Nutriepigenomics in perinatal medicine: maternal nutrition as a modulator of fetal gene expression and long-term health
Open accessAbstract
Introduction: Maternal nutrition during pregnancy can influence fetal development through epigenetic modifications, affecting gene expression without altering DNA sequence. Nutriepigenomics – the study of nutrient-driven epigenetic regulation – provides critical insights into how prenatal nutritional exposures can shape immediate and lifelong health outcomes. Content: This narrative review synthesizes evidence from human cohort studies and experimental animal models on how macro- and micronutrients, including folate, vitamin B12, choline, vitamin D, omega-3 fatty acids, and bioactive compounds such as polyphenols and resveratrol, modify key epigenetic processes. These include DNA methylation, histone modifications, and non-coding RNA regulation, particularly within the placenta and developing fetal tissues. Summary: Maternal diet-induced epigenetic changes influence fetal metabolic programming, neurodevelopment, immune maturation, and organogenesis, with impacts detectable at birth and persisting into adulthood. Evidence indicates associations with altered birthweight trajectories, increased risk of childhood obesity and immune dysregulation, and potential elevation in lifelong cardiometabolic and neuropsychiatric disease risk. Outlook: Integrating nutriepigenomic insights into perinatal care offers opportunities for early preventive strategies and personalized nutrition interventions. Translational application of epigenetic biomarkers, coupled with population-level nutritional policies, could reduce disease risk across generations and improve long-term population health outcomes.
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Such changes may also modify placental nutrient transport, promote compensatory nutrient delivery, and predispose offspring to metabolic disorders later in life.
“Such changes may also modify placental nutrient transport, promote compensatory nutrient delivery and predispose offspring to metabolic disorders later in life [18,173,174].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [173]
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Self-citationAndonotopo, W., Bachnas, M. A., Prabowo, W., Yuliantara, E. E., Pramono, M. B. A., Dewantiningrum, J., Lukas, E., Sanjaya, I. N. H., Wiradnyana, A. A. G. P., Kusuma, A. A. N. J., et al. (2026) · Journal of Advanced Trends in Medical Research · doi:10.4103/atmr.atmr_159_25
Self-citationAndonotopo, W., Pramono, M. B. A., Dewantiningrum, J., Bachnas, M. A., Prabowo, W., Sanjaya, I. N. H., Wiradnyana, A. A. G. P., Kusuma, A. A. N. J., Gumilar, K. E., Akbar, M. I. A., et al. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00492-7
Self-citationAndonotopo, W., Bachnas, M. A., Prabowo, W., Yuliantara, E. E., Pramono, M. B. A., Dewantiningrum, J., Lukas, E., Sanjaya, I. N. H., Wiradnyana, A. A. G. P., Kusuma, A. A. N. J., et al. (2025) · Dr Sulaiman Al Habib Medical Journal · doi:10.4103/dshmj.dshmj_65_25
Self-citationCasanova-Crespo, S., Ceballos-Sánchez, D., Rodríguez-Lagunas, M. J., Massot‐Cladera, M., Castell, M., & Pérez-Cano, F. J. (2026) · Food & Function · doi:10.1039/d5fo04563k
Kusuma, A. A. N. J., Andonotopo, W., Pramono, M. B. A., Dewantiningrum, J., Bachnas, M. A., Prabowo, W., Sanjaya, I. N. H., Wiradnyana, A. A. G. P., Gumilar, K. E., Akbar, M. I. A., et al. (2026) · Bangladesh Journal of Endocrinology and Metabolism · doi:10.4103/bjem.bjem_10_26
Self-citationLumbanraja, S. N., Aldiansyah, D., Lubis, M. P., Barus, M. N. G., Andonotopo, W., Bachnas, M. A., Prabowo, W., Yuliantara, E. E., Pramono, M. B. A., Dewantiningrum, J., et al. (2026) · Philippine Journal of Obstetrics and Gynecology · doi:10.4103/pjog.pjog_47_25
Self-citationAndonotopo, W., Aziz, A., Bernolian, N., Bachnas, M. A., Prabowo, W., Yuliantara, E. E., Pramono, M. B. A., Dewantiningrum, J., Lukas, E., Sanjaya, I. N. H., et al. (2026) · Environmental Disease · doi:10.4103/ed.ed_28_25
Self-citationAndonotopo, W., Bachnas, M. A., Pramono, M. B. A., Dewantiningrum, J., Lukas, E., Sanjaya, I. N. H., Wiradnyana, A. A. G. P., Kusuma, A. A. N. J., Gumilar, K. E., Darmawan, E., et al. (2026) · Journal of Perinatal Medicine · doi:10.1515/jpm-2026-0068
Self-citationLakhno, I. V. (2026) · Frontiers in Network Physiology · doi:10.3389/fnetp.2026.1864981
- Authors
- Andonotopo, W., Bachnas, M. A., Dewantiningrum, J., Adi Pramono, M. B., Sulistyowati, S., Hariyasa Sanjaya, I. N., Stanojevic, M., & Kurjak, A.
- Affiliations
- Fetomaternal Division , Women Health Center, Department of Obstetrics and Gynecology , Eka Hospital BSD , Serpong Tangerang, Banten , Indonesia
- Sebelas Maret University (ID)
- Diponegoro University (ID)
- Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia
- Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology , Faculty of Medicine Universitas Udayana, Prof. dr. I.G.N.G Ngoerah General Hospital , Denpasar , Bali , Indonesia
- Department of Neonatology and Rare Diseases , Medical University of Warsaw, Warsaw , Poland
- Department of Obstetrics and Gynecology , Medical School University of Zagreb , Zagreb , Croatia
- Corresponding author
- Andonotopo, Wiku
- Venue
- Journal of Perinatal Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2025-09-17
- Volume
- 54
- Issue
- 2
- Pages
- 244-257
- ISSN
- 0300-5577 (ISSN-L)
- 1619-3997
- OpenAlex
- W4414317451
- Cited by
- 15
- References
- 86
- Citations by year
- 2026: 10 · 2025: 5
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Perinatal Medicine (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- maternal nutrition, fetal gene expression, epigenetic regulation, DNA methylation, histone modifications, non-coding RNA, placenta, fetal programming, birth weight, childhood obesity, immune dysregulation, cardiometabolic disease, neuropsychiatric disorders, folic acid, vitamin B12, choline, vitamin D, omega-3 fatty acids, polyphenols, resveratrol, perinatal care, personalized nutrition, epigenetic biomarkers
- MeSH terms
- Animals, Female, Humans, Pregnancy, DNA Methylation, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development, Nutrigenomics
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