A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

Paloyelis, Yannis; Doyle, Orla M.; Zelaya, Fernando O.; Maltezos, Stefanos; Williams, Steven C.; Fotopoulou, Aikaterini; Howard, Matthew A.

doi:10.1016/j.biopsych.2014.10.005

Cited by 187Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

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Paloyelis, Yannis, Doyle, Orla M., Zelaya, Fernando O., Maltezos, Stefanos, Williams, Steven C., Fotopoulou, Aikaterini, Howard, Matthew A.·2016·Biological Psychiatry

DOI 10.1016/j.biopsych.2014.10.005

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Abstract

BACKGROUND: Animal and human studies highlight the role of oxytocin in social cognition and behavior and the potential of intranasal oxytocin (IN-OT) to treat social impairment in individuals with neuropsychiatric disorders such as autism. However, extensive efforts to evaluate the central actions and therapeutic efficacy of IN-OT may be marred by the absence of data regarding its temporal dynamics and sites of action in the living human brain. METHODS: In a placebo-controlled study, we used arterial spin labeling to measure IN-OT-induced changes in resting regional cerebral blood flow (rCBF) in 32 healthy men. Volunteers were blinded regarding the nature of the compound they received. The rCBF data were acquired 15 min before and up to 78 min after onset of treatment onset (40 IU of IN-OT or placebo). The data were analyzed using mass univariate and multivariate pattern recognition techniques. RESULTS: We obtained robust evidence delineating an oxytocinergic network comprising regions expected to express oxytocin receptors, based on histologic evidence, and including core regions of the brain circuitry underpinning social cognition and emotion processing. Pattern recognition on rCBF maps indicated that IN-OT-induced changes were sustained over the entire posttreatment observation interval (25-78 min) and consistent with a pharmacodynamic profile showing a peak response at 39-51 min. CONCLUSIONS: Our study provides the first visualization and quantification of IN-OT-induced changes in rCBF in the living human brain unaffected by cognitive, affective, or social manipulations. Our findings can inform theoretical and mechanistic models regarding IN-OT effects on typical and atypical social behavior and guide future experiments (e.g., regarding the timing of experimental manipulations).

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It is doubtful how far intranasal oxytocin crosses the blood-brain barrier.
“doubt has been cast on the extent to which intranasal OXT crosses the blood-brain barrier (Neumann et al., 2013;Paloyelis et al., 2014;Striepens et al., 2013).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Paloyelis et al., 2014
There are uncertainties regarding the site and mechanism of action of exogenous intranasal oxytocin in humans due to lack of suitable radio tracers.
“Furthermore, there are uncertainties regarding the site and mechanism of action of exogenous intranasal oxytocin in humans due to lack of suitable radio tracers (Paloyelis et al., 2016).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Paloyelis et al., 2016
Intranasal oxytocin modulates neural responses in brain regions involved in threat detection and reward processing.
“intranasal administration of oxytocin has been shown to modulate neural responses in brain regions involved in threat detection and reward processing (Ma et al., 2016b; Paloyelis et al., 2016; Wang et al., 2017; Liu et al., 2019).”
From Oxytocin promotes coordinated out-group attack during intergroup conflict in humans (2019) · cites this paper as Paloyelis et al., 2016
An arterial spin labeling study showed that intranasal oxytocin increases cerebral blood flow in key regions of the social brain network, including ventral striatum, amygdala, hippocampus, caudate nucleus, anterior and middle cingulate cortices, anterior insula, ventral tegmental area, inferior frontal gyrus, inferior parietal cortex, and superior temporal gyrus.
“A recent elegant study using arterial spin labeling showed that IN-OT increases the levels of cerebral blood flow of key regions of the SBN such as ventral striatum, amygdala, hippocampus, caudate nucleus, anterior and middle cingulate cortices, anterior insula, ventral tegmental area (VTA), inferior frontal gyrus, inferior parietal cortex, and superior temporal gyrus (Paloyelis et al. 2016).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Paloyelis et al. 2016

