Kynurenic acid antagonists and kynurenine pathway inhibitors

Glycine potentiates the NMDA response in cultured mouse brain neurons

Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,151 · see citing works

Neuropharmacology of quinolinic and kynurenic acids.

Stone, T. W. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00441-7 · Cited by 949 · see citing works

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

Perkins, M. N., & Stone, T. W. (1982) · Brain Research · doi:10.1016/0006-8993(82)91048-4 · Cited by 849 · see citing works

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

Stone, T. W., & Perkins, M. N. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90587-2 · Cited by 751 · see citing works

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

Davies, J., Francis, A. A., Jones, A. W., & Watkins, J. C. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90061-6 · Cited by 464 · see citing works

Human macrophages convert l -tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Saito, K., & Markey, S. P. (1992) · Biochemical Journal · doi:10.1042/bj2830633 · Cited by 448 · see citing works

Schizophrenia and Glutamatergic Transmission

Tamminga, C. A. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.20 · Cited by 385 · see citing works

Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.

Birch, P., Grossman, C., & Hayes, A. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90367-6 · Cited by 324 · see citing works

Human microglia convert l -tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Achim, C. L., Wiley, C. A., Major, E. O., Saito, K., & Markey, S. P. (1996) · Biochemical Journal · doi:10.1042/bj3200595 · Cited by 260 · see citing works

Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl

Behan, W. M. H., McDonald, M., Darlington, L. G., & Stone, T. W. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702940 · Cited by 225 · see citing works

NMDA receptors and ligands in the vertebrate CNS

Stone, T. W. (1988) · Progress in Neurobiology · doi:10.1016/0301-0082(88)90027-5 · Cited by 223 · see citing works

Synthesis and Biochemical Evaluation ofN-(4-Phenylthiazol-2-yl)benzenesulfonamides as High-Affinity Inhibitors of Kynurenine 3-Hydroxylase

Röver, S., Cesura, A. M., Huguenin, P. N., Kettler, R., & Szente, A. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970467t · Cited by 212 · see citing works

Activated human microglia produce the excitotoxin quinolinic acid

Espey, M. G., Chernyshev, O. N., Reinhard, J. F., Namboodiri, M. A. A., & Colton, C. A. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00011 · Cited by 195 · see citing works

Kynurenate inhibition of cell excitation decreases stroke size and deficits

Germano, I. M., Pitts, L. H., Meldrum, B. S., et al. (1987) · Annals of Neurology · doi:10.1002/ana.410220609 · Cited by 189 · see citing works

Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

Hayes, M. P., Rubinow, D. R., Lane, C., et al. (1989) · Annals of Neurology · doi:10.1002/ana.410260215 · Cited by 189 · see citing works

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor

Leeson, P. D., Carling, R. W., Moore, K. W., et al. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00089a004 · Cited by 188 · see citing works

Cerestat and other NMDA antagonists in ischemic stroke

Lees, K. R. (1997) · Neurology · doi:10.1212/wnl.49.5_suppl_4.s66 · Cited by 184 · see citing works

NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment

Lipton, S. A. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.159 · Cited by 168 · see citing works

Kynurenine Hydroxylase Inhibitors Reduce Ischemic Brain Damage: Studies with ( m -Nitrobenzoyl)-Alanine (mNBA) and 3,4-Dimethoxy-[-N-4-(Nitrophenyl)Thiazol-2YL]-Benzenesulfonamide (Ro 61-8048) in Models of Focal or Global Brain Ischemia

Cozzi, A., Carpenedo, R., & Moroni, F. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199907000-00007 · Cited by 159 · see citing works

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor

Leeson, P. D., Baker, R., Carling, R. W., et al. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00108a002 · Cited by 146 · see citing works

Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

Rabey, J. M., Nissipeanu, P., & Korczyn, A. D. (1992) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260076 · Cited by 139 · see citing works

3'-(Arylmethyl)- and 3'-(Aryloxy)-3-phenyl-4-hydroxyquinolin- 2(1H)-ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor

Kulagowski, J. J., Baker, R., Curtis, N. R., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00036a002 · Cited by 139 · see citing works

Modulation of the Kynurenine Pathway in Search for New Neuroprotective Agents.Synthesis and Preliminary Evaluation of (m-Nitrobenzoyl)alanine, a Potent Inhibitor of Kynurenine-3-hydroxylase

Pellicciari, R., Natalini, B., Costantino, G., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00031a015 · Cited by 137 · see citing works

Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones

Perkins, M., Stone, T. W., Collins, J. F., et al. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90021-5 · Cited by 133 · see citing works

In vivo Models of Cerebral Ischemia: Effects of Parenterally Administered NMDA Receptor Glycine Site Antagonists

Warner, D. S., Martin, H., Ludwig, P., McAllister, A., Keana, J. F. W., & Weber, E. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.24 · Cited by 117 · see citing works

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

Ishimaru, M. J., Kurumaji, A., & Toru, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91197-5 · Cited by 114 · see citing works

The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

Eastman, C. L., & Guilarte, T. R. (1990) · Neurochemical Research · doi:10.1007/bf01101711 · Cited by 113 · see citing works

Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.

Baron, B. M., Harrison, B. L., Miller, F. P., McDonald, I. A., Salituro, F. G., Schmidt, C. J., Sorensen, S. M., White, H. S., & Palfreyman, M. G. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09491-x · Cited by 110 · see citing works

Comparison of the Neurochemical and Behavioral Effects Resulting from the Inhibition of Kynurenine Hydroxylase and/or Kynureninase

Chiarugi, A., Carpenedo, R., Molina, M. T., Mattoli, L., Pellicciari, R., & Moroni, F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031176.x · Cited by 105 · see citing works

(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats

Speciale, C., Wu, H., Cini, M., Marconi, M., Varasi, M., & Schwarcz, R. M. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00613-9 · Cited by 104 · see citing works

Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

Moroni, F., Russi, P., Gallo‐Mezo, M. A., et al. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb06361.x · Cited by 102 · see citing works

2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the N-methyl-D-aspartate (NMDA) receptor

Carling, R. W., Leeson, P. D., Moseley, A. M., et al. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00089a003 · Cited by 100 · see citing works

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-.alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Carling, R. W., Leeson, P. D., Moore, K. W., et al. (1993) · Journal of Medicinal Chemistry · doi:10.1021/jm00074a021 · Cited by 95 · see citing works

Nicotinylalanine Increases the Formation of Kynurenic Acid in the Brain and Antagonizes Convulsions

Russi, P., Alesiani, M., Lombardi, G., Davolio, P. L., Pellicciari, R., & Moroni, F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10097.x · Cited by 89 · see citing works

Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid

Harris, C. A., Miranda, A., Tanguay, J., et al. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701834 · Cited by 88 · see citing works

Kynurenine Disposition in Blood and Brain of Mice: Effects of Selective Inhibitors of Kynurenine Hydroxylase and of Kynureninase

Chiarugi, A., Carpenedo, R., & Moroni, F. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020692.x · Cited by 84 · see citing works

Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia

Simon, R. P., Young, R. S. K., Stout, S. C., et al. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90648-8 · Cited by 81 · see citing works

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo

Wu, H., Guidetti, P., Goodman, J. H., Varasi, M., Ceresoli‐Borroni, G., Speciale, C., Scharfman, H. E., & Schwarcz, R. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00030-0 · Cited by 79 · see citing works

Inhibition of Nitric Oxide Synthase Expression and Activity in Macrophages by 3-Hydroxyanthranilic Acid, a Tryptophan Metabolite

Sekkaı̈, D., Guittet, O., Lemaire, G., Tenu, J., & Lepoivre, M. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9913 · Cited by 79 · see citing works

Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid

Hokari, M., Wu, H., Schwarcz, R. M., et al. (1996) · Neuroreport · doi:10.1097/00001756-199612200-00004 · Cited by 78 · see citing works

Systemically administered d-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents

Battaglia, G., Russa, M. F. L., Bruno, V., Arenare, L., Ippolito, R., Copani, A., Bonina, F. P., & Nicoletti, F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01962-4 · Cited by 77 · see citing works

R‐(+)‐HA‐966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine

Hutson, P. H., Bristow, L. J., Thorn, L., et al. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12372.x · Cited by 75 · see citing works

Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus—infected rhesus macaques: Relationship to clinical and viral status

Heyes, M. P., Mefford, I. N., Quearry, B. J., Dedhia, M., & Lackner, A. A. (1990) · Annals of Neurology · doi:10.1002/ana.410270614 · Cited by 73 · see citing works

3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex

McQuaid, L. A., Smith, E. C., Lodge, D., et al. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00096a019 · Cited by 68 · see citing works

