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An update on pharmacotherapy for leishmaniasis

Open access
Sundar, Shyam, Chakravarty, Jaya·2015·Expert Opinion on Pharmacotherapy

Abstract

INTRODUCTION: Leishmaniasis broadly manifests as visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis. The treatment of leishmaniasis is challenging and the armamentarium of drugs is small, duration of treatment is long, and most drugs are toxic. AREAS COVERED: A literature search on treatment of leishmaniasis was done on PubMed. Single dose of liposomal amphotericin B (L-AmB) and multidrug therapy (L-AmB + miltefosine, L-AmB + paromomycin (PM), or miltefosine + PM) are the treatment of choice for VL in the Indian subcontinent. A 17-day combination therapy of pentavalent antimonials (Sb(v)) and PM remains the treatment of choice for East African VL. L-AmB at a total dose of 18 - 21 mg/kg is the recommended regimen for VL in the Mediterranean region and South America. Treatment of CL should be decided by the severity of clinical lesions, etiological species and its potential to develop into mucosal leishmaniasis. EXPERT OPINION: There is an urgent need to implement a single-dose L-AmB or combination therapy in the Indian subcontinent. Shorter and more acceptable regimens are needed for the treatment of post - kala-azar dermal leishmaniasis. Combination therapy with newer drugs needs to be tested in Africa. Due to the toxicity of systemic therapy, a trend toward local treatment for New World CL is preferred in patients without risk of mucosal disease.

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Metadata

Authors
Sundar, S., & Chakravarty, J.
Venue
Expert Opinion on Pharmacotherapy
Published
2014-10-25
Volume
16
Issue
2
Pages
237-252
ISSN
  • 1465-6566 (ISSN-L)
  • 1744-7666
OpenAlex
W2087503664
Cited by
320
References
57
FWCI
16.55
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: An update on pharmacotherapy for leishmaniasis. https://app.cochat.ai/papers/10.1517/14656566.2015.973850
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Sundar, S., & Chakravarty, J. (2015). An update on pharmacotherapy for leishmaniasis. Expert Opinion on Pharmacotherapy. https://doi.org/10.1517/14656566.2015.973850

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