The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tendon healing and platelet-rich plasma therapies
Abstract
IMPORTANCE OF THE FIELD: The therapeutic use of platelet-rich plasma (PRP) is an autologous biotechnology that relies on the local delivery of a wide range of growth factors and cytokines with the aim of enhancing tissue healing. Understanding both tendon healing and PRP therapies is an area of research that is critically important in developing optimal formulations and protocols to achieve the intended therapeutic effects. AREAS COVERED IN THIS REVIEW: We summarise recent information on the mechanisms inherent to the earliest response to tendon injury. We then describe the positive effect of PRP therapies on tendon healing. Research on tendinopathy has produced several biological hypotheses based on histopathological, biochemical and clinical findings showing that cell apoptosis, angiofibroblastic features or abnormal biochemical adaptations underlie the condition. WHAT THE READER WILL GAIN: The article provides insights into early healing mechanisms and the influence of PRP therapies on inflammation, cell migration, angiogenesis and the proliferation and synthesis of extracellular matrix. The knowledge gained helps to better understand and optimize tendon therapies. TAKE HOME MESSAGE: The use of endogenous therapies has a positive effect on experimental tendon healing. However, several obstacles need to be addressed to optimise medical practice in this field.
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Citations
Cites
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · cited 1×
“Although the normal tendon is essentially devoid of neural components [6], ummyelinated axons that innervate the peritendon (adjacent loose connective tissue) and endotenon sense the molecular products of injury and transmit signals to modulate the efferent neural responses along with the immune responses [7].”
BackgroundMacrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694
Accelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525
Clearance of apoptotic and necrotic cells and its immunological consequences
Krysko, D. V., D’Herde, K., & Vandenabeele, P. (2006) · Apoptosis · doi:10.1007/s10495-006-9527-8 · Cited by 316
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Cited by
Azeredo, E. L. D., Monteiro, R. Q., & de-Oliveira Pinto, L. M. (2015) · Mediators of Inflammation · doi:10.1155/2015/313842 · Cited by 288
Yan, R., Gu, Y., Ran, J., Hu, Y., Zheng, Z., Zeng, M., Heng, B. C., Chen, X., Yin, Z., Chen, W., et al. (2017) · The American Journal of Sports Medicine · doi:10.1177/0363546517694357 · Cited by 124
Autologous Platelet-Rich Plasma: A Revolution in Soft Tissue Sports Injury Management?
Mei-Dan, O., Lippi, G., Sánchez, M., Andia, I., & Maffulli, N. (2010) · The Physician and Sportsmedicine · doi:10.3810/psm.2010.12.1835 · Cited by 83
Self-citationJiang, G., Wu, Y., Meng, J., Wu, F., Li, S., Lin, M., Gao, X., Hong, J., Chen, W., Yan, S., et al. (2020) · The American Journal of Sports Medicine · doi:10.1177/0363546520906142 · Cited by 59
Zhang, J., Nie, D., Williamson, K., Rocha, J. L., Hogan, M. V., & Wang, J. H.-C. (2019) · Journal of Tissue Engineering · doi:10.1177/2041731418820034 · Cited by 25
Metadata
- Authors
- Andia, I., Sanchez, M., & Maffulli, N.
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa UK Limited
- Published
- 2010-08-18
- Volume
- 10
- Issue
- 10
- Pages
- 1415-1426
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W1968212841
- Cited by
- 166
- References
- 9
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
