Investigational drugs for fracture healing: preclinical & clinical data
Abstract
INTRODUCTION: The need for fracture healing enhancement for the management of fracture complications such as non-union and for the achievement of early function in fracture patients is constantly increasing. Therefore, the development and evaluation of novel pharmaceutical agents is mandatory in order to accelerate the process and increase bone union rates. AREAS COVERED: This review summarizes the most recent knowledge on the pharmacological enhancement of fracture repair. It provides a synopsis of the most important preclinical and clinical studies published over the past five years on long bone fracture healing. EXPERT OPINION: To date, limited drugs seem to have the potential for clinical use in fracture healing enhancement and the field is progressing very slowly. Among anti-osteoporotic drugs, only PTH and anti-sclerostin antibodies have such a potential but further research is needed before clinical use. The same applies also to BMPs, the use of which still carries major drawbacks that should be overcome before their widespread clinical utilization. Other drugs and growth factors, such as statins, VEGF, FGF, EPO, could be future key players in fracture healing but evidence is still lacking. Further in depth understanding of the healing process is essential in order to identify novel effective pharmacological agents.
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There is a lack of evidence from clinical studies in patients for selective prostaglandin agonists, cyasterone, statins, and anti-sclerostin antibodies as fracture-healing accelerators.
“Other drugs that have been considered to accelerate fracture healing include selective prostaglandin agonists (111), cyasterone (112), statins, and anti-sclerostin antibodies (113), but there is a lack of evidence from clinical studies in patients.”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [113]
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Methods to accelerate fracture healing – a narrative review from a clinical perspective
Ganse, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1384783 · Cited by 33 · see citing works
- Authors
- E. Klontzas, M., I. Kenanidis, E., J. MacFarlane, R., Michail, T., E. Potoupnis, M., Heliotis, M., Mantalaris, A., & Tsiridis, E.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- London North West Healthcare NHS Trust (GB)
- Imperial College London (GB)
- Corresponding author
- Tsiridis, Eleftherios
- Venue
- Expert Opinion on Investigational Drugs
- Publisher
- Informa Healthcare
- Published
- 2016-03-28
- Volume
- 25
- Issue
- 5
- Pages
- 585-596
- ISSN
- 1354-3784 (ISSN-L)
- 1744-7658
- OpenAlex
- W2326833633
- Cited by
- 32
- References
- 126
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Investigational Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- fracture healing, nonunion, long bone fractures, parathyroid hormone, anti-sclerostin antibody, bone morphogenetic proteins, growth factors, statins, vascular endothelial growth factor, fibroblast growth factor, erythropoietin, osteoporosis drugs, pharmacological agents
- MeSH terms
- Animals, Humans, Osteoporosis, Drugs, Investigational, Fracture Healing, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Bone Morphogenetic Proteins, Fractures, Bone
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