Retracted: Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice
Abstract
Evidence suggests that curcumin, the phytochemical agent in the spice turmeric, might be a potential therapy for Alzheimer's disease (AD). Its antioxidant, anti-inflammatory properties have been investigated extensively. Studies have also shown that curcumin can reduce amyloid pathology in AD. The underlying mechanism, however, is complex and is still being explored. In this study, we used the APPswe/PS1dE9 double transgenic mice, an AD model, to investigate the effects and mechanisms of curcumin in the prevention and treatment of AD. The water maze test indicated that curcumin can improve spatial learning and memory ability in mice. Immunohistochemical staining and Western blot analysis were used to test major proteins in β-amyloid aggregation, β-amyloid production, and β-amyloid clearance. Data showed that, 3 months after administration, curcumin treatment reduced Aβ40 , Aβ42 , and aggregation of Aβ-derived diffusible ligands in the mouse hippocampal CA1 area; reduced the expression of the γ-secretase component presenilin-2; and increased the expression of β-amyloid-degrading enzymes, including insulin-degrading enzymes and neprilysin. This evidence suggests that curcumin, as a potential AD therapeutic method, can reduce β-amyloid pathological aggregation, possibly through mechanisms that prevent its production by inhibiting presenilin-2 and/or by accelerating its clearance by increasing degrading enzymes such as insulin-degrading enzyme and neprilysin.
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Curcumin can reverse cognitive deficits in numerous animal models of AD.
“Curcumin also has the ability to reverse cognitive deficits in numerous animal models of AD [163,164,165].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [164]
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- Authors
- Wang, P., Su, C., Li, R., Wang, H., Ren, Y., Sun, H., Yang, J., Sun, J., Shi, J., Tian, J., & Jiang, S.
- Affiliations
- Beijing University of Chinese Medicine (CN)
- McMaster University (CA)
- Xinjiang Medical University (CN)
- Amcare Women and Children's Hospital Beijing China
- Key Laboratory of Chinese Internal Medicine Ministry of Education, Beijing University of Chinese Medicine (BUCM) China
- Corresponding author
- Tian, Jinzhou
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2013-11-23
- Volume
- 92
- Issue
- 2
- Pages
- 218-231
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1486653930
- Cited by
- 65
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 14 · 2015: 8 · 2014: 2 · 2013: 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2020-01-06)
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81073076)
- Beijing Natural Science Foundation (7092057)
- IRT (0810)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease, APP/PS1 mice, spatial learning and memory, amyloid-beta aggregation, amyloid-beta production, presenilin 2, gamma-secretase, insulin-degrading enzyme, neprilysin, amyloid clearance, hippocampus, retraction
- MeSH terms
- Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Curcumin, Disease Models, Animal, Immunohistochemistry, Memory, Mice, Inbred C57BL, Mice, Transgenic, Blotting, Western, Maze Learning, Mice
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