The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
DNA Double-Strand Break Repair by Homologous Recombination
Abstract
The induction of double-strand breaks (DSBs) in DNA by exposure to DNA damaging agents, or as intermediates in normal cellular processes, constitutes a severe threat for the integrity of the genome. If not properly repaired, DSBs may result in chromosomal aberrations, which, in turn, can lead to cell death or to uncontrolled cell growth. To maintain the integrity of the genome, multiple pathways for the repair of DSBs have evolved during evolution: homologous recombination (HR), non-homologous end joining (NHEJ) and single-strand annealing (SSA). HR has the potential to lead to accurate repair of DSBs, whereas NHEJ and SSA are essentially mutagenic. In yeast, DSBs are primarily repaired via high-fidelity repair of DSBs mediated by HR, whereas in higher eukaryotes, both HR and NHEJ are important. In this review, we focus on the functional conservation of HR from fungi to mammals and on the role of the individual proteins in this process.
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Chromosomal stability and the DNA double-stranded break connection
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An alternative pathway for yeast telomere maintenance rescues est1− senescence
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
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In situ visualization of DNA double-strand break repair in human fibroblasts
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The controlling role of ATM in homologous recombinational repair of DNA damage
Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K., & Takeda, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.3.463 · Cited by 312 · cited 1×
“These observations indicate that ATM acts in concert with NHEJ to preserve the genome, through HR pathways (Morrison et al., 2000).”
BackgroundChk2 Activation Dependence on Nbs1 after DNA Damage
Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5214-5222.2001 · Cited by 201
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MOLECULAR AND EVOLUTIONARY BASIS OF THE CELLULAR STRESS RESPONSE
Kültz, D. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.103635 · Cited by 1,511
Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.002 · Cited by 1,424
Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
Vilenchik, M. M., & Knudson, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135498100 · Cited by 717
CRISPR-Cas: biology, mechanisms and relevance
Hille, F., & Charpentier, E. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0496 · Cited by 442
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
Rothgangl, T., Dennis, M. K., Lin, P. J. C., Oka, R., Witzigmann, D., Villiger, L., Qi, W., Hruzova, M., Kissling, L., Lenggenhager, D., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00933-4 · Cited by 378
Metadata
- Authors
- Bosch, M. V. D., Lohman, P. H. M., & Pastink, A.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2002-01-26
- Volume
- 383
- Issue
- 6
- Pages
- 873-92
- ISSN
- 1431-6730 (ISSN-L)
- OpenAlex
- W2043600941
- Cited by
- 169
- References
- 8
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bosch, M. V. D., Lohman, P. H. M., & Pastink, A. (2002). DNA Double-Strand Break Repair by Homologous Recombination. Biological Chemistry. https://doi.org/10.1515/bc.2002.095
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
