Drug-induced liver injury: Is it somehow foreseeable?
Open accessAbstract
The classic view on the pathogenesis of drug-induced liver injury is that the so-called parent compounds are made hepatotoxic by metabolism (formation of neo-substances that react abnormally), mainly by cytochromes P-450 (CYP), with further pathways, such as mitochondrial dysfunction and apoptosis, also playing a role. Risk factors for drug-induced liver injury include concomitant hepatic diseases, age and genetic polymorphisms of CYP. However, some susceptibility can today be predicted before drug administration, working on the common substrate, by phenotyping and genotyping studies and by taking in consideration patients' health status. Physicians should always think of this adverse effect in the absence of other clear hepatic disease. Ethical and legal problems towards operators in the health care system are always matters to consider.
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Together the CYP2C and CYP3A families make up 50% of the total CYP population.
“as together the CYP2C and CYP3A families make up 50% of the total CYP population29.”
From Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology (2022) · cites this paper as [29]
Cites
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Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Ewart, L., Apostolou, A., Briggs, S. A., Carman, C. V., Chaff, J. T., Heng, A. R., Jadalannagari, S., Janardhanan, J., Jang, K.-J., Joshipura, S. R., et al. (2022) · Communications Medicine · doi:10.1038/s43856-022-00209-1 · Cited by 337 · see citing works
Cellular Mechanisms of Liver Fibrosis
Acharya, P., Chouhan, K., Weiskirchen, S., & Weiskirchen, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671640 · Cited by 252 · see citing works
- Authors
- Tarantino, G., Minno, M. N. D. D., & Capone, D.
- Affiliations
- Federico II University Hospital (IT)
- Centro Cardiologico Monzino (IT)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2009
- Volume
- 15
- Issue
- 23
- Pages
- 2817
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC2698999
- OpenAlex
- W2056914772
- Cited by
- 137
- References
- 6
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 14 · 2019: 8 · 2018: 3 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 7 · 2012: 7
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- drug-induced liver injury, hepatotoxicity, cytochrome P450, drug metabolism, mitochondrial dysfunction, apoptosis, genetic polymorphism, risk factors, pharmacogenetics, phenotyping, genotyping, adverse drug reactions, legal and ethical issues
- MeSH terms
- Age Factors, Animals, Calcium, Cytochrome P-450 Enzyme System, Disease Susceptibility, Drug Interactions, Genotype, Humans, Hypersensitivity, Immediate, Liver, Liver Diseases, Nutritional Status, Phenotype, Sex Factors, Lipid Peroxidation, Oxidative Stress, Dietary Supplements, Chemical and Drug Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions
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