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Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease
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Cholesterol oxidation products (oxysterols) that accumulate in the brain are key actors in Alzheimer's disease pathogenesis because they lead to neuron dysfunction and degeneration, mainly by enhancing oxidative stress and inflammation.
“For instance, cholesterol oxidation products (i.e., oxysterols) that accumulate in the brain are key actors in AD pathogenesis because they lead to neuron dysfunction and degeneration, mainly by enhancing oxidative stress and inflammation [11,14].”
From ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis (2022) · cites this paper as [11]
The association between cholesterol homeostasis alterations and Alzheimer's disease onset and progression has been evident for many years.
“The association between cholesterol homeostasis alterations and AD onset and progression has been evident for many years [11,12,13].”
From ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis (2022) · cites this paper as [11]
Oxysterols accumulating in the brain play a crucial role in AD development by enhancing oxidative stress and inflammation, with consequent neurodegeneration.
“Oxysterols accumulating in the brain certainly play a crucial role in AD development by enhancing oxidative stress and inflammation, with consequent neurodegeneration [11].”
From ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis (2022) · cites this paper as [11]
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Metadata
- Authors
- Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G.
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-06-19
- Volume
- 7
- ISSN
- 1663-4365
- PMC
- PMC4473000
- Cited by
- 180
- References
- 43
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