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Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
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Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
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Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131 · see citing works
Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans
Martins, D., Mazibuko, N., Zelaya, F. O., Vasilakopoulou, S., Loveridge, J., Oates, A. E., Maltezos, S., Mehta, M. A., Wastling, S. J., Howard, M. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14845-5 · Cited by 130 · see citing works
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Preventive Treatments for Psychosis: Umbrella Review (Just the Evidence)
Fusar-Poli, P., Davies, C., Solmi, M., Brondino, N., De Micheli, A., Kotlicka-Antczak, M., Shin, J. I., & Radua, J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00764 · Cited by 108 · see citing works
The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107 · see citing works
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100 · see citing works
Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study
Daughters, K., Manstead, A. S. R., Hubble, K., Rees, A., Thapar, A., & van Goozen, S. H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145104 · Cited by 92 · see citing works
“[27] demonstrated that IN-OT also crosses the blood-brain barrier in human males, providing further evidence that IN-OT has direct effects on the brain.”
Background
Oxytocin modulates social value representations in the amygdala
Liu, Y., Li, S., Lin, W., Li, W., Yan, X., Wang, X., Pan, X., Rutledge, R. B., & Ma, Y. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0351-1 · Cited by 89 · see citing works
Oxytocin promotes coordinated out-group attack during intergroup conflict in humans
Zhang, H., Gross, J., De Dreu, C., & Ma, Y. (2019) · eLife · doi:10.7554/elife.40698 · Cited by 87 · see citing works
Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 84 · see citing works
Systematic review and meta‐analysis of reported adverse events of long‐term intranasal oxytocin treatment for autism spectrum disorder
Cai, Q., Feng, L., & Yap, K. Z. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12627 · Cited by 77 · see citing works
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 101 · see citing works
Oxytocin promotes intuitive rather than deliberated cooperation with the in-group
Ten Velden, F. S., Daughters, K., & De Dreu, C. K. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.005 · Cited by 66 · see citing works
Biomarkers, designs, and interpretations of resting‐state fMRI in translational pharmacological research: A review of state‐of‐the‐Art, challenges, and opportunities for studying brain chemistry
Khalili‐Mahani, N., Rombouts, S. A. R. B., van Osch, M. J. P., Duff, E. P., Carbonell, F., Nickerson, L. D. H., Becerra, L. R., Dahan, A., Evans, A. C., Soucy, J., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23516 · Cited by 61 · see citing works
Sex- and context-dependent effects of oxytocin on social sharing
Ma, X., Zhao, W., Luo, R., Zhou, F., Geng, Y., Xu, L., Gao, Z., Zheng, X., Becker, B., & Kendrick, K. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.004 · Cited by 64 · see citing works
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 62 · see citing works
A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin
Kou, J., Zhang, Y., Zhou, F., Sindermann, C., Montag, C., Becker, B., & Kendrick, K. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720003803 · Cited by 63 · see citing works
The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60 · see citing works
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61 · see citing works
Oxytocin and Social Cognition
Ebert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 62 · see citing works
Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 59 · see citing works
Oxytocin differentially modulates specific dorsal and ventral striatal functional connections with frontal and cerebellar regions
Zhao, Z., Ma, X., Geng, Y., Zhao, W., Zhou, F., Wang, J., Markett, S. A., Biswal, B. B., Ma, Y., Kendrick, K. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.067 · Cited by 55 · see citing works
Sniff and mimic–Intranasal oxytocin increases facial mimicry in a sample of men
Korb, S., Malsert, J., Strathearn, L., Vuilleumier, P., & Niedenthal, P. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.003 · Cited by 54 · see citing works
Anxiolytic Effects of Chronic Intranasal Oxytocin on Neural Responses to Threat Are Dose-Frequency Dependent
Kou, J., Zhang, Y., Zhou, F., Gao, Z., Yao, S., Zhao, W., Li, H., Lei, Y., Gao, S., Kendrick, K. M., et al. (2022) · Psychotherapy and Psychosomatics · doi:10.1159/000521348 · Cited by 54 · see citing works
Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action
Yao, S., & Kendrick, K. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020323 · Cited by 52 · see citing works
The role of trauma in the hormonal interplay of cortisol, testosterone, and oxytocin in adolescent aggression
