Cited by 164NF-κB Signaling PathwaysNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

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Srinivasan, Mythily, Lahiri, Debomoy K·2015·Expert Opinion on Therapeutic Targets

DOI 10.1517/14728222.2014.989834PMC PMC5873291

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Abstract

INTRODUCTION: Advances in molecular pathogenesis suggest that the chronic inflammation is a shared mechanism in the initiation and progression of multiple neurodegenerative diseases with diverse clinical manifestations such as Alzheimer's disease (AD) and Multiple sclerosis (MS). Restricted cell renewal and regenerative capacity make the neural tissues extremely vulnerable to the uncontrolled inflammatory process leading to irreversible tissue damage. AREAS COVERED: A predominant consequence of increased inflammatory signaling is the upregulation of the transcription factor, NF-κB with subsequent neuroprotective or deleterious effects depending on the strength of the signal and the type of NF-κB dimers activated. We discuss the interplay between neuroinflammation and neurodegeneration keeping in focus NF-κB signaling as the point of convergence of multiple pathways associated with the development of the neurodegenerative pathologies, AD and MS. EXPERT OPINION: Considerable interest exists in developing efficient NF-κB inhibitors for neurodegenerative diseases. The review includes an overview of natural compounds and rationally designed agents that inhibit NF-κB and mediate neuroprotection in AD and MS. The key chemical moieties of the natural and the synthetic compounds provide efficient leads for the development of effective small molecule inhibitors that selectively target NF-κB activation; this would result in the desired benefit to risk therapeutic effects.

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Authors: Srinivasan, M., & Lahiri, D. K.
Affiliations: Indiana University (US)
Indiana University School of Medicine (US)
ORCID: Srinivasan, Mythily
Lahiri, Debomoy K
Venue: Expert Opinion on Therapeutic Targets
Publisher: Informa UK Limited
Published: 2015-02-04
Volume: 19
Issue: 4
Pages: 471-487
ISSN: 1472-8222 (ISSN-L)
1744-7631
DOI: 10.1517/14728222.2014.989834
PMC: PMC5873291
OpenAlex: W1973257468
Cited by: 164
References: 108
Citations by year: 2026: 10 · 2025: 12 · 2024: 11 · 2023: 13 · 2022: 16 · 2021: 21 · 2020: 19 · 2019: 16 · 2018: 19 · 2017: 10 · 2016: 10 · 2015: 6
FWCI: 4.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Expert Opinion on Therapeutic Targets (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Purdue University Indianapolis (Indiana University) (submittedVersion)
Author eBooks
Funders: National Institutes of Health (5r21ag042804-02)
National Institute on Aging (R21-AG042804, 5R21AG042804, 1R21AG047)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: NF-κB signaling, Alzheimer's disease, multiple sclerosis, neuroinflammation, neurodegeneration, NF-κB inhibitors, neuroprotection, natural compounds, small molecule inhibitors, chronic inflammation
MeSH terms: Alzheimer Disease, Animals, Humans, Multiple Sclerosis, Drug Design, Signal Transduction, Up-Regulation, NF-kappa B, Neuroprotective Agents

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

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