The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Regulation of Quantal Size by Presynaptic Mechanisms
Abstract
Quantal size is often modeled as invariant, although it is now well established that the number of transmitter molecules released per synaptic vesicle during exocytosis can be modulated in central and peripheral synapses. In this review, we suggest why presynaptically altered quantal size would be important at social synapses that provide extrasynaptic neurotransmitter. Current techniques used to measure quantal size are reviewed with particular attention to amperometry, the first approach to provide direct measurement of the number of molecules and kinetics of presynaptic quantal release, and to CNS dopamine neuronal terminals. The known interventions that alter quantal size at the presynaptic locus are reviewed and categorized as (1) alteration of transvesicular free energy gradients, (2) modulation of vesicle transmitter transporter activity, (3) modulation of fusion pore kinetics, (4) altered transmitter degranulation, and (5) changes in synaptic vesicle volume. Modulation of the number of molecules released per quantum underlies mechanisms of drug action of L-DOPA and the amphetamines, and seems likely to be involved in both normal synaptic modification and disease states. Statistical analysis for examining quantal size and data presentation is discussed. We include detailed information on performing nonparametric resampling statistical analysis, the Kolmogorov-Smirnov test for two populations, and random walk simulations using spreadsheet programs.
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Cites
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
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Extracellular space structure revealed by diffusion analysis
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Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli
Mirenowicz, J., & Schultz, W. (1996) · Nature · doi:10.1038/379449a0 · Cited by 829
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Self-citationSulzer, D., & Rayport, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90339-h · Cited by 389
Self-citationDissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327
Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus
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Cited by
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Striatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382
Self-citationAnalysis of exocytotic events recorded by amperometry
Mosharov, E. V., & Sulzer, D. (2005) · Nature Methods · doi:10.1038/nmeth782 · Cited by 349
Self-citationPresynaptic Regulation of Quantal Size by the Vesicular Glutamate Transporter VGLUT1
Wilson, N. R., Kang, J., Hueske, E. V., Leung, T., Varoqui, H., Murnick, J. G., Erickson, J. D., & Liu, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3003-04.2005 · Cited by 335
Lei, W., Jiao, Y., Del Mar, N., & Reiner, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1990-04.2004 · Cited by 277
Metadata
- Authors
- Sulzer, D., & Pothos, E. N.
- Venue
- Reviews in the Neurosciences
- Publisher
- Walter de Gruyter GmbH
- Published
- 2000-01
- Volume
- 11
- Issue
- 2-3
- Pages
- 159-212
- ISSN
- 0334-1763 (ISSN-L)
- 2191-0200
- OpenAlex
- W2065376500
- Cited by
- 184
- References
- 11
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
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