Effects of anticancer drugs on transcription factor–DNA interactions
Abstract
DNA-interacting anticancer drugs are able to affect the propensity of DNA to interact with proteins through either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These effects can be classified as (i) competition between a drug and regulatory protein for target sequences; (ii) weakening of this interaction; (iii) enhancement of this interaction by chemical modification of the DNA and the creation of non-natural binding sites; and (iv) a 'suicide' mechanism, which is observed when a transcription factor induces changes in DNA structure, allowing a drug to bind to a target sequence. Several new strategies -- the antigene approach with oligonucleotides, peptide nucleic acids or locked nucleic acids, and sequence-specific polyamides -- are also reviewed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In addition to PPI inhibitors, blocking the interaction of TFs with DNA is another option, as some of these factors bind directly to DNA.
“In addition to PPI inhibitors, blocking the interaction of TFs with DNA is another option, as some of these factors bind directly to DNA.465–467”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [467]
Cites
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works
NF-κB in cancer: from innocent bystander to major culprit
Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476 · see citing works
DNA and its associated processes as targets for cancer therapy
Hurley, L. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc749 · Cited by 1,350 · see citing works
The proteasome: a suitable antineoplastic target
Adams, J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1361 · Cited by 1,200 · see citing works
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194 · see citing works
The general transcription factors of RNA polymerase II.Preprint
Orphanides, G. M., Lagrange, T., & Reinberg, D. (1996) · Genes & Development · doi:10.1101/gad.10.21.2657 · Cited by 1,036 · see citing works
LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA
Vester, B., & Wengel, J. (2004) · Biochemistry · doi:10.1021/bi0485732 · Cited by 727 · see citing works
Intercalators as Anticancer Drugs
BRANA, M. F., Cacho, M., Gradillas, A., de Pascual‐Teresa, B., & Ramos, A. (2001) · Current Pharmaceutical Design · doi:10.2174/1381612013397113 · Cited by 445 · see citing works
DNA minor groove binders as potential antitumor and antimicrobial agents
Baraldi, P. G., Bovero, A., Fruttarolo, F., Preti, D., Tabrizi, M. A., Pavani, M. G., & Romagnoli, R. (2004) · Medicinal Research Reviews · doi:10.1002/med.20000 · Cited by 377 · see citing works
Tomasz, M., & Palom, Y. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00088-0 · Cited by 285 · see citing works
The sequence of the human genome. Venter JC, Adams MD, Myers EW, et al. Science 2001;291:1304–1351.
Liesegang, T. J. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01077-7 · Cited by 276 · see citing works
Topoisomerase I Poisons and Suppressors as Anticancer Drugs
Bailly, C. (2000) · Current Medicinal Chemistry · doi:10.2174/0929867003375489 · Cited by 267 · see citing works
Mechanism of action in thalidomide teratogenesis
Stephens, T. D., Bunde, C. J. W., & Fillmore, B. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00388-3 · Cited by 259 · see citing works
Triple helix formation and the antigene strategy for sequence-specific control of gene expression.
Praseuth, D., Guieysse, A., & Héléne, C. (1999) · Biochimica et Biophysica Acta · doi:10.1016/s0167-4781(99)00149-9 · Cited by 242 · see citing works
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
Dickinson, L. A., Gulizia, R. J., Trauger, J. W., Baird, E. E., Mosier, D. E., Gottesfeld, J. M., & Dervan, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12890 · Cited by 219 · see citing works
Targeting the p53–MDM2 interaction to treat cancer
Klein, C., & Vassilev, L. T. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602164 · Cited by 204 · see citing works
Abdelrahim, M., Smith, R., Burghardt, R. C., & Safe, S. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0713 · Cited by 199 · see citing works
Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors
Harrison, R. J., Cuesta, J., Chessari, G., Read, M. A., Basra, S. K., Reszka, A. P., Morrell, J. M., Gowan, S. M., Incles, C. M., Tanious, F. A., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0308693 · Cited by 185 · see citing works
Dyke, M. W. V., & Dervan, P. B. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.16.5555 · Cited by 175 · see citing works
Cisplatin‐ and UV‐damaged DNA lure the basal transcription factor TFIID/TBP
Vichi, P., Coin, F., Renaud, J., Vermeulen, W., Hoeijmakers, J. H. J., Moras, D., & Egly, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7444 · Cited by 172 · see citing works
Grigoriev, M., Praseuth, D., Robin, P., Hémar, A., Saison-Behmoaras, T. E., Dautry‐Varsat, A., Thuong, N. T., Hélène, C., & Harel‐Bellan, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50743-8 · Cited by 167 · see citing works
Dual Topoisomerase I / II Inhibitors in Cancer Therapy
Denny, W. A., & Baguley, B. C. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033452555 · Cited by 153 · see citing works
Self-citationTelomeres and telomerases as drug targets
Rezler, E. M. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00182-0 · Cited by 146 · see citing works
Hurley, L. H., Reck, T., Thurston, D. E., Langley, D. R., Holden, K. G., Hertzberg, R., Hoover, J. R. E., Gallagher, G., & Faucette, L. F. (1988) · Chemical Research in Toxicology · doi:10.1021/tx00005a002 · Cited by 140 · see citing works
Antisense therapeutics: is it as simple as complementary base recognition?
