Cited by 365Obstructive Sleep Apnea ResearchAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

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Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation

Tasali, Esra, Ip, Mary S. M.·2008·Proceedings of the American Thoracic Society

DOI 10.1513/pats.200708-139mg

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Abstract

Metabolic syndrome (MS), the commonly used term for the clustering of obesity, insulin resistance, hypertension, and dyslipidemia, affects millions of people worldwide, and is associated with an increased risk of cardiovascular disease and type 2 diabetes. Recently, it has been suggested that obstructive sleep apnea (OSA), an increasingly prevalent condition, may contribute to the development of MS and diabetes. Despite substantial evidence from both clinical and population studies to suggest an independent link between OSA and metabolic abnormalities, the issue still remains controversial. Obesity, particularly visceral obesity, is an important factor in the assessment of adverse metabolic outcome in OSA. Further prospective and interventional studies, with adequate sample sizes and longer follow-up, rigorous control for adiposity, and, ideally, randomization and control for any therapeutic intervention, are clearly needed to address the direction of causality. There are multiple mechanistic pathways involved in the interaction between OSA, obesity, and metabolic derangements. Chronic intermittent hypoxia and sleep fragmentation with sleep loss in OSA are likely key triggers that initiate or contribute to the sustenance of inflammation as a prominent phenomenon, but their complex interplay remains to be elucidated. In summary, OSA may represent a novel risk factor for MS and diabetes, and thus clinicians should be encouraged to systematically evaluate the presence of metabolic abnormalities in OSA and vice versa.

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Authors: Tasali, E., & Ip, M. S. M.
Affiliations: University of Chicago (US)
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China
ORCID: Tasali, Esra
Venue: Proceedings of the American Thoracic Society
Publisher: Oxford University Press (OUP)
Published: 2008-02
Volume: 5
Issue: 2
Pages: 207-217
ISSN: 1546-3222 (ISSN-L)
1943-5665
DOI: 10.1513/pats.200708-139mg
OpenAlex: W1972056446
Cited by: 365
References: 136
Citations by year: 2026: 14 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 11 · 2021: 18 · 2020: 16 · 2019: 14 · 2018: 21 · 2017: 13 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 31 · 2012: 26
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Proceedings of the American Thoracic Society (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: National Center for Research Resources (P41RR013642)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obstructive sleep apnea, metabolic syndrome, glucose metabolism, insulin resistance, inflammation, intermittent hypoxia, sleep fragmentation, obesity, visceral obesity, type 2 diabetes, cardiovascular risk
MeSH terms: Adult, Blood Glucose, Humans, Inflammation, Risk Factors, Sleep Apnea, Obstructive, Metabolic Syndrome

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Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation

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