Glutathione Peroxidase, V. The kinetic mechanism
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During enzymatic reduction of hydrogen peroxide, selenocysteine undergoes sequential oxidation by hydrogen peroxide to form selenenic acid, followed by reaction with GSH to form a Se-SG intermediate before a second GSH combines to form GSSG, resolving the active site to Se-H.
“During the enzymatic reduction of hydrogen peroxide, Sec undergoes sequential oxidation by hydrogen peroxide to form a selenenic acid, Se-OH, followed by reaction with GSH to form a Se-SG intermediate before a second GSH combines to form GSSG, resolving the active site to Se-H (133, 278).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [133]
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Chem in Biochem Gue - roult Enzymol / this Biochim
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Flohe (1971) · Biophys Acta
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Necheles (1970) · Acta J Haematol
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Tappel, A. L. (1984) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152824-9.50015-0 · Cited by 96 · see citing works
Xiong, Y., Liu, X., Lee, C.-P., Chua, B. H. L., & Ho, Y.-S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.024 · Cited by 94 · see citing works
- Authors
- Flohé, L., Loschen, G., Günzler, W. A., & Eichele, E.
- ORCID
- Flohé, Leopold
- Venue
- Hoppe-Seyler´s Zeitschrift für physiologische Chemie
- Publisher
- Walter de Gruyter GmbH
- Published
- 1972-01
- Volume
- 353
- Issue
- 1
- Pages
- 987-1000
- ISSN
- 0018-4888 (ISSN-L)
- OpenAlex
- W2002449018
- Cited by
- 340
- References
- 3
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 6
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hoppe-Seyler´s Zeitschrift für physiologische Chemie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- glutathione peroxidase, enzyme kinetics, kinetic mechanism, hydrogen peroxide reduction, glutathione
- MeSH terms
- Animals, Cattle, Chemistry, Physical, Coumarins, Enzyme Activation, Glutathione, Hydrogen-Ion Concentration, Kinetics, Mathematics, Oxidation-Reduction, Peroxidases, Peroxides, Polarography, Spectrophotometry, Sulfates, Sulfhydryl Compounds, Titanium
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