Agrawal, S., & Kandimalla, E. R. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01638-x · Cited by 140 · see citing works
Burd, J. F., Wartell, R. M., Dodgson, J. B., & Wells, R. D. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41284-2 · Cited by 133 · see citing works
EUKARYOTIC TRANSCRIPTION FACTOR-DNA COMPLEXES
Patikoglou, G. A., & Burley, S. K. (1997) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.26.1.289 · Cited by 133 · see citing works
Ho, Y., Wang, Y., & Lin, J. (1996) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199605)16:1 · Cited by 131 · see citing works
Park, Y. G., Nesterova, M., Agrawal, S., & Cho‐Chung, Y. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1573 · Cited by 126 · see citing works
Chatterjee, S., Zaman, K., Ryu, H., Conforto, A. B., & Ratan, R. R. (2001) · Annals of Neurology · doi:10.1002/ana.71.abs · Cited by 126 · see citing works
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates
Belitsky, J. M. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00204-3 · Cited by 112 · see citing works
DNA intercalating anti-tumour agents.
Bc, B. (1991) · PubMed · Cited by 107 · see citing works
Wakelin, L. P. G., Atwell, G. J., Rewcastle, G. W., & Denny, W. A. (1987) · Journal of Medicinal Chemistry · doi:10.1021/jm00388a019 · Cited by 104 · see citing works
Self-citationKopka, M. L., Goodsell, D. S., Han, G. W., Chiu, T. K., Lown, J. W., & Dickerson, R. E. (1997) · Structure · doi:10.1016/s0969-2126(97)00255-4 · Cited by 104 · see citing works
Zlatanova, J. S., Yaneva, J. N., & Leuba, S. H. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.791 · Cited by 99 · see citing works
YARNELL, A., Oh, S., Reinberg, D., & Lippard, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101208200 · Cited by 96 · see citing works
Cell cycle control and cancer chemotherapy
Kohn, K. W., Jackman, J., & O'Connor, P. M. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240540411 · Cited by 96 · see citing works
Energetics of echinomycin binding to DNA
Leng, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg826 · Cited by 96 · see citing works
Welch, J. J., Rauscher, F. J., & Beerman, T. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47389-9 · Cited by 90 · see citing works
Broggini, M., Coley, H. M., Mongelli, N., Pesenti, E. A., Wyatt, M. D., Hartley, J. A., & D’Incalci, M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.1.81 · Cited by 90 · see citing works
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Mischiati, C., & Gambari, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206780200 · Cited by 84 · see citing works
Wei, M., Cohen, S. M., Silverman, A. P., & Lippard, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106374200 · Cited by 79 · see citing works
Zewail‐Foote, M., & Hurley, L. H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja004023p · Cited by 78 · see citing works
Trimmer, E. E., Zamble, D. B., Lippard, S. J., & Essigmann, J. M. (1998) · Biochemistry · doi:10.1021/bi971675q · Cited by 78 · see citing works
Triplex-forming molecules: from concepts to applications
Faria, M., & Giovannangeli, C. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.192 · Cited by 77 · see citing works
Uhlmann, E. J. (1998) · PubMed · Cited by 76 · see citing works
Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA.
Bonfanti, M., Valle, E. L., Faro, J. M. F. S., Faircloth, G. T., Caretti, G., Mantovani, R., & D’Incalci, M. (1999) · PubMed · Cited by 76 · see citing works
Dickinson, L. A., Trauger, J. W., Baird, E. E., Dervan, P. B., Graves, B. J., & Gottesfeld, J. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12765 · Cited by 71 · see citing works
Transcription factors and neoplasia: vistas in novel drug design.