Chronic Changes in Synaptic Responses of Entorhinal and Hippocampal Neurons After Amino-Oxyacetic Acid (AOAA)–Induced Entorhinal Cortical Neuron Loss

Scharfman, H. E., Goodman, J. H., Du, F., & Schwarcz, R. M. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3031 · Cited by 68 · see citing works

4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine SiteN-Methyl- d -aspartate Antagonists withinVivoActivity

Carling, R. W., Leeson, P. D., Moore, K. W., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm9605492 · Cited by 67 · see citing works

S-Aryl-L-cysteine S,S-dioxides: design, synthesis, and evaluation of a new class of inhibitors of kynureninase

Dua, R. K., Taylor, E. W., & Phillips, R. S. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00057a007 · Cited by 66 · see citing works

The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.

Bristow, L. J., Flatman, K. L., Hutson, P. H., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12910-8 · Cited by 63 · see citing works

Competitive antagonism of glycine at the N-methyl-d-aspartate (NMDA) receptor

Huettner, J. E. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90004-o · Cited by 61 · see citing works

Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity

Connick, J. H., Heywood, G. C., Sills, G. J., Thompson, G., Brodie, M. J., & Stone, T. W. (1992) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(92)90017-e · Cited by 61 · see citing works

The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Possible Therapeutic Applications

Dannhardt, G., & Kohl, B. K. (1998) · Current Medicinal Chemistry · doi:10.2174/0929867305666220314214937 · Cited by 61 · see citing works

Glycine Site Antagonist Attenuates Infarct Size in Experimental Focal Ischemia

Takano, K., Tatlisumak, T., Formato, J. E., et al. (1997) · Stroke · doi:10.1161/01.str.28.6.1255 · Cited by 59 · see citing works

Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus

Wu, H., Lee, S.-C., & Schwarcz, R. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00024-8 · Cited by 56 · see citing works

Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

Bonina, F. P., Arenare, L., Ippolito, R., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00421-x · Cited by 55 · see citing works

An Open Trial of Glycine as an Adjunct to Neuroleptics in Chronic Treatment-Refractory Schizophrenics

COSTA, J., Khaled, E., Sramek, J. J., et al. (1990) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199002000-00027 · Cited by 54 · see citing works

Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists

Bigge, C. F. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90294-7 · Cited by 51 · see citing works

4-Halo-3-hydroxyanthranilic acids: Potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro

Walsh, J. L., Todd, W. P., Carpenter, B. K., & Schwarcz, R. M. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90279-e · Cited by 51 · see citing works

3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex

Salituro, F. G., Harrison, B. L., Baron, B. M., Nyce, P. L., Stewart, K. T., & McDonald, I. A. (1990) · Journal of Medicinal Chemistry · doi:10.1021/jm00173a003 · Cited by 50 · see citing works

Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: A preliminary study

Stone, T. W., & Perkins, M. N. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90184-8 · Cited by 48 · see citing works

Synthesis and Structure-Activity Relationships of Substituted 1,4-Dihydroquinoxaline-2,3-diones: Antagonists of N-Methyl-D-aspartate (NMDA) Receptor Glycine Sites and Non-NMDA Glutamate Receptors

Keana, J. F. W., Kher, S. M., Cai, S. X., et al. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00022a003 · Cited by 47 · see citing works

Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: Evidence for mediation by NMDA receptors

McMaster, O., Du, F., French, E. D., et al. (1991) · Experimental Neurology · doi:10.1016/0014-4886(91)90029-c · Cited by 46 · see citing works

Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.

Baron, B. M., Harrison, B. L., McDonald, I. A., et al. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10939-7 · Cited by 45 · see citing works

Novel indole-2-carboxylates as ligands for the strychnine-insensitive N-methyl-D-aspartate-linked glycine receptor

Gray, N. M., Dappen, M. S., Cheng, B. K., et al. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00108a007 · Cited by 45 · see citing works

Aminooxyacetic acid causes selective neuronal loss in layer III of the rat medial entorhinal cortex

Du, F., & Schwarcz, R. M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90591-t · Cited by 44 · see citing works

4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex

Harrison, B. L., Baron, B. M., Cousino, D. M., et al. (1990) · Journal of Medicinal Chemistry · doi:10.1021/jm00174a005 · Cited by 42 · see citing works

Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study

Du, F., Eid, T., & Schwarcz, R. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00354-0 · Cited by 41 · see citing works

