Interactions between folate and aging for carcinogenesis
Abstract
Inadequate folate intake and aging are each strongly implicated as important risk factors for certain cancers. Since both folate depletion and aging are strongly associated with hyperhomocysteinemia, genomic DNA hypomethylation, and increased uracil misincorporation into DNA, it appears that each of them enhances carcinogenesis by inducing a derangement of one-carbon metabolism that supplies one-carbons to biological methylation reactions and nucleotide synthesis. Recent studies have demonstrated that inadequate dietary folate and aging may interact and synergistically disturb the normal homeostasis of one-carbon metabolism, thereby provoking subsequent biochemical and molecular aberrations, including alterations in critical gene expression related to carcinogenesis. These studies have further indicated that modest folate supplementation may reverse or partially ameliorate those adverse effects induced by folate depletion and aging.
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Alcohol may alter one carbon metabolism by inhibiting folate absorption and folate cycle enzymes, leading to increased homocysteine concentrations.
“First, alcohol may alter the one carbon metabolism by inhibiting folate absorption, leading to increased homocysteine concentrations 150, 151, and by inhibiting folate cycle enzyme methionine synthase and the trans‐methylation enzymes methionine adenosyltransferase and DNA methyltransferase 150, 152.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [152]
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The relationship between different dimensions of alcohol use and the burden of disease—an update
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- Authors
- Choi, S.-W., & Friso, S.
- Affiliations
- Tufts University (US)
- Venue
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Publisher
- Walter de Gruyter GmbH
- Published
- 2005-01-01
- Volume
- 43
- Issue
- 10
- Pages
- 1151-7
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2066638714
- Cited by
- 49
- References
- 69
- Citations by year
- 2024: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- folic acid, aging, carcinogenesis, hyperhomocysteinemia, DNA hypomethylation, uracil misincorporation, one-carbon metabolism, folate depletion, folic acid supplementation, cancer risk factors, DNA methylation
- MeSH terms
- Aging, Animals, Carbon, Folic Acid, Humans, Neoplasms, DNA Methylation
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