Karamouzis, M. V., Gorgoulis, V. G., & Papavassiliou, A. G. (2002) · PubMed · Cited by 71 · see citing works
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., & Gambari, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33114 · Cited by 67 · see citing works
Palanki, M. S. S. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023371265 · Cited by 66 · see citing works
Chen, X., Ramakrishnan, B., & Sundaralingam, M. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0941 · Cited by 64 · see citing works
Samuel, S. K., Spencer, V. A., Bajno, L., Sun, J.-M., Holth, L. T., Oesterreich, S., & Davie, J. (1998) · PubMed · Cited by 63 · see citing works
Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription
Bellorini, M., Moncollin, V., D’lncalci, M., Mongelli, N., & Mantovani, R. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.10.1657 · Cited by 62 · see citing works
Cutts, S. M., Parsons, P. G., Sturm, R. A., & Phillips, D. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5422 · Cited by 58 · see citing works
FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo
Beckerbauer, L., Tepe, J. J., Cullison, J., Reeves, R., & Williams, R. M. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00028-4 · Cited by 57 · see citing works
Chiang, S.-Y., Azizkhan, J. C., & Beerman, T. A. (1998) · Biochemistry · doi:10.1021/bi9721142 · Cited by 56 · see citing works
Ho, S. N., Boyer, S. H., Schreiber, S. L., Danishefsky, S. J., & Crabtree, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9203 · Cited by 56 · see citing works
Targeting the Ets Binding Site of the HER2/neuPromoter with Pyrrole-Imidazole Polyamides
Chiang, S.-Y., Bürli, R. W., Benz, C. C., Gawron, L. S., Scott, G. K., Dervan, P. B., & Beerman, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000820200 · Cited by 56 · see citing works
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate
Wang, Y. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg215 · Cited by 54 · see citing works
Transcription Factors As Targets for DNA-Interacting Drugs
Gniazdowski, M., Denny, W., Nelson, S., & Czyz, M. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457683 · Cited by 52 · see citing works
Self-citationDNA damage repair and transcription
Bowen, N. J., Palmer, M. B., & Wade, P. A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4177-x · Cited by 52 · see citing works
Anti-repression of RNA Polymerase II Transcription by Pyrrole−Imidazole Polyamides
Dickinson, L. A., Trauger, J. W., Baird, E. E., Ghazal, P., Dervan, P. B., & Gottesfeld, J. M. (1999) · Biochemistry · doi:10.1021/bi9912847 · Cited by 51 · see citing works
Chakrabarti, S., Bhattacharyya, D., & Dasgupta, D. (2000) · Biopolymers · doi:10.1002/1097-0282(2000)56:2 · Cited by 51 · see citing works
Chaires, J. B., Priebe, W., Graves, D. E., & Burke, T. G. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a002 · Cited by 49 · see citing works
Composition and conservation of the telomeric complex
Kanoh, J., & Ishikawa, F. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3245-y · Cited by 49 · see citing works
Inhibition of Ribonucleic Acid-Polymerase Reactions by Actinomycin and Proflavine
GOLDBERG, I. H., Reich, E., & Rabinowitz, M. (1963) · Nature · doi:10.1038/199044a0 · Cited by 49 · see citing works
Aptamers containing thymidine 3′-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB
Yang, X., Fennewald, S. M., Luxon, B. A., Aronson, J. F., Herzog, N. K., & Gorenstein, D. G. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00600-9 · Cited by 46 · see citing works
Analysis of the Effects of Daunorubicin and WP631 on Transcription
Portugal, J., Martin, B., Vaquero, A., Ferrer‐Miralles, N., Villamarı́n, S., & Priebe, W. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373976 · Cited by 44 · see citing works
Taatjes, D. J., Fenick, D. J., & Koch, T. H. (1999) · Chemical Research in Toxicology · doi:10.1021/tx990008q · Cited by 44 · see citing works
Rink, S. M., Yarema, K. J., Solomon, M. S., Paige, L. A., Tadayoni-Rebek, B. M., Essigmann, J. M., & Croy, R. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15063 · Cited by 43 · see citing works
Crinelli, R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh503 · Cited by 41 · see citing works
The Effects of DNA Covalent Adducts on in Vitro Transcription
Gniazdowski, M., & Cera, C. (1996) · Chemical Reviews · doi:10.1021/cr940049l · Cited by 41 · see citing works
Self-citationInhibition of DNA Binding by NF-κB with Pyrrole-Imidazole Polyamides
Wurtz, N. R., Pomerantz, J. L., Baltimore, D., & Dervan, P. B. (2002) · Biochemistry · doi:10.1021/bi020114i · Cited by 40 · see citing works
Peptide Nucleic Acids: On the Road to New Gene Therapeutic Drugs
Nielsen, P. E. (2000) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2000.pto860102.x · Cited by 37 · see citing works
Recognition of Ten Base Pairs of DNA by Head-to-Head Hairpin Dimers
Weyermann, P., & Dervan, P. B. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020258k · Cited by 37 · see citing works
Modulation of transcription factor--DNA interactions by anticancer drugs.
