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Cited by 9Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

No Relationship Between Leptin and Cortisol in Obese Children and Adolescents

Sudi, K., Gallistl, S., Weinhandl, G., Payer, C., Cartellieri, M., Borkenstein, M.H.·2000·Journal of Pediatric Endocrinology and Metabolism
DOI 10.1515/jpem.2000.13.7.913
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Abstract

Recent findings have shown that leptin downregulates the steroid producing system in the adrenal. We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation. In 44 boys (age 11+/-3.1 yr, body mass index [BMI] 29+/-5.3 [mean +/- SD]) and 35 girls (age 11.4+/-2.6 yr, BMI 29+/-4.3), blood levels of leptin, insulin, cortisol, and glucose were determined. Fat mass (FM) was calculated by bioelectrical impedance. No significant differences were found between boys and girls with respect to humoral and anthropometric characteristics. When children were divided according to maturation stage (prepubertal, pubertal, and late/postpubertal) insulin was higher in the more mature groups (p<0.01) and leptin was higher in the pubertal group (p=0.03). In the prepubertal and pubertal groups, the expected positive relationship between adiposity and leptin was found although the magnitude of this association decreased with maturity. In none of the groups studied was cortisol significantly correlated to leptin. Insulin (p=0.03) and glucose (p=0.01) were positively associated with cortisol in the prepubertal group after adjustment for adiposity. However, in the pubertal group an inverse correlation was found between insulin and cortisol (p=0.03), and between insulin and glucose after control for adiposity. In the late/ postpubertal group, no significant correlations were found between estimates of adiposity and humoral parameters even after adjustment for gender. Stepwise multiple regression failed to detect a significant influence of cortisol to explain the variation in leptin, and vice versa. BMI contributed to the variation in leptin (adj. R2 =0.275, p<0.0001), and glucose added 5% to the variation in cortisol (p=0.03). The results do not confirm the inverse association between leptin and cortisol found in adults. Although BMI reflects levels of leptin, it is likely that several other factors in conjunction with fatness modulate the relationship with leptin. Whether leptin per se exerts an influence on the hypothalamic-adrenal-adipo axis remains to be investigated in longitudinal studies.

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Crossref · 10.1515/jpem.2000.13.7.913

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  • Studies have found no relationship between cortisol and leptin in children and adolescents when investigating the relation in a single morning measurement of serum cortisol.

    “Moreover, there are studies that did not find any relationship between cortisol and leptin in different groups such as children and adolescents investigating the relation in a single morning measurement of serum cortisol (49).”

    From Sparse System Identification of Leptin Dynamics in Women With Obesity (2022) · cites this paper as [49]

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Authors
Sudi, K., Gallistl, S., Weinhandl, G., Payer, C., Cartellieri, M., & Borkenstein, M. H.
Affiliations
University of Graz (AT)
ORCID
Cartellieri, M.
Venue
Journal of Pediatric Endocrinology and Metabolism
Publisher
Walter de Gruyter GmbH
Published
2000-01
Volume
13
Issue
7
Pages
913-21
ISSN
  • 0334-018X (ISSN-L)
  • 2191-0251
DOI
10.1515/jpem.2000.13.7.913
OpenAlex
W2328464903
Cited by
9
References
28
Citations by year
2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
leptin, cortisol, childhood obesity, adolescent obesity, puberty, insulin, hypothalamic-pituitary-adrenal axis, adiposity, body mass index
MeSH terms
Adolescent, Child, Female, Humans, Hydrocortisone, Male, Obesity, Leptin

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