Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human
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Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets were examined using the immunoperoxidase method. In the rat, neural target areas were found in portions of the limbic system, diencephalon, mesencephalon, brain stem, and spinal cord. In the human, only target areas in the brain stem and spinal cord were investigated. The projections to these targets derive from hypothalamic magnocellular vasopressin or oxytocin neurons, as well as from parvocellular vasopressin neurons of the suprachiasmatic nucleus. In neural target areas, axo somatic, as well as axodendritic, contacts are made. The findings suggest that these projections interact with other neurons, rather than release hormone into the bloodstream.
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Axonal release of oxytocin from the PVN may have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA).
“Axonal release of oxytocin from the PVN may also have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA)(25, 26, 27).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [26]
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Self-citationMechanisms of Transmitter Action in the Vertebrate Central Nervous System
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BackgroundHistochemical identification of a PVN-hindbrain feeding pathway
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- Authors
- Sofroniew, M. V.
- Corresponding author
- Sofroniew, M V
- ORCID
- Sofroniew, M V
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1980-05
- Volume
- 28
- Issue
- 5
- Pages
- 475-478
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W1991485877
- Cited by
- 317
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 4 · 2013: 7 · 2012: 7
- FWCI
- 37.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- vasopressin neurons, oxytocin neurons, hypothalamic magnocellular neurons, suprachiasmatic nucleus, parvocellular neurons, neuronal projections, limbic system, diencephalon, midbrain, brainstem, spinal cord, axosomatic synapses, axodendritic synapses, neuropeptide release, rats, human
- MeSH terms
- Animals, Axons, Brain Chemistry, Dendrites, Humans, Hypothalamus, Neurons, Neurophysins, Oxytocin, Paraventricular Hypothalamic Nucleus, Vasopressins, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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