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Cited by 365Obstructive Sleep Apnea ResearchAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation

Tasali, Esra, Ip, Mary S. M.·2008·Proceedings of the American Thoracic Society
DOI 10.1513/pats.200708-139mg
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Abstract

Metabolic syndrome (MS), the commonly used term for the clustering of obesity, insulin resistance, hypertension, and dyslipidemia, affects millions of people worldwide, and is associated with an increased risk of cardiovascular disease and type 2 diabetes. Recently, it has been suggested that obstructive sleep apnea (OSA), an increasingly prevalent condition, may contribute to the development of MS and diabetes. Despite substantial evidence from both clinical and population studies to suggest an independent link between OSA and metabolic abnormalities, the issue still remains controversial. Obesity, particularly visceral obesity, is an important factor in the assessment of adverse metabolic outcome in OSA. Further prospective and interventional studies, with adequate sample sizes and longer follow-up, rigorous control for adiposity, and, ideally, randomization and control for any therapeutic intervention, are clearly needed to address the direction of causality. There are multiple mechanistic pathways involved in the interaction between OSA, obesity, and metabolic derangements. Chronic intermittent hypoxia and sleep fragmentation with sleep loss in OSA are likely key triggers that initiate or contribute to the sustenance of inflammation as a prominent phenomenon, but their complex interplay remains to be elucidated. In summary, OSA may represent a novel risk factor for MS and diabetes, and thus clinicians should be encouraged to systematically evaluate the presence of metabolic abnormalities in OSA and vice versa.

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Citations

Cites

Research works printed but not linked: 18

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Metadata

Authors
Tasali, E., & Ip, M. S. M.
Affiliations
  • University of Chicago (US)
  • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China
ORCID
Tasali, Esra
Venue
Proceedings of the American Thoracic Society
Publisher
Oxford University Press (OUP)
Published
2008-02
Volume
5
Issue
2
Pages
207-217
ISSN
  • 1546-3222 (ISSN-L)
  • 1943-5665
DOI
10.1513/pats.200708-139mg
OpenAlex
W1972056446
Cited by
365
References
136
Citations by year
2026: 14 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 11 · 2021: 18 · 2020: 16 · 2019: 14 · 2018: 21 · 2017: 13 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 31 · 2012: 26
FWCI
3.60
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Proceedings of the American Thoracic Society (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
National Center for Research Resources (P41RR013642)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obstructive sleep apnea, metabolic syndrome, glucose metabolism, insulin resistance, inflammation, intermittent hypoxia, sleep fragmentation, obesity, visceral obesity, type 2 diabetes, cardiovascular risk
MeSH terms
Adult, Blood Glucose, Humans, Inflammation, Risk Factors, Sleep Apnea, Obstructive, Metabolic Syndrome

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