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Low density lipoprotein increases amyloid precursor protein processing to amyloidogenic pathway in differentiated SH-SY5Y cells
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LDL exposure disrupts endolysosomal function in primary cortical neurons and neuronal cell lines.
“In parallel, studies examining the effects of native (non‐oxidized) and oxidized LDL (ox‐LDL) on brain cells have reported that LDL exposure in primary cortical neurons and neuronal cell lines disrupts endolysosomal function, increases amyloid‐β production, reduces synaptophysin levels, and induces mitochondrial dysfunction and oxidative stress (Engel et al. 2016; Hui et al. 2012; Yamchuen et al.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Yamchuen et al. 2017
LDL exposure induces oxidative stress in primary cortical neurons and neuronal cell lines.
“In parallel, studies examining the effects of native (non‐oxidized) and oxidized LDL (ox‐LDL) on brain cells have reported that LDL exposure in primary cortical neurons and neuronal cell lines disrupts endolysosomal function, increases amyloid‐β production, reduces synaptophysin levels, and induces mitochondrial dysfunction and oxidative stress (Engel et al. 2016; Hui et al. 2012; Yamchuen et al.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Yamchuen et al. 2017
LDL exposure induces mitochondrial dysfunction in primary cortical neurons and neuronal cell lines.
“In parallel, studies examining the effects of native (non‐oxidized) and oxidized LDL (ox‐LDL) on brain cells have reported that LDL exposure in primary cortical neurons and neuronal cell lines disrupts endolysosomal function, increases amyloid‐β production, reduces synaptophysin levels, and induces mitochondrial dysfunction and oxidative stress (Engel et al. 2016; Hui et al. 2012; Yamchuen et al.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Yamchuen et al. 2017
LDL exposure reduces synaptophysin levels in primary cortical neurons and neuronal cell lines.
“In parallel, studies examining the effects of native (non‐oxidized) and oxidized LDL (ox‐LDL) on brain cells have reported that LDL exposure in primary cortical neurons and neuronal cell lines disrupts endolysosomal function, increases amyloid‐β production, reduces synaptophysin levels, and induces mitochondrial dysfunction and oxidative stress (Engel et al. 2016; Hui et al. 2012; Yamchuen et al.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Yamchuen et al. 2017
LDL exposure increases amyloid-β production in primary cortical neurons and neuronal cell lines.
“In parallel, studies examining the effects of native (non‐oxidized) and oxidized LDL (ox‐LDL) on brain cells have reported that LDL exposure in primary cortical neurons and neuronal cell lines disrupts endolysosomal function, increases amyloid‐β production, reduces synaptophysin levels, and induces mitochondrial dysfunction and oxidative stress (Engel et al. 2016; Hui et al. 2012; Yamchuen et al.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Yamchuen et al. 2017
Citations
Cites
Cholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500
Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer's disease
Zhao, Z., Zhou, H., Peng, Y., Qiu, C. H., Sun, Q. Y., Wang, F., & Xie, H. N. (2014) · Genetics and Molecular Research · doi:10.4238/2014.october.20.19 · Cited by 19
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Cited by
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Baumart, G. J., Rodrigues, M. S., Sholl, J. N., de Sousa, A. C., Weber, A. F., Costa‐Beber, L. C., Farias, H. R., Costa, M. V., Peres, A. M., de Camargo, P. R., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70403 · Cited by 2
Metadata
- Authors
- Yamchuen, P., Jeenapongsa, R., Nudmamud-Thanoi, S., & Limpeanchob, N.
- Venue
- Biologia
- Published
- 2017-02
- Volume
- 72
- Issue
- 2
- Pages
- 238-244
- ISSN
- 0006-3088
- 1336-9563
- Cited by
- 2
- References
- 2
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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