Distribution of vasopressin and oxytocin in rat brain.
Open accessAbstract
Arginine-vasopressin and oxytocin in various portions of rat brain were determined by radioimmunoassays. The hormones were extracted from tissue samples into 0.1 N HCl and then purified partially with acetone-petroleum ether extraction. The non-equilibration method was used for the assays. In this method recovery rates of arginine-vasopressin and oxytocin were 73.0 +/- 4.4% and 75.0 +/- 3.8%, respectively. Sensitivities of the assays were 1 pg of arginine-vasopressin and 0.75 pg (0.3 microU) of oxytocin per assay tube. The higher concentrations of arginine-vasopressin and oxytocin were confirmed in the hypothalamo-neurohypophyseal system, where these hormones are synthesized, transported and stored. Relatively high concentrations of these hormones, especially oxytocin, were detected in spinal cord. Amygdala, hippocampus, limbic forebrain and pineal body contained a certain amount of arginine-vasopressin (2-20 pg/mg protein). Oxytocin (1-7 pg/mg protein) was also detected in amygdala, pons and medulla oblongata, pineal body and midbrain. The low concentrations of these hormones were also found in cerebral cortex and cerebellum.
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Low oxytocin concentrations are measured in rat cerebellum, but high densities of oxytocin receptors are localized in amygdala and also found in hippocampus, hypothalamus, thalamus, mesencephalon, and brainstem.
“Low concentrations of oxytocin have been measured in the cerebellum in rats [161] but high densities of oxytocin receptors (OTR) are localized in the amygdala and are also found in parts of the hippocampus, hypothalamus, thalamus, mesencephalon and brainstem.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [161]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029 · see citing works
The Pineal Gland: A Neurochemical Transducer
Axelrod, J. (1974) · Science · doi:10.1126/science.184.4144.1341 · Cited by 875 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830 · see citing works
Long Term Effect of Vasopressin on the Maintenance of a Conditioned Avoidance Response in Rats
de Wied, D. (1971) · Nature · doi:10.1038/232058a0 · Cited by 468 · see citing works
Wled, D. D. (1965) · International Journal of Neuropharmacology · doi:10.1016/0028-3908(65)90005-5 · Cited by 377 · see citing works
Immunofluorescence of vasopressin and oxytocin in the rat hypothalamo-neurohypophyseal system
Swaab, D. F., Pool, C. W., & Nijveldt, F. (1975) · Journal of Neural Transmission · doi:10.1007/bf01253126 · Cited by 323 · see citing works
Sofroniew, M. V. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.5.7381192 · Cited by 317 · cited 2× · see citing works
“Furthemore, recent immunohistochemical studies (Sofroniew, 1980; Buijs, 1980) on projections from VP, OXT and neurophysin neurons to neural targets demonstrated that neural target areas were found in portions of the limbic system, diencephalon , mesencephalon, brain stem and spinal cord and…”
Sofroniew, M. V., & Weindl, A. (1978) · American Journal of Anatomy · doi:10.1002/aja.1001530305 · Cited by 312 · see citing works
Nucleus Suprachiasmaticus: The Biological Clock in the Hamster?
Stetson, M. H., & Watson‐Whitmyre, M. (1976) · Science · doi:10.1126/science.942799 · Cited by 278 · see citing works
Identification of the vasopressin-neurophysin producing neurons of the rat suprachiasmatic nuclei
Vandesande, F., Dierickx, K., & Mey, J. D. (1975) · Cell and Tissue Research · doi:10.1007/bf00225365 · Cited by 248 · see citing works
Biological Rhythms and Animal Behavior
Rusak, B., & Zucker, I. (1975) · Annual Review of Psychology · doi:10.1146/annurev.ps.26.020175.001033 · Cited by 219 · see citing works
Circadian and Estrous Rhythms in Pineal Melatonin and 5-Hydroxy Indole-3-Acetic Acid.
Quay, W. B. (1964) · Experimental Biology and Medicine · doi:10.3181/00379727-115-29014 · Cited by 206 · see citing works
Arginine8-vasopressin affects catecholamine metabolism in specific brain nuclei
Tanaka, M., de Kloet, E. R., de Wied, D., & Versteeg, D. H. G. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90214-4 · Cited by 185 · see citing works
Sofroniew, M. V., & Weind, A. (1978) · Endocrinology · doi:10.1210/endo-102-1-334 · Cited by 153 · see citing works
The distribution of vasopressin and oxytocin in the rat brain
Dogterom, J., Snijdewint, F. G. M., & Buijs, R. M. (1978) · Neuroscience Letters · doi:10.1016/0304-3940(78)90206-9 · Cited by 129 · see citing works
Buijs, R. M. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.4.6989899 · Cited by 81 · see citing works
Hypothalamic neurons secreting vasopressin and neurophysin
Zimmerman, E. A., & ROBINSON, A. G. (1976) · Kidney International · doi:10.1038/ki.1976.75 · Cited by 80 · see citing works
Vasopressin modulates the activity of catecholamine containing neurons in specific brain regions
Versteeg, D. H. G., de Kloet, E. R., Greidanus, T. B. V. W., & de Wied, D. (1979) · Neuroscience Letters · doi:10.1016/0304-3940(79)90058-2 · Cited by 76 · see citing works
The involvement of catecholaminergic mechanisms in the behavioural action of vasopressin
Kovács, G. L., Vécsei, L., Szabó, G., & Telegdy, G. (1977) · Neuroscience Letters · doi:10.1016/0304-3940(77)90110-0 · Cited by 64 · see citing works
Effect of vasopressin on intracranial pressure of rabbit.
Noto, T., Nakajima, T., Saji, Y., & Nagawa, Y. (1978) · Endocrinologia Japonica · doi:10.1507/endocrj1954.25.591 · Cited by 39 · see citing works
Self-citationEffects of vasopressin and cyclic AMP on water transport at arachnoid villi of cats.
Noto, T., Nakajima, T., Saji, Y., et al. (1979) · Endocrinologia Japonica · doi:10.1507/endocrj1954.26.239 · Cited by 14 · see citing works
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Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
- Authors
- HASHIMOTO, H., FUKUI, K., NOTO, T., NAKAJIMA, T., & KATO, N.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Tokyo Metropolitan Matsuzawa Hospital (JP)
- ORCID
- FUKUI, KENJI
- Venue
- Endocrinologia Japonica
- Publisher
- Japan Endocrine Society
- Published
- 1985
- Volume
- 32
- Issue
- 1
- Pages
- 89-97
- ISSN
- 0013-7219 (ISSN-L)
- 2185-6370
- OpenAlex
- W2003901018
- Cited by
- 17
- References
- 22
- Citations by year
- 2026: 1 · 2024: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinologia Japonica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- vasopressin, oxytocin, brain distribution, hypothalamo-neurohypophysial system, spinal cord, amygdala, hippocampus, pineal gland, passive optical networks, medulla oblongata, cerebral cortex, cerebellum, rat brain
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Male, Oxytocin, Pituitary Gland, Posterior, Radioimmunoassay, Rats, Inbred Strains, Spinal Cord, Rats
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