Broggini, M., & D’Incalci, M. (1994) · PubMed · Cited by 37 · see citing works
The Genome as a Drug Target Sequence Specific Minor Groove Binding Ligands
Turner, P., & Denny, W. A. (2000) · Current Drug Targets · doi:10.2174/1389450003349407 · Cited by 36 · see citing works
Self-citationSequence-dependent termination of bacteriophage T7 transcription in vitro by DNA-binding drugs
White, R. J., & Phillips, D. R. (1989) · Biochemistry · doi:10.1021/bi00436a024 · Cited by 36 · see citing works
MacLeod, M. C., Powell, K. L., & Ngoc, T. (1995) · Carcinogenesis · doi:10.1093/carcin/16.5.975 · Cited by 35 · see citing works
p53 binds to cisplatin-damaged DNA
Wetzel, C. C., & Berberich, S. J. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00305-5 · Cited by 34 · see citing works
Search for the Optimal Linker in Tandem Hairpin Polyamides
Kers, I. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00221-3 · Cited by 34 · see citing works
Cisplatin−DNA Binding Specificity of Calf High-Mobility Group 1 Protein
Turchi, J. J., Li, M., & Henkels, K. M. (1996) · Biochemistry · doi:10.1021/bi951843j · Cited by 33 · see citing works
Sequence specificity of formaldehyde-mediated covalent binding of anthracycline derivatives to DNA
Szuławska, A., Gniazdowski, M., & Czyż, M. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.002 · Cited by 32 · see citing works
Self-citationKinetic Studies of the TATA-binding Protein Interaction with Cisplatin-modified DNA
Jung, Y., Mikata, Y., & Lippard, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108299200 · Cited by 32 · see citing works
Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides
Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., & Gottesfeld, J. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1723-1733.2002 · Cited by 32 · see citing works
Marco, E., Garcı́a-Nieto, R., Mendieta, J., Manzanares, I., Cuevas, C., & Gago, F. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010370d · Cited by 31 · see citing works
Taylor, A., Webster, K. A., Gustafson, T. A., & Kedes, L. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006898812618 · Cited by 31 · see citing works
Thalidomide Down-Regulates Transcript Levels of GC-Rich Promoter Genes in Multiple Myeloma
Drucker, L., Uziel, O., Tohami, T., Shapiro, H., Radnay, J., Yarkoni, S., Lahav, M., & Lishner, M. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.415 · Cited by 30 · see citing works
Cooper, J. A. D., Parks, J. M., Carcelen, R., Kahlon, S. S., Sheffield, M., & Culbreth, R. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00375-5 · Cited by 30 · see citing works
Gene targets of antisense therapies in breast cancer
Yang, D. C., Head, J. F., & Elliott, R. L. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.3.375 · Cited by 29 · see citing works
Cell-free and Cellular Activities of a DNA Sequence Selective Hairpin Polyamide-CBI Conjugate
Wang, Y., Dziegielewski, J., Chang, A. Y., Dervan, P. B., & Beerman, T. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207179200 · Cited by 28 · see citing works
Targeting E2F1–DNA complexes with microgonotropen DNA binding agents
Chiang, S.-Y., Bruice, T. C., Azizkhan, J. C., Gawron, L. S., & Beerman, T. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2811 · Cited by 28 · see citing works
Wagner, A. H., Krzesz, R., Gao, D., Schroeder, C., Cattaruzza, M., & Hecker, M. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1333 · Cited by 28 · see citing works
DNA damage repair and transcription
Berardi, P., Russell, M., El‐Osta, A., & Riabowol, K. T. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4179-8 · Cited by 28 · see citing works
Guieysse‐Peugeot, A., Praseuth, D., Giovannangeli, C., Asseline, U., & Hélène, C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3466 · Cited by 27 · see citing works
Sun, D., & Hurley, L. H. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90263-5 · Cited by 26 · see citing works
White, C. M., Heidenreich, O. T., Nordheim, A., & Beerman, T. A. (2000) · Biochemistry · doi:10.1021/bi001427l · Cited by 25 · see citing works
