fu, P., Liu, Z., Yao, R., & Yan, X. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00701-z · Cited by 22
Has GnRH a direct role in AMH regulation?
van Helden, J., Evliyaoğlu, O., & Weiskirchen, R. (2019) · Clinical Endocrinology · doi:10.1111/cen.13967 · Cited by 23
Surge‐Like Luteinising Hormone Secretion Induced by Retrochiasmatic Area NK 3R Activation is Mediated Primarily by Arcuate Kisspeptin Neurones in the Ewe
Grachev, P., Porter, K. L., Coolen, L. M., McCosh, R. B., Connors, J. M., Hileman, S. M., Lehman, M. N., & Goodman, R. L. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12393 · Cited by 23
Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice
Wong, D. W., Soga, T., & Parhar, I. S. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00281 · Cited by 20
Effects of 3,4-dichloroaniline (3,4-DCA) and 4,4′-methylenedianiline (4,4′-MDA) on sex hormone regulation and reproduction of adult zebrafish (Danio rerio)
Bhuiyan, M. N. I., Kang, H., Choi, J., Lim, S., Kho, Y., & Choi, K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128768 · Cited by 20
Polymorphisms in luteinizing hormone receptor and hypothalamic gonadotropin-releasing hormone genes and their effects on sperm quality traits in Chinese Holstein bulls
Sun, L., Du, Q.-Z., Song, Y., Yu, J.-N., Wang, S., Sang, L., Song, L.-W., Yue, Y.-M., Lian, Y.-Z., Zhang, S., et al. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1543-x · Cited by 20
Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women
Liu, S., Hong, L., Lian, R., Xiao, S., Li, Y., Diao, L., & Zeng, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.874487 · Cited by 20
Autoantibodies Targeting the Hypothalamic-Pituitary-Ovarian Axis in Polycystic Ovary Syndrome: Emerging Key Players in Pathogenesis?
Akpang, N., Kwiatkowski, J., Zaborowska, Ł., & Ludwin, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094121 · Cited by 16
Mathematical modeling of endocrine regulation subject to circadian rhythm
Medvedev, A. V., Proskurnikov, A. V., & Zhusubaliyev, Z. T. (2018) · Annual Reviews in Control · doi:10.1016/j.arcontrol.2018.08.002 · Cited by 18
Apelin Receptor Signaling Protects GT1-7 GnRH Neurons Against Oxidative Stress In Vitro
Şişli, H. B., Hayal, T. B., Şenkal, S., Kıratlı, B., Sağraç, D., Seçkin, S., Özpolat, M., Şahi̇n, F., Yılmaz, B., & Doğan, A. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00968-2 · Cited by 20

Authors: TSUTSUMI, R., & WEBSTER, N. J. G.
Affiliations: University of California System (US)
Corresponding author: WEBSTER, Nicholas J.G.
ORCID: TSUTSUMI, Rie
WEBSTER, Nicholas J.G.
Venue: Endocrine Journal
Publisher: Japan Endocrine Society
Published: 2009
Volume: 56
Issue: 6
Pages: 729-737
ISSN: 0918-8959 (ISSN-L)
1348-4540
DOI: 10.1507/endocrj.k09e-185
PMC: PMC4307809
OpenAlex: W2068905180
Cited by: 317
References: 51
Citations by year: 2026: 28 · 2025: 24 · 2024: 39 · 2023: 26 · 2022: 25 · 2021: 28 · 2020: 34 · 2019: 11 · 2018: 16 · 2017: 13 · 2016: 12 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 13
FWCI: 1.41
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrine Journal (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012303, U54HD012303, R01HD047400)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: GnRH pulsatility, gonadotropin secretion, luteinizing hormone surge, gonadotrophs, reproductive disorders, hypogonadotropic hypogonadism, hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, menstrual cycle regulation, GnRH signaling, fertility
MeSH terms: Animals, Female, Humans, Infertility, Gonadotropin-Releasing Hormone, Male, Pituitary Gland, Reproduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

GnRH Pulsatility, the Pituitary Response and Reproductive Dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks