Cited by 41DNA and Nucleic Acid ChemistryMetal complexes synthesis and propertiesSynthesis and pharmacology of benzodiazepine derivatives

Effects of anticancer drugs on transcription factor–DNA interactions

Gniazdowski, Marek, Denny, William A, Nelson, Stephanie M, Czyz, Malgorzata·2005·Expert Opinion on Therapeutic Targets

Abstract

DNA-interacting anticancer drugs are able to affect the propensity of DNA to interact with proteins through either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These effects can be classified as (i) competition between a drug and regulatory protein for target sequences; (ii) weakening of this interaction; (iii) enhancement of this interaction by chemical modification of the DNA and the creation of non-natural binding sites; and (iv) a 'suicide' mechanism, which is observed when a transcription factor induces changes in DNA structure, allowing a drug to bind to a target sequence. Several new strategies -- the antigene approach with oligonucleotides, peptide nucleic acids or locked nucleic acids, and sequence-specific polyamides -- are also reviewed.

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Crossref · 10.1517/14728222.9.3.471

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125 of 125 references verified0 citation errors · 0 not checkable

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Authors
Gniazdowski, M., Denny, W. A., Nelson, S. M., & Czyz, M.
Affiliations
  • Medical University of Lodz (PL)
  • University of Auckland (NZ)
Venue
Expert Opinion on Therapeutic Targets
Published
2005-06
Volume
9
Issue
3
Pages
471-489
ISSN
  • 1472-8222 (ISSN-L)
  • 1744-7631
OpenAlex
W2129269117
Cited by
41
References
125
Citations by year
2025: 1 · 2023: 1 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Therapeutic Targets (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and pharmacology of benzodiazepine derivatives
Keywords
anticancer agents, transcription factors, protein-DNA interactions, drug-DNA binding, chemical modification of DNA, oligonucleotides, peptide nucleic acid, locked nucleic acid, antisense therapy
MeSH terms
Antineoplastic Agents, DNA, Humans, Neoplasms, Protein Binding, Transcription Factors

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