Cited by 65Alzheimer's disease research and treatmentsCurcumin's Biomedical ApplicationsMedicinal Plants and Neuroprotection

Retracted: Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

Wang, Pengwen, Su, Caixin, Li, Ruisheng, Wang, Hong, Ren, Ying, Sun, Haiyun, Yang, Jinduo, Sun, Jianning +3 more·2014·Journal of Neuroscience Research

Abstract

Evidence suggests that curcumin, the phytochemical agent in the spice turmeric, might be a potential therapy for Alzheimer's disease (AD). Its antioxidant, anti-inflammatory properties have been investigated extensively. Studies have also shown that curcumin can reduce amyloid pathology in AD. The underlying mechanism, however, is complex and is still being explored. In this study, we used the APPswe/PS1dE9 double transgenic mice, an AD model, to investigate the effects and mechanisms of curcumin in the prevention and treatment of AD. The water maze test indicated that curcumin can improve spatial learning and memory ability in mice. Immunohistochemical staining and Western blot analysis were used to test major proteins in β-amyloid aggregation, β-amyloid production, and β-amyloid clearance. Data showed that, 3 months after administration, curcumin treatment reduced Aβ40 , Aβ42 , and aggregation of Aβ-derived diffusible ligands in the mouse hippocampal CA1 area; reduced the expression of the γ-secretase component presenilin-2; and increased the expression of β-amyloid-degrading enzymes, including insulin-degrading enzymes and neprilysin. This evidence suggests that curcumin, as a potential AD therapeutic method, can reduce β-amyloid pathological aggregation, possibly through mechanisms that prevent its production by inhibiting presenilin-2 and/or by accelerating its clearance by increasing degrading enzymes such as insulin-degrading enzyme and neprilysin.

Integrity signals

Registry

Crossref · 10.1002/jnr.23322This paper is marked retracted.

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wang, P., Su, C., Li, R., Wang, H., Ren, Y., Sun, H., Yang, J., Sun, J., Shi, J., Tian, J., & Jiang, S.
Affiliations
  • Beijing University of Chinese Medicine (CN)
  • McMaster University (CA)
  • Xinjiang Medical University (CN)
  • Amcare Women and Children's Hospital Beijing China
  • Key Laboratory of Chinese Internal Medicine Ministry of Education, Beijing University of Chinese Medicine (BUCM) China
Corresponding author
Tian, Jinzhou
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2013-11-23
Volume
92
Issue
2
Pages
218-231
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W1486653930
Cited by
65
References
55
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 14 · 2015: 8 · 2014: 2 · 2013: 1
FWCI
5.79
Type
journal article
Language
en
Status
Retracted
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81073076)
  • Beijing Natural Science Foundation (7092057)
  • IRT (0810)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
curcumin, Alzheimer's disease, APP/PS1 mice, spatial learning and memory, amyloid-beta aggregation, amyloid-beta production, presenilin 2, gamma-secretase, insulin-degrading enzyme, neprilysin, amyloid clearance, hippocampus, retraction
MeSH terms
Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Curcumin, Disease Models, Animal, Immunohistochemistry, Memory, Mice, Inbred C57BL, Mice, Transgenic, Blotting, Western, Maze Learning, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review