NMDA-Associated glycine binding site increases in schizophrenic brains

Ishimaru, M. J., Kurumaji, A., & Toru, M. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90043-y · Cited by 41 · see citing works

Amantadine sulphate in treating Parkinson's disease: Clinical effects, psychometric tests and serum concentrations

Brenner, M., Haaß, A., Jacobi, P. R., et al. (1989) · Journal of Neurology · doi:10.1007/bf00314331 · Cited by 40 · see citing works

4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase

Heyes, M. P., Hutto, B., & Markey, S. P. (1988) · Neurochemistry International · doi:10.1016/0197-0186(88)90015-0 · Cited by 40 · see citing works

Glutamate antagonists and Parkinson's disease: A review of clinical data

Montastruc, J. L., Rascol, O., & Sénard, J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00035-8 · Cited by 39 · see citing works

Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices

Scharfman, H. E., Hodgkins, P., Lee, S.-C., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00690-4 · Cited by 38 · see citing works

Lamotrigine-antiparkinsonian activity by blockade of glutamate release?

Zipp, F., Baas, H. K. J., & Fischer, P.-A. (1993) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260916 · Cited by 37 · see citing works

A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo

Wood, E. R., Bussey, T. J., & Phillips, A. G. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90191-9 · Cited by 37 · see citing works

Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324

Priestley, T., Laughton, P., Macaulay, A. J., et al. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00141-4 · Cited by 36 · see citing works

Patent Update Central & Peripheral Nervous Systems: Glycine-site NMDA receptor antagonists: an update

Kulagowski, J. J. (1996) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.6.10.1069 · Cited by 36 · see citing works

Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro

Scharfman, H. E. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.2986 · Cited by 36 · see citing works

In Situ Produced 7-Chlorokynurenate Provides Protection against Quinolinate- and Malonate-Induced Neurotoxicity in the Rat Striatum

Guidetti, P., Wu, H., & Schwarcz, R. M. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7284 · Cited by 33 · see citing works

The N-methyl-d-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain

Hawkinson, J. E., Huber, K. R., Sahota, P. S., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01064-5 · Cited by 32 · see citing works

Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures

Chapman, A. G., Dürmüller, N., Harrison, B. L., et al. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00713-h · Cited by 32 · see citing works

ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats

Kretschmer, B. D., Kratzer, U., Breithecker, K., et al. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01047-9 · Cited by 32 · see citing works

Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro

Scharfman, H. E., & Goodman, J. H. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00073-6 · Cited by 32 · see citing works

Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists

Leeson, P. D., Baker, R., Carling, R. W., et al. (1993) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)80897-0 · Cited by 32 · see citing works

Quinolinic Acid and the Kynurenines

Stone, T. W. (1988) · Medical Entomology and Zoology · Cited by 32 · see citing works

Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist

Brady, R. J., & Swann, J. W. (1988) · Epilepsy Research · doi:10.1016/0920-1211(88)90013-7 · Cited by 30 · see citing works

Binding of the radiolabeled glycine site antagonist [3H]MDL 105,519 to homomeric NMDA-NR1a receptors

Siegel, B. W., Sreekrishna, K., & Baron, B. M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00477-3 · Cited by 30 · see citing works

6-Chloro-d,l-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation

Saito, K., Markey, S. P., & Heyes, M. P. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90761-7 · Cited by 30 · see citing works

Review Central & Peripheral Nervous Systems: Glycine-site NMDA receptor antagonists

Kulagowski, J. J., & Leeson, P. D. (1995) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.5.10.1061 · Cited by 29 · see citing works

N-methyl-D-aspartate antagonists for stroke and head trauma

Wood, P. L., & Hawkinson, J. E. (1997) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.6.4.389 · Cited by 28 · see citing works

Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase

Varasi, M., TORRE, A. D., Heidempergher, F., et al. (1996) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(96)80002-x · Cited by 28 · see citing works

Synthesis and SAR of 4-Aryl-2-hydroxy-4-oxobut-2-enoic Acids and Esters and 2-Amino-4-aryl-4-oxobut-2-enoic Acids and Esters: Potent Inhibitors of Kynurenine-3-hydroxylase as Potential Neuroprotective Agents

Drysdale, M. J., Hind, S. L., Jansen, M., & Reinhard, J. F. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990396t · Cited by 28 · see citing works

Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices

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Role of kynurenines in the neurotoxic actions of kainic acid

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