Fragkaki, I., Cima, M., & Granic, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.11.005 · Cited by 52 · see citing works
The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
Uzefovsky, F., Bethlehem, R. A. I., Shamay-Tsoory, S., Ruigrok, A., Holt, R., Spencer, M., Chura, L., Warrier, V., Chakrabarti, B., Bullmore, E., et al. (2019) · Molecular Autism · doi:10.1186/s13229-019-0258-4 · Cited by 49 · see citing works
How does oxytocin modulate human behavior?
Yao, S., & Kendrick, K. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02898-1 · Cited by 55 · see citing works
Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 49 · see citing works
Oxytocin Differentially Modulates Amygdala Responses during Top‐Down and Bottom‐Up Aversive Anticipation
Xin, F., Zhou, X., Dong, D., Zhao, Z., Yang, X., Wang, Q., Gu, Y., Kendrick, K. M., Chen, A., & Becker, B. (2020) · Advanced Science · doi:10.1002/advs.202001077 · Cited by 46 · see citing works
The effects of intranasal oxytocin on smoothie intake, cortisol and attentional bias in anorexia nervosa
Leppänen, J., Cardi, V., Ng, K. W., Paloyelis, Y., Stein, D., Tchanturia, K., & Treasure, J. L. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.017 · Cited by 46 · see citing works
Oxytocin promotes face-sensitive neural responses to infant and adult faces in mothers
Peltola, M. J., Strathearn, L., & Puura, K. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.012 · Cited by 43 · see citing works
Intranasal oxytocin and OXTR genotype effects on resting state functional connectivity: A systematic review
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 42 · see citing works
Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.002 · Cited by 45 · see citing works
Oxytocin Modulates the Intrinsic Dynamics Between Attention-Related Large-Scale Networks
Xin, F., Zhou, F., Zhou, X., Ma, X., Geng, Y., Zhao, W., Yao, S., Dong, D., Biswal, B. B., Kendrick, K. M., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy295 · Cited by 39 · see citing works
Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.10.019 · Cited by 41 · see citing works
Intrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin
Jiang, X., Ma, X., Geng, Y., Zhao, Z., Zhou, F., Zhao, W., Yao, S., Yang, S., Zhao, Z., Becker, B., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117668 · Cited by 39 · see citing works
The role of machine learning in neuroimaging for drug discovery and development
Doyle, O., Mehta, M. A., & Brammer, M. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3968-0 · Cited by 41 · see citing works
A precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40 · see citing works
Oxytocin modulates meta-mood as a function of age and sex
Ebner, N. C., Horta, M., Lin, T., Feifel, D., Fischer, H., & Cohen, R. A. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00175 · Cited by 40 · see citing works
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38 · see citing works
Amygdala–Hippocampal Connectivity Is Associated With Endogenous Levels of Oxytocin and Can Be Altered by Exogenously Administered Oxytocin in Adults With Autism
Alaerts, K., Bernaerts, S., Vanaudenaerde, B. M., Daniëls, N., & Wenderoth, N. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.008 · Cited by 40 · see citing works
Oxytocin Facilitates Empathic- and Self-embarrassment Ratings by Attenuating Amygdala and Anterior Insula Responses
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00572 · Cited by 40 · see citing works
“Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain
Martins, D., Brodmann, K., Veronese, M., Dipasquale, O., Mazibuko, N., Schuschnig, U., Zelaya, F. O., Fotopoulou, A., & Paloyelis, Y. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102239 · Cited by 42 · see citing works
A dose-finding study of oxytocin using neurophysiological measures of social processing
Wynn, J. K., Green, M. F., Hellemann, G., Reavis, E. A., & Marder, S. R. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0165-y · Cited by 39 · see citing works
Oxytocin increases the pleasantness of affective touch and orbitofrontal cortex activity independent of valence
Chen, Y., Becker, B., Zhang, Y., Cui, H., Du, J. R., Wernicke, J., Montag, C., Kendrick, K. M., & Yao, S. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.08.003 · Cited by 39 · see citing works
Sniffing oxytocin: Nose to brain or nose to blood?
Yao, S., Chen, Y., Zhuang, Q., Zhang, Y., Lan, C., Zhu, S., Becker, B., & Kendrick, K. M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02075-2 · Cited by 38 · see citing works
In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing
Kou, J., Lan, C., Zhang, Y., Wang, Q., Zhou, F., Zhao, Z., Montag, C., Yao, S., Becker, B., & Kendrick, K. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01241-w · Cited by 37 · see citing works
Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans
Brodmann, K., Gruber, O., & Goya‐Maldonado, R. (2017) · Brain Connectivity · doi:10.1089/brain.2017.0528 · Cited by 34 · see citing works
Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study
Zunhammer, M., Geis, S., Busch, V., Eichhammer, P., & Greenlee, M. W. (2016) · Scientific Reports · doi:10.1038/srep31606 · Cited by 35 · see citing works
