Cited by 605Ovarian function and disordersEndometriosis Research and TreatmentReproductive Biology and Fertility

Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

Patel, Seema·2018·The Journal of Steroid Biochemistry and Molecular Biology

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females. Subsequently, a huge amount of insight on PCOS has been garnered in recent times. Interventions like oral contraceptive pills, metformin, and hormone therapy have been developed to bypass or reverse the ill effects of PCOS. However, lifestyle correction to prevent aberrant immune activation and to minimize the exposure to inflammatory agents, appears to be the sustainable therapy of PCOS. This holistic review with multiple hypotheses might facilitate to devise better PCOS management approaches.

Integrity signals

Registry

Crossref · 10.1016/j.jsbmb.2018.04.008

Cites

109 of 109 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Patel, S.
Affiliations
San Diego State University (US)
Corresponding author
Patel, Seema
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2018-09
Volume
182
Pages
27-36
ISSN
0960-0760 (ISSN-L)
OpenAlex
W2801400869
Cited by
605
References
109
Citations by year
2026: 52 · 2025: 91 · 2024: 110 · 2023: 140 · 2022: 97 · 2021: 71 · 2020: 28 · 2019: 13 · 2018: 3
FWCI
4.34
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, inflammation, insulin resistance, obesity, infertility, cardiovascular risk, autoimmune disease, lifestyle modification, oral contraceptives, metformin, hormone therapy, PCOS management
MeSH terms
Endocrine System, Female, Humans, Inflammation, Insulin Resistance, Life Style, Obesity, Polycystic Ovary Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review