Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease
Open accessAbstract
BACKGROUND: Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer's disease (AD). Lack of holistic drugs for AD has reinvigorated enthusiasm in the natural product-based therapies. In this study, our idea to decipher the beneficial effects of C-phycocyanin (CPC) in the management of AD is buoyed by its multifaceted and holistic therapeutic effects. METHODS: -induced AD. Besides, the cognitive function was evaluated by the spatial memory performance on a radial arm maze. RESULTS: The results showed cognitive deficit in the mice with AD along with upregulated HDAC3 expression and diminished miRNA-335 and brain-derived neurotrophic factor (BDNF) expressions. In addition, inflammation was provoked (manifested by increased interleukins (IL)-6 and IL-1β) and neuronal apoptosis was accelerated (indicated by increased Bax, caspase-3, and caspase-9 along with decreased Bcl2) in the hippocampus of the mice with AD. Interestingly, CPC treatment in the mice with AD improved spatial memory performance and decreased the perturbations in the epigenetic and inflammatory biofactors. CONCLUSION: These results underscore that mitigation of inflammation via regulation of epigenetic factors might be the key pathway underlying the ameliorative effect of CPC against the aberrations in AD. Our findings provide the rationale for considering CPC as a viable therapeutic option in the management of AD.
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Several studies supported a protective role of C-PC through reduction in inflammation and neuronal apoptosis in response to neurodegeneration caused by oligomeric Aβ in mice.
“Several studies supported the protective role of C-PC through the reduction in inflammation and neuronal apoptosis in response to neurodegeneration caused by oligomeric Aβ in mice [141].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [141]
In the hippocampus of mice treated with oligomeric Aβ peptides, administration of C-PC increased miRNA-335 levels with reduced apoptosis and attenuated HDAC3 expression.
“In another article, it was demonstrated that in the hippocampus of mice treated with oligomeric Aβ peptides, the administration of C-PC increased miRNA-335 levels with reduced apoptosis and attenuated the expression of HDAC3 [141]”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [141]
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- Authors
- Li, Z., Gan, L., Yan, S., Yan, Y., & Huang, W.
- Affiliations
- Second Affiliated Hospital of Nanchang University (CN)
- Corresponding author
- Huang, Wei
- Venue
- Translational Neuroscience
- Publisher
- Walter de Gruyter GmbH
- Published
- 2020-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 161-172
- ISSN
- 2081-3856 (ISSN-L)
- 2081-6936
- PMC
- PMC7705988
- OpenAlex
- W3034049290
- Cited by
- 23
- References
- 62
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2024-05-31)
- Open access
- gold
- doi.org
- Locations
- Translational Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- C-phycocyanin, Alzheimer's disease, HDAC3, brain-derived neurotrophic factor, neuroinflammation, neuronal apoptosis, spatial memory, epigenetic regulation, amyloid-beta, tau pathology, natural product therapy, hippocampus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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