Inhibition of transcription factor-DNA complexes and gene expression by a microgonotropen
White, C. M., Satz, A. L., Bruice, T. C., & Beerman, T. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191374698 · Cited by 25 · see citing works
Zewail‐Foote, M., & Hurley, L. H. (1999) · PubMed · Cited by 25 · see citing works
Sp1-Targeted Inhibition of Gene Transcription by WP631 in Transfected Lymphocytes
Mansilla, S., Priebe, W., & Portugal, J. (2004) · Biochemistry · doi:10.1021/bi036185e · Cited by 24 · see citing works
Targeting of the Sp1 binding sites of HIV-1 long terminal repeat with chromomycin
Bianchi, N., Passadore, M., Rutigliano, C., Feriotto, G., Mischiati, C., & Gambari, R. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00510-2 · Cited by 24 · see citing works
Kašpárková, J. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh896 · Cited by 23 · see citing works
New cancer therapeutics: target-specific in, cytotoxics out?
Broxterman, H. J., & Georgopapadakou, N. H. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.02.004 · Cited by 22 · see citing works
Effects of quinacrine on endothelial cell morphology and transcription factor–DNA interactions
Stuhlmeier, K. M. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00140-9 · Cited by 22 · see citing works
Osteoblastic Differentiation Induced by Transcription Factor Decoy against Estrogen Receptor α Gene
Lambertini, E., Penolazzi, L., Aguiari, G., SENNO, L. D., Pezzetti, F., Sollazzo, V., & Piva, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6708 · Cited by 21 · see citing works
Targeting critical regions in genomic DNA with AT-specific anticancer drugs
WOYNAROWSKI, J. M. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00093-5 · Cited by 21 · see citing works
Transcription factors as drug targets in cancer
Hurst, H. C. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00214-6 · Cited by 21 · see citing works
Combinatorial Determination of Sequence Specificity for Nanomolar DNA-Binding Hairpin Polyamides
Gopal, Y. N. V., & Dyke, M. W. V. (2003) · Biochemistry · doi:10.1021/bi027373s · Cited by 20 · see citing works
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides.
Bremer, R., Wurtz, N. R., Szewczyk, J., & Dervan, P. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00122-5 · Cited by 19 · see citing works
Recent developments in antiangiogenic therapy
Dredge, K. S., Dalgleish, A. G., & Marriott, J. B. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.8.953 · Cited by 17 · see citing works
Transplatin-modified oligonucleotides as modulators of gene expression
Giraud-Panis, M.-J. E., & Leng, M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00058-3 · Cited by 16 · see citing works
Bruice, T. C., Sengupta, D., Blaskó, A., Chiang, S.-Y., & Beerman, T. A. (1997) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(97)00011-4 · Cited by 16 · see citing works
New dsDNA binding unnatural oligopeptides with pyrimidine selectivity
Zhang, Z., Chaltin, P., Aerschot, A. A. V., Lacey, J., Rozenski, J., Busson, R. H., & Herdewijn, P. A. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00268-7 · Cited by 16 · see citing works
Mano, Y., Shimizu, T., Tanuma, S.-I., & Takeda, K. (2000) · PubMed · Cited by 16 · see citing works
bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells
Amstad, P., Liu, H., Ichimiya, M., Chang, S. H., Berezesky, I. K., & Trump, B. F. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199710)20:2 · Cited by 15 · see citing works
Czyż, M., & Gniazdowski, M. (1998) · Acta Biochimica Polonica · doi:10.18388/abp.1998_4319 · Cited by 14 · see citing works
Self-citationSequence selective binding of bis‐daunorubicin WP631 to DNA
Fox, K. R., Webster, R. A. B., Phelps, R. J., Fokt, I., & Priebe, W. (2004) · European Journal of Biochemistry · doi:10.1111/j.0014-2956.2004.04292.x · Cited by 13 · see citing works
Amiodarone for Rapid Cardioversion of Chronic Atrial Tachyarrhythmia?
