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Cited by 59Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity

Lødrup Carlsen, Karin C., Mowinckel, Petter, Hovland, Vegard, Håland, Geir, Riiser, Amund, Carlsen, Kai-Håkon·2014·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2014.05.020
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Abstract

Background Childhood asthma phenotypes reflecting underlying developmental mechanisms are sought, with little information on asthma phenotypes based on allergic comorbidities.Objective We asked whether lung function trajectories from birth to 16 years were associated with asthma phenotypes with comorbid allergic rhinitis and atopic dermatitis.Methods Lung function (given as z scores) was measured at birth in 329 subjects in the "Environment and Childhood Asthma" birth cohort study in Oslo by using tidal flow volume loops, and at 10 and 16 years by using spirometry. Asthma phenotypes were classified on the basis of recurrent bronchial obstruction at 0 to 2 years, and asthma from the 2- to 10-year and 10- to 16-year intervals, and by combining asthma, atopic dermatitis, and/or allergic rhinitis from 10 to 16 years, stratifying for allergic sensitization. The reference group included 231 subjects without recurrent bronchial obstruction or asthma.Results Lung function trajectories differed significantly for asthma comorbidity phenotypes for FEV1, forced expiratory flow at 25% to 75% of forced vital capacity, and FEV1/forced vital capacity (all P < .0001). Significant lung function impairment was observed from birth through 16 years among subjects with asthma, atopic dermatitis, and allergic rhinitis. Lung function trajectories in subjects with asthma at 10 to 16 years or asthma in remission differed significantly for all 3 spirometric values compared with the trajectories in those who never had asthma (P < .0001), but not between asthma groups. Allergic sensitization was not significantly associated with asthma phenotype lung function trajectories.Conclusions The trajectory consisting of impaired lung function from birth throughout childhood in children with asthma, atopic dermatitis, and allergic rhinitis appears less likely to be driven by allergic sensitization, and may imply disease onset in utero, with clinical presentation later in childhood.

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  • Childhood asthma associated with allergic comorbidities, such as eczema and allergic rhinitis, has persistent lung function impairment from birth to adolescence compared to asthma without such comorbidities.

    “It has also been reported that childhood asthma associated with allergic comorbidities, such as eczema and allergic rhinitis, has persistent lung function impairment from birth to adolescence as compared to asthma without such comorbidities (156).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [156]

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Authors
Lødrup Carlsen, K. C., Mowinckel, P., Hovland, V., Håland, G., Riiser, A., & Carlsen, K.-H.
Affiliations
Oslo University Hospital (NO)
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2014-10
Volume
134
Issue
4
Pages
917-923.e7
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2014.05.020
OpenAlex
W2057630113
Cited by
59
References
39
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 3
FWCI
3.78
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
childhood asthma, asthma phenotypes, lung function trajectories, allergic rhinitis, atopic dermatitis, allergen sensitization, FEV1, forced expiratory flow, asthma comorbidity, birth cohort
MeSH terms
Adolescent, Asthma, Child, Child, Preschool, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Lung, Male, Norway, Phenotype, Puberty, Respiratory Function Tests, Cohort Studies, Comorbidity, Rhinitis, Allergic

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