Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy
Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females. Subsequently, a huge amount of insight on PCOS has been garnered in recent times. Interventions like oral contraceptive pills, metformin, and hormone therapy have been developed to bypass or reverse the ill effects of PCOS. However, lifestyle correction to prevent aberrant immune activation and to minimize the exposure to inflammatory agents, appears to be the sustainable therapy of PCOS. This holistic review with multiple hypotheses might facilitate to devise better PCOS management approaches.
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He, F.-F., & Li, Y.-M. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00670-3 · Cited by 289 · see citing works
Wang, T., Sha, L., Li, Y., Zhu, L., Wang, Z., Li, K., Lu, H., Bao, T., Guo, L., Zhang, X., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00284 · Cited by 162 · see citing works
The Role of Lifestyle Interventions in PCOS Management: A Systematic Review
Gautam, R., Maan, P., Jyoti, A., Kumar, A., Malhotra, N., & Arora, T. (2025) · Nutrients · doi:10.3390/nu17020310 · Cited by 115 · see citing works
Zhang, X., Zheng, Y., Guo, Y., & Lai, Z. (2019) · International Journal of Endocrinology · doi:10.1155/2019/4386401 · Cited by 95 · see citing works
Nutritional guidelines for the management of insulin resistance
Muscogiuri, G., Barrea, L., Caprio, M., Ceriani, F., Chavez, A. O., El Ghoch, M., Frias-Toral, E., Mehta, R. J., Mendez, V., Paschou, S. A., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1908223 · Cited by 63 · see citing works
Hasan, M., Sultana, S., Sohan, M., Parvin, S., Rahman, M. A., Hossain, M. J., Rahman, M. S., & Islam, M. R. (2022) · PLOS ONE · doi:10.1371/journal.pone.0270102 · Cited by 45 · see citing works
Lin, S., Deng, Y., Huang, J., Li, M., Sooranna, S. R., Qin, M., & Tan, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-99622-4 · Cited by 35 · see citing works
Leung, W. T., Tang, Z., Feng, Y., Guan, H., Huang, Z., & Zhang, W. (2022) · Nutrients · doi:10.3390/nu14245285 · Cited by 17 · see citing works
Clarke, S., Jangid, G., Nasr, S., Atchade, A., Moody, B. L., & Narayan, G. (2023) · Cureus · doi:10.7759/cureus.45354 · Cited by 5 · see citing works
- Authors
- Patel, S.
- Affiliations
- San Diego State University (US)
- Corresponding author
- Patel, Seema
- ORCID
- Patel, Seema
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 182
- Pages
- 27-36
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2801400869
- Semantic Scholar
- 371fe886e2e4bdac08ab57410c1cda1529b9c728
- Cited by
- 605
- References
- 109
- Citations by year
- 2026: 52 · 2025: 91 · 2024: 110 · 2023: 140 · 2022: 97 · 2021: 71 · 2020: 28 · 2019: 13 · 2018: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, inflammation, insulin resistance, obesity, infertility, cardiovascular risk, autoimmune disease, lifestyle modification, oral contraceptives, metformin, hormone therapy, PCOS management
- MeSH terms
- Endocrine System, Female, Humans, Inflammation, Insulin Resistance, Life Style, Obesity, Polycystic Ovary Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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