Nielsen, K. D., & Møller, S. (2000) · Pharmacology & Toxicology · doi:10.1111/j.0901-9928.2000.860607.x · Cited by 12 · see citing works
Transcription factors as targets of anticancer drugs.
Gniazdowski, M., & Czyż, M. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4159 · Cited by 10 · see citing works
Self-citationLee, S., & Hurley, L. H. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991607m · Cited by 9 · see citing works
Sun, D., & Hurley, L. H. (1994) · Gene · doi:10.1016/0378-1119(94)90425-1 · Cited by 8 · see citing works
Anthraquinone-peptides as inhibitors of AP-1 transcription factor
Ijaz, T., Tran, P., Ruparelia, K. C., Teesdale‐Spittle, P. H., Orr, S., & Patterson, L. H. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00653-3 · Cited by 7 · see citing works
Smaill, J. B., Fan, J.-Y., Papa, P., OʼConnor, C. J., & Denny, W. A. (1998) · PubMed · Cited by 6 · see citing works
Self-citationGieseg, M. A., de Bock, C. E., Turner, P. M., Ferguson, L. R., & Denny, W. A. (2002) · Anti-Cancer Drugs · doi:10.1097/00001813-200203000-00009 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Targeting transcription factors in cancer — from undruggable to reality
Bushweller, J. H. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0196-7 · Cited by 919 · see citing works
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Vizcaíno, C., Mansilla, S., & Portugal, J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.008 · Cited by 437 · see citing works
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works
Non-covalent ligand/DNA interactions: Minor groove binding agents
Nelson, S. M., Ferguson, L. R., & Denny, W. A. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.03.012 · Cited by 165 · see citing works
Self-citationUnderstanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice
Vellingiri, B., Iyer, M., Subramaniam, M. D., Jayaramayya, K., Siama, Z., Giridharan, B., Narayanasamy, A., Dayem, A. A., & Cho, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031153 · Cited by 98 · see citing works
Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs
Hayes, F., & Kędzierska, B. (2014) · Toxins · doi:10.3390/toxins6010337 · Cited by 93 · see citing works
Szumilak, M., Szuławska‐Mroczek, A., Koprowska, K., Stasiak, M., Lewgowd, W., Stańczak, A., & Czyż, M. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.09.032 · Cited by 64 · see citing works
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58 · see citing works
Peixoto, P., Liu, Y., Depauw, S., Hildebrand, M., Boykin, D. W., Bailly, C., Wilson, W. D., & David‐Cordonnier, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn208 · Cited by 52 · see citing works
Gong, J., Vaidyanathan, V. G., Yu, X. Y., Kensler, T. W., Peterson, L. A., & Sturla, S. J. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0665951 · Cited by 51 · see citing works
Lenglet, G., & David‐Cordonnier, M. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/290935 · Cited by 50 · see citing works
Sp1 transcription factor as a target for anthracyclines: Effects on gene transcription
Mansilla, S., & Portugal, J. (2008) · Biochimie · doi:10.1016/j.biochi.2007.12.008 · Cited by 42 · see citing works
Metal complexes as inhibitors of transcription factor activity
Leung, C., He, H., Liu, L., Wang, M., Chan, D. S., & Ma, D. (2013) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2013.08.008 · Cited by 40 · see citing works
Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry
Zhaofu, W., Cui, M., Song, F., Lin, L., Liu, Z., & Liu, S. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.04.018 · Cited by 40 · see citing works
Caru, M., Samoilenko, M., Drouin, S., Lemay, V., Kern, L., Romo, L., Bertout, L., Lefebvre, G., Andelfinger, G., Krajinović, M., et al. (2019) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2019.0024 · Cited by 36 · see citing works
Dehkordi, M. F., Darzi, S., Rahmani, B., & Farhadian, S. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114728 · Cited by 35 · see citing works
Wang, Z., Guo, X., Liu, Z., Cui, M., Song, F., & Liu, S. (2007) · Journal of Mass Spectrometry · doi:10.1002/jms.1320 · Cited by 27 · see citing works
Congras, A., Caillet, N., Torossian, N., Quelen, C., Daugrois, C., Brousset, P., Lamant, L., Meggetto, F., & Hoareau‐Aveilla, C. (2018) · Oncotarget · doi:10.18632/oncotarget.24465 · Cited by 27 · see citing works
A diarylamine derived from anthranilic acid inhibits ZIKV replication
