Cited by 25Bacterial Genetics and BiotechnologyPhotosynthetic Processes and MechanismsBiochemical and Structural Characterization

Genomic insights into cyanobacterial protein translocation systems

Russo, David A., Zedler, Julie A. Z.·2020·Biological Chemistry

Abstract

Cyanobacteria are ubiquitous oxygenic photosynthetic bacteria with a versatile metabolism that is highly dependent on effective protein targeting. Protein sorting in diderm bacteria is not trivial and, in cyanobacteria, even less so due to the presence of a complex membrane system: the outer membrane, the plasma membrane and the thylakoid membrane. In cyanobacteria, protein import into the thylakoids is essential for photosynthesis, export to the periplasm fulfills a multifunctional role in maintaining cell homeostasis, and secretion mediates motility, DNA uptake and environmental interactions. Intriguingly, only one set of genes for the general secretory and the twin-arginine translocation pathways seem to be present. However, these systems have to operate in both plasma and thylakoid membranes. This raises the question of how substrates are recognized and targeted to their correct, final destination. Additional complexities arise when a protein has to be secreted across the outer membrane, where very little is known regarding the mechanisms involved. Given their ecological importance and biotechnological interest, a better understanding of protein targeting in cyanobacteria is of great value. This review will provide insights into the known knowns of protein targeting, propose hypotheses based on available genomic sequences and discuss future directions.

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Crossref · 10.1515/hsz-2020-0247

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Authors
Russo, D. A., & Zedler, J. A. Z.
Affiliations
Friedrich Schiller University Jena (DE)
Corresponding author
Zedler, Julie A. Z.
Venue
Biological Chemistry
Published
2020-10-12
Volume
402
Issue
1
Pages
39-54
ISSN
  • 1431-6730 (ISSN-L)
  • 1437-4315
OpenAlex
W3091917754
Cited by
25
References
121
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords
cyanobacteria, protein translocation, protein targeting, twin-arginine translocation, general secretory pathway, thylakoid membranes, outer membrane, periplasmic export, protein secretion, photosynthesis, membrane protein sorting, genome analysis
MeSH terms
Protein Translocation Systems, Cyanobacteria, Bacterial Proteins, Biological Transport

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