Oxytocin modulates third-party sanctioning of selfish and generous behavior within and between groups
Daughters, K., Manstead, A. S. R., Velden, F. S. T., & Dreu, C. K. W. D. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.039 · Cited by 35 · see citing works
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 33 · see citing works
Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design
Alaerts, K., Bernaerts, S., Prinsen, J., Dillen, C., Steyaert, J. G., & Wenderoth, N. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0653-8 · Cited by 35 · see citing works
How resource sharing resists scarcity: the role of cognitive empathy and its neurobiological mechanisms
Cui, F., Huang, X., Jing, Y., Luo, Y., Liu, J., & Gu, R. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac017 · Cited by 32 · see citing works
Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?
Betka, S., van Praag, C. G., Paloyelis, Y., Bond, R., Pfeifer, G., Sequeira, H., Duka, T., & Critchley, H. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy027 · Cited by 30 · see citing works
The Role of Intranasal Oxytocin on Social Cognition: an Integrative Human Lifespan Approach
Horta, M., Pehlivanoglu, D., & Ebner, N. C. (2020) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-020-00214-5 · Cited by 30 · see citing works
The Neuropeptide Oxytocin Enhances Information Sharing and Group Decision Making Quality
de Wilde, T. R. W., Velden, F. S. T., & Dreu, C. K. W. D. (2017) · Scientific Reports · doi:10.1038/srep40622 · Cited by 30 · see citing works
Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder: A double-blind placebo-controlled randomized trial
Grace, S., Labuschagne, I., Castle, D. J., & Rossell, S. L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.022 · Cited by 30 · see citing works
Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis
Davies, C., Paloyelis, Y., Rutigliano, G., Cappucciati, M., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Antoniades, M., Modinos, G., Oliver, D., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0311-6 · Cited by 28 · see citing works
Acute and Repeated Intranasal Oxytocin Differentially Modulate Brain-wide Functional Connectivity
Pagani, M., Felice, A. D., Montani, C., Galbusera, A., Papaleo, F., & Gozzi, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.036 · Cited by 27 · see citing works
Oxytocin receptor binding sites in the periphery of the neonatal mouse
Greenwood, M. A., & Hammock, E. A. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172904 · Cited by 27 · see citing works
The influence of oxytocin on eating behaviours and stress in women with bulimia nervosa and binge eating disorder
Leslie, M. R., Leppänen, J., Paloyelis, Y., & Treasure, J. L. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.014 · Cited by 27 · see citing works
Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males
Berends, Y. R., Tulen, J. H. M., Wierdsma, A. I., PELT, J. V., Feldman, R., Zagoory‐Sharon, O., de Rijke, Y. B., Kushner, S. A., & Marle, H. J. C. V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.027 · Cited by 27 · see citing works
Oral Administration of Oxytocin, Like Intranasal Administration, Decreases Top-Down Social Attention
Zhuang, Q., Zheng, X., Yao, S., Zhao, W., Becker, B., Xu, X., & Kendrick, K. M. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac059 · Cited by 26 · see citing works
Oxytocin amplifies sex differences in human mate choice
Xu, L., Becker, B., Luo, R., Zheng, X., Zhao, W., Zhang, Q., & Kendrick, K. M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104483 · Cited by 25 · see citing works
Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial
Straccia, M. A., Teed, A. R., Katzman, P. L., Tan, K. M., Parrish, M. H., Irwin, M. R., Eisenberger, N. I., Lieberman, M. D., & Tabak, B. A. (2021) · Psychological Medicine · doi:10.1017/s0033291721004104 · Cited by 25 · see citing works
Oxytocin-induced facilitation of learning in a probabilistic task is associated with reduced feedback- and error-related negativity potentials
Zhuang, Q., Zhu, S., Yang, X., Zhou, X., Xu, X., Chen, Z., Lan, C., Zhao, W., Becker, B., Yao, S., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120972347 · Cited by 23 · see citing works
Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review
Houghton, B., Kouimtsidis, C., Duka, T., Paloyelis, Y., & Bailey, A. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15617 · Cited by 23 · see citing works
Effects of intranasal oxytocin in food intake and craving: A meta-analysis of clinical trials
Chen, C., Chiang, Y.-C., Kuo, T., Tam, K., & Loh, E. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.08.011 · Cited by 22 · see citing works
Intranasal oxytocin increases heart-rate variability in men at clinical high risk for psychosis: a proof-of-concept study
Martins, D., Davies, C., Micheli, A. D., Oliver, D., Krawczun-Rygmaczewska, A., Fusar‐Poli, P., & Paloyelis, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00890-7 · Cited by 24 · see citing works
The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