Silva, S., Shimizu, J. F., de Oliveira, D. M., de Assis, L. R., Bittar, C., Mottin, M., Sousa, B. K. D. P., Mesquita, N. C. D. M. R., Regasini, L. O., Rahal, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54169-z · Cited by 25 · see citing works
Challenging transcription by DNA-binding antitumor drugs
Portugal, J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.030 · Cited by 25 · see citing works
Portugal, J. (2009) · BMC Pharmacology · doi:10.1186/1471-2210-9-11 · Cited by 22 · see citing works
Study of DNA interactions with cyclic chalcone derivatives by spectroscopic techniques
Štefanišinová, M., Tomečková, V., Kožurková, M., Ostro, A., & Mareková, M. (2011) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2011.06.071 · Cited by 20 · see citing works
Vizcaíno, C., Mansilla, S., Núñez, L. E., Méndez, C., Salas, J. A., Morís, F., & Portugal, J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.003 · Cited by 18 · see citing works
Controlled Sequestration of DNA Intercalated Drug by Polymer–Surfactant Supramolecular Assemblies
Mora, A. K., Singh, P. K., & Nath, S. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b12689 · Cited by 17 · see citing works
Selective inhibition of yeast regulons by daunorubicin: A transcriptome-wide analysis
Rojas, M., Casado, M., Portugal, J., & Piña, B. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-358 · Cited by 14 · see citing works
Selective binding of small molecules to DNA: Application and perspectives
Wang, B., Tan, J., & Zhu, L. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.03.048 · Cited by 13 · see citing works
Caru, M., Petrykey, K., Drouin, S., Beaulieu, P., St-Onge, P., Lemay, V., Bertout, L., Laverdière, C., Andelfinger, G., Krajinović, M., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5651-z · Cited by 13 · see citing works
Peptidosteroid Tweezers Revisited: DNA Binding Through an Optimised Design
Carrette, L. L. G., Morii, T., & Madder, A. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201301854 · Cited by 12 · see citing works
Chromatin as a Target for the DNA-Binding Anticancer Drugs
Majumder, P., Pradhan, S. K., Devi, P. G., Pal, S., & Dasgupta, D. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5466-1_8 · Cited by 11 · see citing works
Lee, Y., Yoo, S., Cho, S., Kim, I., & Kim, I.-S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113885 · Cited by 9 · see citing works
Ma, L., Song, F., Liu, Z., & Liu, S. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6424 · Cited by 9 · see citing works
Kędzierska, B., & Hayes, F. (2016) · doi:10.1002/9781119004813.ch42 · Cited by 9 · see citing works
Caru, M., & Curnier, D. Y. (2020) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2019.0137 · Cited by 7 · see citing works
Peptide scalpels for site-specific dissection of the DNA–protein interface
Verzele, D., Carrette, L. L. G., & Madder, A. (2010) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2010.03.001 · Cited by 7 · see citing works
Insights into DNA‐drug interactions in the era of omics
Portugal, J. (2020) · Biopolymers · doi:10.1002/bip.23385 · Cited by 5 · see citing works
Mansilla, S., Priebe, W., & Portugal, J. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.06.003 · Cited by 3 · see citing works
Evaluation of Flavonoids Binding to DNA Duplexes by Electrospray Ionization
Zhaofu, W., Cui, M., Song, F., Lü, L., Liu, Z., & Liu, S. (2008)
Synthetic Approaches and Challenges to Transcription Factor Inhibitors
Procopiou, G., & Procopiou, P. A. (2018) · Royal Society of Chemistry eBooks · doi:10.1039/9781782624011-00001
- Authors
- Gniazdowski, M., Denny, W. A., Nelson, S. M., & Czyz, M.
- Affiliations
- Medical University of Lodz (PL)
- University of Auckland (NZ)
- ORCID
- Denny, William A
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa UK Limited
- Published
- 2005-06
- Volume
- 9
- Issue
- 3
- Pages
- 471-489
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2129269117
- Cited by
- 41
- References
- 125
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and pharmacology of benzodiazepine derivatives
- Keywords
- anticancer agents, transcription factors, protein-DNA interactions, drug-DNA binding, chemical modification of DNA, oligonucleotides, peptide nucleic acid, locked nucleic acid, antisense therapy
- MeSH terms
- Antineoplastic Agents, DNA, Humans, Neoplasms, Protein Binding, Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review