Cited by 751Tryptophan and brain disordersNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

Stone, T.W., Perkins, M.N.·1981·European Journal of Pharmacology

Integrity signals

Registry

Crossref · 10.1016/0014-2999(81)90587-2

Cites

4 of 4 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Claims other papers make about this one

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  • Activation of the TRYCAT pathway diverts tryptophan metabolism away from serotonin synthesis, generating neurotoxic metabolites such as quinolinic acid that can overstimulate NMDA receptors and exacerbate mood dysregulation.

    “Of note, activation of the TRYCAT pathway diverts tryptophan metabolism away from serotonin synthesis, generating neurotoxic metabolites such as quinolinic acid that can overstimulate N-methyl-D-aspartate (NMDA) receptors and exacerbate mood dysregulation (77).”
  • Resulting cortisol dysregulation promotes microglial activation and elevated pro-inflammatory cytokines, particularly IL-6, which divert tryptophan metabolism toward neurotoxic kynurenine pathway products and away from serotonin synthesis.

    “Resulting cortisol dysregulation promotes microglial activation and elevated pro-inflammatory cytokines, particularly IL-6, which divert tryptophan metabolism toward neurotoxic kynurenine pathway products and away from serotonin synthesis (77).”

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Authors
Stone, T. W., & Perkins, M. N.
Affiliations
University of London (GB)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1981-07
Volume
72
Issue
4
Pages
411-412
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2075010970
Cited by
751
References
4
Citations by year
2026: 12 · 2025: 12 · 2024: 23 · 2023: 29 · 2022: 27 · 2021: 27 · 2020: 22 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 26 · 2015: 27 · 2014: 16 · 2013: 23 · 2012: 22
FWCI
8.91
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
quinolinic acid, amino acid receptors, excitatory neurotransmission, central nervous system, major depressive disorder, inflammatory cytokines, glucocorticoids, corticotropin-releasing factor, network centrality, therapeutic target
MeSH terms
Action Potentials, Animals, Cerebral Cortex, Male, Pyridines, Quinolinic Acids, Receptors, Cell Surface, Quinolinic Acid, Receptors, Amino Acid, Rats

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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