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Cited by 254Influenza Virus Research StudiesAdipokines, Inflammation, and Metabolic DiseasesImmune responses and vaccinations

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Obesity Impairs the Adaptive Immune Response to Influenza Virus

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Green, William D., Beck, Melinda A.·2017·Annals of the American Thoracic Society
DOI 10.1513/annalsats.201706-447awPMC PMC5711276
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Abstract

Influenza, a highly contagious respiratory tract infection, affects millions of adults and children each year. Several high-risk populations include children, the elderly, the immunocompromised, and recently the obese. Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese. Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination. This challenges the current standard of protection for influenza and suggests that further vaccination methods or therapeutics are required to combat this virulent respiratory virus.

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Research works printed but not linked: 2

  1. Rolfes, Estimated influenza illnesses, medical visits, hospitalizations, and deaths averted by vaccination in the United States
  2. World Health Organization (WHO), Influenza (seasonal): fact sheet

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Metadata

Authors
Green, W. D., & Beck, M. A.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Beck, Melinda A.
ORCID
Venue
Annals of the American Thoracic Society
Publisher
Oxford University Press (OUP)
Published
2017-11-01
Volume
14
Issue
Supplement_5
Pages
S406-S409
ISSN
  • 2325-6621 (ISSN-L)
  • 2329-6933
DOI
10.1513/annalsats.201706-447aw
PMC
PMC5711276
OpenAlex
W2770679757
Cited by
253
References
33
Citations by year
2026: 6 · 2025: 13 · 2024: 14 · 2023: 25 · 2022: 43 · 2021: 72 · 2020: 64 · 2019: 11 · 2018: 3 · 2017: 1
FWCI
16.93
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Annals of the American Thoracic Society (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
obesity, influenza virus, adaptive immune response, influenza vaccination, vaccine response, cell-mediated immunity, influenza-like illness, respiratory infections
MeSH terms
Adult, Animals, Child, Disease Models, Animal, Humans, Influenza, Human, Influenza Vaccines, Obesity, Orthomyxoviridae Infections, Risk Factors, Mice, Adaptive Immunity

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