Chen, Y., Li, Q., Zhang, Q., Kou, J., Zhang, Y., Cui, H., Wernicke, J., Montag, C., Becker, B., Kendrick, K. M., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.589878 · Cited by 23 · see citing works
Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging
Lussier, D., Cruz‐Almeida, Y., & Ebner, N. C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00338 · Cited by 20 · see citing works
Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects
Shcherbinin, S., Doyle, O., Zelaya, F. O., Simoni, S. D., Mehta, M. A., & Schwarz, A. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4021-z · Cited by 21 · see citing works
Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls
Martins, D., Leslie, M. R., Rodan, S., Zelaya, F. O., Treasure, J. L., & Paloyelis, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00871-w · Cited by 21 · see citing works
Imaging clinically relevant pain states using arterial spin labeling
Loggia, M. L., Segerdahl, A. R., Howard, M. A., & Tracey, I. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000750 · Cited by 21 · see citing works
Oxytocin increases the perceived value of both self- and other-owned items and alters medial prefrontal cortex activity in an endowment task.
Zhao, W., Geng, Y., Luo, L., Zhao, Z., Ma, X., Xu, L., Yao, S., & Kendrick, K. M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00272 · Cited by 20 · see citing works
Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women
Schultebraucks, K., Maslahati, T., Wingenfeld, K., Hellmann‐Regen, J., Kraft, J., Kownatzki, M., Behnia, B., Ripke, S., Otte, C., & Roepke, S. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01247-4 · Cited by 20 · see citing works
The influence of oxytocin on risk‐taking in the balloon analogue risk task among women with bulimia nervosa and binge eating disorder
Leslie, M. R., Leppänen, J., Paloyelis, Y., Nazar, B. P., & Treasure, J. L. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12771 · Cited by 20 · see citing works
Oxytocin normalizes the implicit processing of fearful faces in psychopathy: a randomized crossover study using fMRI
Tully, J., Sethi, A., Griem, J., Paloyelis, Y., Craig, M., Williams, S., Murphy, D., Blair, J., & Blackwood, N. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00067-3 · Cited by 18 · see citing works
Embodied Precision: Intranasal Oxytocin Modulates Multisensory Integration
Crucianelli, L., Paloyelis, Y., Ricciardi, L., Jenkinson, P. M., & Fotopoulou, A. (2018) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01366 · Cited by 19 · see citing works
Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia
Bradley, E., Brustkern, J., Coster, L. D., van den Bos, W., McClure, S. M., Seitz, A., & Woolley, J. D. (2019) · Psychological Medicine · doi:10.1017/s0033291719000552 · Cited by 19 · see citing works
Evaluating the efficacy of oxytocin for pain management: An updated systematic review and meta-analysis of randomized clinical trials and observational studies
Mekhael, A. A., Bent, J. E., Fawcett, J. M., Campbell, T. S., Aguirre‐Camacho, A., Farrell, A., & Rash, J. A. (2023) · Canadian Journal of Pain · doi:10.1080/24740527.2023.2191114 · Cited by 19 · see citing works
A phase II randomised controlled trial of intranasal oxytocin in anorexia nervosa
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Authors: Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A.
Affiliations: King's College London (GB)
University College London (GB)
Corresponding author: Paloyelis, Yannis
ORCID: Paloyelis, Yannis
Doyle, Orla M.
Zelaya, Fernando O.
Williams, Steven C.
Fotopoulou, Aikaterini
Howard, Matthew A.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2016-04
Volume: 79
Issue: 8
Pages: 693-705
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2014.10.005
OpenAlex: W2021223630
Cited by: 187
References: 154
Citations by year: 2026: 10 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 41 · 2019: 20 · 2018: 14 · 2017: 19 · 2016: 13 · 2015: 14
FWCI: 22.75
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Biological Psychiatry (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Portal (King's College London) (publishedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Funders: Economic and Social Research Council fellowship (ES/K009400/1)
Volkswagen Foundation “European Platform for Life Sciences, Mind Sciences and Humanities” (II/85 069)
Institute for the Study of Affective Neuroscience/Hope for Depression Research Foundation (to AF)
European Research Council Starting Investigator Award (ERC-2012-STG GA313755)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: intranasal oxytocin, regional cerebral blood flow, arterial spin labeling, oxytocin receptor, social cognition, emotional processing, pharmacodynamics, autism spectrum disorder, social dysfunction, spatiotemporal dynamics
MeSH terms: Administration, Intranasal, Brain, Brain Mapping, Central Nervous System Agents, Cerebrovascular Circulation, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Pattern Recognition, Automated, Rest, Multivariate Analysis, Single-Blind Method, Young Adult

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A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

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